3-methoxy-2-methyl acryoyl chloride | 52410-41-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯酯类
• 英文名称: 3-methoxy-2-methyl acryoyl chloride
• 英文别名: 3-Methoxy-2-methyl-prop-2-en-saeurechlorid；(Z)-3-methoxy-2-methylprop-2-enoyl chloride
• CAS: 52410-41-0；114274-71-4
• 化学式: C₅H₇ClO₂
• 分子量: 134.562
• InChiKey: JQWNCTPZTFWJLR-ARJAWSKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methoxy-2-methyl acryoyl chloride 以 苯 为溶剂， 反应 4.5h， 生成 N-<(3,3-bisbenzyloxymethylcyclobut-1-yl)-aminocarbonyl>-3-methoxy-2-methyl-2-propenamide
  参考文献：
  名称：

  New cyclobutyl analogs of nucleosides. Part 2. Synthesis and antiviral evaluation of 2-amino-7-[3,3-bis (hydroxymethyl)cyclobut-1-yl]-3H,7H-pyrrolo-[2,3-d]pyrimidin-4-one and of cyclobutyl analogs of the pyrimidine nucleosides

  摘要：

  The synthesis and antiviral evaluation of a series of 3,3-dihydroxymethyl cyclobutane nucleoside analogs related to the natural anti-HIV nucleoside, oxetanocin A are reported. The different purine and pyrimidine nucleoside analogs described in this paper have been obtained from 1-amino-3,3-dibenzyloxymethylcyclobutane. The compounds were tested against HSV-1, HCMV and HIV-1 in cell cultures, but none of them exhibited activity against these viruses. These results suggest the crucial role of the position of both hydroxymethyl groups in oxetanocin A and oxetanocin G for antiviral activity.

  DOI：

  10.1016/0223-5234(91)90196-t

文献信息

• New cyclobutyl analogs of nucleosides. Part 2. Synthesis and antiviral evaluation of 2-amino-7-[3,3-bis (hydroxymethyl)cyclobut-1-yl]-3H,7H-pyrrolo-[2,3-d]pyrimidin-4-one and of cyclobutyl analogs of the pyrimidine nucleosides
  作者：H Boumchita、M Legraverend、A Zerial、M Lemaitre、C Huel、E Bisagni

  DOI：10.1016/0223-5234(91)90196-t

  日期：1991.9

  The synthesis and antiviral evaluation of a series of 3,3-dihydroxymethyl cyclobutane nucleoside analogs related to the natural anti-HIV nucleoside, oxetanocin A are reported. The different purine and pyrimidine nucleoside analogs described in this paper have been obtained from 1-amino-3,3-dibenzyloxymethylcyclobutane. The compounds were tested against HSV-1, HCMV and HIV-1 in cell cultures, but none of them exhibited activity against these viruses. These results suggest the crucial role of the position of both hydroxymethyl groups in oxetanocin A and oxetanocin G for antiviral activity.