1-benzyloxy-4-(methylaminomethyl)-3,5-dimethoxybenzene | 879896-36-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyloxy-4-(methylaminomethyl)-3,5-dimethoxybenzene
• 英文别名: 1-(2,6-dimethoxy-4-phenylmethoxyphenyl)-N-methylmethanamine
• CAS: 879896-36-3
• 化学式: C₁₇H₂₁NO₃
• 分子量: 287.359
• InChiKey: PMOBRLGYXRCABP-UHFFFAOYSA-N

物化性质

• 沸点：
  414.4±40.0 °C(Predicted)
• 密度：
  1.089±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.0
• 重原子数：
  21.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  39.72
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-benzyloxy-4-(methylaminomethyl)-3,5-dimethoxybenzene 在 palladium dihydroxide 氢气 作用下， 以 甲醇 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 37.0h， 生成 4-[imidazol-1-ylcarbonyl(methyl)aminomethyl]-3,5-dimethoxyphenol
  参考文献：
  名称：

  Building Addressable Libraries:  Site Selective Coumarin Synthesis and the “Real-Time” Signaling of Antibody−Coumarin Binding

  摘要：

  The feasibility of using active semiconductor chips containing addressable arrays of microelectrodes for the "real-time" monitoring of biologically relevant binding events has been demonstrated by detecting the binding of a coumarin substrate by an anticoumarin antibody. The coumarin substrate was synthesized proximal to predetermined electrodes on the chip with the use of a Pd(II) reagent that was itself generated by using the selected electrodes. Once the coumarin was synthesized, its binding to the anticoumarin antibody was detected by monitoring the current associated with a ferrocene-ferrocinium ion redox cycle that was established between the electrodes on the chip and a remote auxiliary electrode.

  DOI：

  10.1021/ol052891r
• 作为产物：
  描述：

  4-羟基-2,6-二甲氧基苯甲醛 在 sodium cyanoborohydride 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 69.0h， 生成 1-benzyloxy-4-(methylaminomethyl)-3,5-dimethoxybenzene
  参考文献：
  名称：

  Building Addressable Libraries:  Site Selective Coumarin Synthesis and the “Real-Time” Signaling of Antibody−Coumarin Binding

  摘要：

  The feasibility of using active semiconductor chips containing addressable arrays of microelectrodes for the "real-time" monitoring of biologically relevant binding events has been demonstrated by detecting the binding of a coumarin substrate by an anticoumarin antibody. The coumarin substrate was synthesized proximal to predetermined electrodes on the chip with the use of a Pd(II) reagent that was itself generated by using the selected electrodes. Once the coumarin was synthesized, its binding to the anticoumarin antibody was detected by monitoring the current associated with a ferrocene-ferrocinium ion redox cycle that was established between the electrodes on the chip and a remote auxiliary electrode.

  DOI：

  10.1021/ol052891r

文献信息

• Process for performing an isolated Pd(II)-mediated oxidation reaction
  申请人：Moeller D. Kevin

  公开号：US20060205959A1

  公开（公告）日：2006-09-14

  There is disclosed a process for performing an isolated Pd(II) mediated oxidation reaction electrochemically. The inventive process is performed on an electrode array device having a plurality of separately addressable electrodes. Preferably, the Pd(II) mediated oxidation is a Wacker reaction. Specifically, there is disclosed a process for conducting an isolated Pd(II) mediated oxidation on a plurality of electrodes, comprising providing an electrode array device having a plurality of electrodes with a conductive electrode surface and a matrix or coating material over the electrodes surfaces; providing a solution bathing the electrode array matrix or coating material and electrode surfaces, wherein the solution comprises a transition metal species and a confining agent; and biasing one or a plurality of electrodes (“selected electrode or electrodes”) with a voltage or current to regenerate the transition metal species required for the isolated Pd(II) mediated oxidation, whereby the confining agent limits diffusion of the transition metal species to a volume surrounding each selected electrode surface.

  所披露的是一种用电化学方法进行隔离的Pd(II)催化的氧化反应的过程。该发明过程是在具有多个独立寻址电极的电极阵列设备上进行的。优选地，Pd(II)催化的氧化是一种Wacker反应。具体来说，所披露的是一种在多个电极上进行的隔离Pd(II)催化的氧化过程，包括提供一个具有多个电极的电极阵列设备，电极具有导电电极表面和覆盖在电极表面的基质或涂层材料；提供一个溶液来浸泡电极阵列基质或涂层材料和电极表面，其中该溶液包含过渡金属物种和限制剂；以及偏置一个或多个电极（“选定电极或电极”）以电压或电流再生进行隔离Pd(II)催化的氧化所需的过渡金属物种，从而限制剂限制了过渡金属物种向包围每个选定电极表面的体积内的扩散。