D-mannosaminic acid | 16932-62-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-mannosaminic acid
• 英文别名: epichitosamic acid；Epichitosaminsaeure；2-amino-2-deoxy-D-mannonic acid；(2S,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanoic acid
• CAS: 16932-62-0
• 化学式: C₆H₁₃NO₆
• 分子量: 195.172
• InChiKey: UFYKDFXCZBTLOO-KKQCNMDGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  144
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  D-mannosamine 在 sodium hydroxide 、 四氧化锇 作用下， 以 水 为溶剂， 生成 D-mannosaminic acid
  参考文献：
  名称：

  Reactivities of osmium (VIII) towards some aldoses, amino sugars, and methylated sugars in alkaline medium

  摘要：

  DOI：

  10.1002/(sici)1097-4601(1999)31:7<477::aid-kin2>3.0.co;2-4

文献信息

• Kinetic behaviour and relative reactivities of some aldoses, amino sugars, and methylated sugars towards platinum(IV) in alkaline medium
  作者：Kalyan Kali Sen Gupta、Bilkis Ara Begum、Biswajit Pal

  DOI：10.1016/s0008-6215(98)00136-0

  日期：1998.6

  The kinetic behaviour and relative reactivities of some carbohydrates (aldoses, amino sugars and methylated sugars) towards platinum(IV) in alkaline medium have been investigated. The reactions are first order with respect to [substrate] and Pt IV . The rates increase with the increase in OH − . The reactions show pseudo-first-order dependence on OH − . The oxidation rates in alkaline medium follow the

  摘要研究了碱性介质中某些碳水化合物（醛糖，氨基糖和甲基化糖）对铂（IV）的动力学行为和相对反应性。对于[底物]和Pt IV，反应是一阶的。比率随着OH-的增加而增加。反应显示出对OH-的伪一阶依赖性。碱性介质中的氧化速率遵循三糖>四糖>戊糖>己糖的顺序。已经计算出反应的活化参数。已经提出了反应的机制。
• Kinetics and mechanism of the oxidation of some aldoses, amino sugars and methylated sugars by tris(pyridine-2-carboxylato)manganese(III) in weakly acidic medium
  作者：Kalyan Kali Sen Gupta、Bilkis Ara Begum

  DOI：10.1016/s0008-6215(98)00329-2

  日期：1999.1

  Abstract The kinetics of oxidation of some aldoses, amino sugars and methylated sugars by tris(pyridine-2-carboxylato)manganese(III) have been studied spectrophotometrically in sodium picolinate–picolinic acid buffer medium. The reactions are first-order with respect to both manganese(III) and sugar concentrations, but independent with respect to sodium picolinate–picolinic acid buffer medium. The

  摘要在吡啶甲酸钠-吡啶甲酸缓冲液中分光光度法研究了三（吡啶-2-羧甲基）锰（III）对某些醛糖，氨基糖和甲基化糖的氧化动力学。对于锰（III）和糖浓度而言，反应均为一级反应，但对于吡啶甲酸钠-吡啶甲酸缓冲液而言，反应是独立的。讨论了反应机理。
• CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS
  申请人：Leamon Christopher Paul

  公开号：US20100323973A1

  公开（公告）日：2010-12-23

  Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.

  本文描述了一种使用细胞受体结合药物递送共轭物质的组合物和方法，其中包含亲水性空间连接剂，用于成像、诊断和/或治疗由致病细胞群体引起的疾病和疾病状态的靶向药物递送。
• Conjugates containing hydrophilic spacer linkers
  申请人：Endocyte, Inc.

  公开号：US10738086B2

  公开（公告）日：2020-08-11

  Described herein are compositions and methods for use in targeted drug delivery using cell-surface receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations.

  本文描述了使用含有亲水间隔连接体的细胞表面受体结合给药共轭物进行靶向给药的组合物和方法，用于治疗由致病细胞群引起的疾病状态。
• Sen Gupta, Kalyan Kali; Debnath, Nandadulal; Bhattacharjee, Nandini, Journal of the Indian Chemical Society, 2000, vol. 77, # 3, p. 152 - 156
  作者：Sen Gupta, Kalyan Kali、Debnath, Nandadulal、Bhattacharjee, Nandini、Banerjee, Amalendu、Basu, Samarendra Nath

  DOI：——

  日期：——