2-(3-chlorophenoxy)ethyl chloride | 34272-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(3-chlorophenoxy)ethyl chloride
• 英文别名: (2-chloro-ethyl)-(3-chloro-phenyl)-ether；(2-Chlor-aethyl)-(3-chlor-phenyl)-aether；1-Chloro-3-(2-chloroethoxy)benzene
• CAS: 34272-74-7
• 化学式: C₈H₈Cl₂O
• 分子量: 191.057
• InChiKey: FXAYMUYEENHKFB-UHFFFAOYSA-N

物化性质

• 沸点：
  128-130 °C(Press: 18 Torr)
• 密度：
  1.246±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(3-chlorophenoxy)ethyl chloride 、 2,4,6-三氯苯酚 在 sodium hydroxide 作用下， 生成 1-(3-chloro-phenoxy)-2-(2,4,6-trichloro-phenoxy)-ethane
  参考文献：
  名称：

  Schenbor et al., Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya, 1959, vol. 2, p. 215

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(3-氯苯氧基)乙醇 在 氯化亚砜 作用下， 生成 2-(3-chlorophenoxy)ethyl chloride
  参考文献：
  名称：

  622.一些新的哌替啶类似物。第三部分 1-芳氧基-烷基norpethidines，和类似的类似物

  摘要：

  DOI：

  10.1039/jr9580003065

文献信息

• Quinoline and quinazoline derivatives and drugs containing the same
  申请人：——

  公开号：US20040132727A1

  公开（公告）日：2004-07-08

  There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof: 1 wherein R 1 and R 2 represent hydrogen, alkyl or the like; R 3 , R 4 , R 5 and R 6 represent hydrogen, halogen, alkyl, alkoxy or the like; R 11 and R 12 represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R 3 , R 4 , R 5 and R 6 represent hydrogen and A represents group (v) wherein u is 0 (zero) and R 19 represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.

  提供了一些化合物，可用于治疗由PDGF受体自磷酸化介导的疾病，特别是可抑制新内膜形成肥大的化合物。这些化合物由式（I）或其药理学上可接受的盐或溶剂表示：1其中R1和R2表示氢，烷基或类似物；R3、R4、R5和R6表示氢，卤素，烷基，烷氧基或类似物；R11和R12表示氢，烷基，烷基羰基或类似物；而A表示公式（i）到（x）中的任意一个，但其中R3、R4、R5和R6表示氢，A表示组（v）其中u为0（零）且R19表示苯基，可选地被卤素，烷基或烷氧基取代的化合物被排除。
• QUINOLINE AND QUINAZOLINE DERIVATIVES AND DRUGS CONTAINING THE SAME
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP1243582A1

  公开（公告）日：2002-09-25

  There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof: wherein R1 and R2 represent hydrogen, alkyl or the like; R3, R4, R5, and R6 represent hydrogen, halogen, alkyl, alkoxy or the like; R11 and R12 represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R3, R4, R5 and R6 represent hydrogen and A represents group (v) wherein u is 0 (zero) and R19 represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.

  提供了可用于治疗由 PDGF 受体自身磷酸化介导的疾病的化合物，特别是可抑制新内膜形成肥厚的化合物。这些化合物是式 (I) 所代表的化合物或其药理学上可接受的盐或溶液： 其中 R1 和 R2 代表氢、烷基或类似物；R3、R4、R5 和 R6 代表氢、卤素、烷基、烷氧基或类似物；R11 和 R12 代表氢、烷基、烷基羰基或类似物；A 代表式(i)至(x)中的任意一种，但不包括 R3、R4、R5 和 R6 代表氢且 A 代表基团(v)（其中 u 为 0（零）且 R19 代表任选被卤素、烷基或烷氧基取代的苯基）的化合物。
• Imidazolylchromanones containing non-benzylic oxime ethers: Synthesis and molecular modeling study of new azole antifungals selective against Cryptococcus gattii
  作者：Mojtaba Babazadeh-Qazijahani、Hamid Badali、Hamid Irannejad、Mohammad Hosein Afsarian、Saeed Emami

  DOI：10.1016/j.ejmech.2014.02.019

  日期：2014.4

  A series of imidazolylchromanone oximes containing phenoxyethyl ether moiety, as found in omoconazole, were synthesized and evaluated against yeasts (Candida albicans and Cryptococcus gattii) and filamentous fungi (Aspergillus fumigatus and Exophiala dermatitidis). Although the title compounds showed marginal activity against filamentous fungi but all of them exhibited potent activity against C gattii (MIC values <= 4 mu g/mL). Among them, (3-chlorophenoxy)ethyl analog 7c with MIC value of 0.5 mu g/mL was the most potent compound. Further molecular docking studies provided a better insight into the binding of designed compounds within the homology modeled active site of CnCYP51 (Cryptococcus CYP51-14 alpha-demethylase). (C) 2014 Elsevier Masson SAS. All rights reserved.
• INDAZOLE DERIVATIVES USEFUL AS L-CPT1 INHIBITORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2079703A1

  公开（公告）日：2009-07-22
• US4346244A
  申请人：——

  公开号：US4346244A

  公开（公告）日：1982-08-24