1,2,3-trimethoxy-4-propenylbenzene | 5273-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,2,3-trimethoxy-4-propenylbenzene
• 英文别名: (E)-4-prop-1'-enyl-1,2,3-trimethoxybenzene；(E)-1,2,3-trimethoxy-4-(prop-1-en-1-yl)benzene；trans-2,3,4-Trimethoxy-1-propenyl-benzol；Benzene, 1,2,3-trimethoxy-4-(1-propenyl)-；1,2,3-trimethoxy-4-[(E)-prop-1-enyl]benzene
• CAS: 5273-90-5
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: BWDCJRUCCWZCIY-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2,3-trimethoxy-4-propenylbenzene 在 四氧化锇 、 N-甲基吗啉氧化物 作用下， 以 水 、 丙酮 、 叔丁醇 为溶剂， 反应 24.0h， 以99%的产率得到rel-(1R,2R)-1-(2',3',4'-trimethoxyphenyl)propane-1,2-diol
  参考文献：
  名称：

  甲氧基在 TiCl4 产物形成中的作用促进 4-苯基二氧戊环异构化

  摘要：

  从 TiCl4 引发的 4-甲氧基苯基和三甲氧基苯基二氧戊环在 -78°C、-30°C 和 0°C 的分子内异构化获得的产物分布提供了对这些基团在此类 Mukaiyama 型重排中发挥的重要区域化学作用的见解，通过它们对二氧戊环的芳环的共振作用.

  DOI：

  10.3998/ark.5550190.0011.206
• 作为产物：
  描述：

  2,3,4-三甲氧基苯甲醛 在 silica gel 、 magnesium 作用下， 以 1,4-二氧六环 、 乙醚 为溶剂， 反应 2.05h， 生成 1,2,3-trimethoxy-4-propenylbenzene
  参考文献：
  名称：

  An Effective System to Synthesize Hypolipidemic Active α-Asarone and Related Methoxylated (E)-Arylalkenes

  摘要：

  通过改进的Grignard反应，分两步制备了甲氧基化（E）-芳基烯烃（1a-1k）。该反应包括在无水乙醚和甲苯中反向加成烷基镁溴化物至苯甲醛（2a-2k），高产率地转化为芳基醇（3a-3k），随后在微波辐射下，根据芳香环上取代基的不同，利用硅胶进行脱水处理3-12分钟，得到具有降脂活性的α-细辛素（1a）及相关甲氧基化（E）-芳基烯烃（1b-1k）。

  DOI：

  10.1246/bcsj.77.2231

文献信息

• Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives
  作者：Jian Zhang、Keman Mu、Peng Yang、Xinqian Feng、Di Zhang、Xiangyu Fan、Qiantao Wang、Shengjun Mao

  DOI：10.1016/j.bioorg.2021.105179

  日期：2021.10

  moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 and 19 exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines.

  在本研究中，我们使用 PTZ 诱导的癫痫模型比较了 α-细辛脑衍生物的抗癫痫作用，以探索其结构-活性关系。我们的研究表明，苯环 3,4,5-位上的供电子甲氧基可增加抗癫痫效力，但其他基团放置在不同位置会降低活性。此外，在烯丙基部分中，烯丙基或1-丁烯基与苯环共轭时可达到最佳活性。化合物5和19对体外（细胞）和体内（小鼠）模型的癫痫表现出更好的神经保护作用。该研究为进一步探索和应用这些化合物作为潜在的抗癫痫药物提供了有价值的数据。
• Neutral Ionic Liquid [hmim]Br as a Green Reagent and Solvent for the Mild and Efficient Dehydration of Benzyl Alcohols into (<i>E</i>)-Arylalkenes Under Microwave Irradiation
  作者：Rakesh Kumar、Abhishek Sharma、Naina Sharma、Vinod Kumar、Arun K. Sinha

  DOI：10.1002/ejoc.200800657

  日期：2008.11

  A mild and efficient, ionic-liquid-assisted, green protocol for the dehydration of benzyl alcohols into the corresponding (E)-arylalkenes under microwave irradiation has been developed. The method utilizes a neutral and recyclable ionic liquid (1-hexyl-3-methylimidazolium bromide) as a reagent and solvent to cleanly provide a wide range of olefins withoutthe need of harsh and expensive Bronsted/Lewis

  已经开发了一种温和高效、离子液体辅助的绿色方案，用于在微波辐射下将苄醇脱水成相应的 (E)-芳基烯烃。该方法利用中性和可回收的离子液体（1-己基-3-甲基咪唑溴化物）作为试剂和溶剂，清洁地提供范围广泛的烯烃，而无需苛刻且昂贵的布朗斯台德/路易斯酸。该方法扩展到将苯甲醇的乙酰化/苯甲酰化衍生物有效转化为其相应的 (E)-芳基烯烃。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
• SYNTHESIS OF THE TRIMETHOXYPHENYLPROPENES
  作者：Alexander T. Shulgin

  DOI：10.1139/v65-478

  日期：1965.12.1

  not available

  不可用。
• Feeding-deterrent activity of ?-asarone isomers against some stored Coleoptera
  作者：Janusz Pop?awski、Bo?ena ?ozowicka、Alina T Dubis、Barbara Lachowska、Zbigiew Winiecki、Jan Nawrot

  DOI：10.1002/(sici)1526-4998(200006)56:6<560::aid-ps171>3.0.co;2-x

  日期：2000.6

  All isomers of alpha-asarone [(E)-4-prop-1-enyl-1,2,5-trimethoxybenze] were tested for their feeding deterrent activity against adults of Sitophilus granarius and Tribolium confusum and larvae of Trogoderma granarium and Tribolium confusum. (E)-2-prop-1-enyl-1,3, 5-trimethoxybenzene exhibited the strongest deterrent activity against all the species tested. The total coefficients of deterrency for this compound were 140.6 and 169.7 for Tribolium confusum adults and larvae, respectively, and 144.9 and 104.6 for larvae of Trogoderma granarium and adults of Sitophilus granarius, respectively. (C) 2000 Society of Chemical Industry.
• Synthesis and Hypolipidemic and Antiplatelet Activities of α-Asarone Isomers in Humans (in Vitro), Mice (in Vivo), and Rats (in Vivo)
  作者：Janusz Popławski、Bożena Łozowicka、Alina T. Dubis、Barbara Lachowska、Stanisław Witkowski、Danuta Siluk、Jacek Petrusewicz、Roman Kaliszan、Jacek Cybulski、Małgorzata Strzałkowska、Zdzisław Chilmonczyk

  DOI：10.1021/jm000905n

  日期：2000.10.1

  yA series of alpha-asarone isomers was synthesized and investigated for their hypolipidemic and antiplatelet activity. Considering the hypolipidemic activity in rats at a dose of 80 mg/kg/day, some isomers were more potent than clofibrate at 150 mg/kg. Compound 3 was one of the most active agents elevating the HDL cholesterol level by 56% and lowering the LDL cholesterol level by 46.8% in rats after 7 days of administration. The activities of the platelet aggregation test in vitro were significant but lower than those of the reference substances (indomethacine and acetylsalicylic add). In the pulmonary thromboembolic in vivo test in mice, two compounds (alpha-asarone (6) and compound 4) produced significant anti thrombotic effects at 100 mg/kg, namely 44% and 52% protection against lung microembolia, respectively. alpha-Asarone derivatives form a new group of potential hypolipidemic and/or antithrombotic agents. The compounds 3, 4, and 6 may serve as lead substances whose structural modifications may result in original drugs.