4,5-二甲基-2-氧代-1,3.2-二氧硫杂戊烷 | 4440-90-8

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 中文名称: 4,5-二甲基-2-氧代-1,3.2-二氧硫杂戊烷
• 中文别名: 4,5-二甲基-2-氧代-1,3.2-二氧硫杂环戊烷
• 英文名称: 4,5-dimethyl-1,3,2-dioxathiolane 2-oxide
• 英文别名: 4,5-Dimethyl-1,3,2-dioxathiolan-2-oxid；meso-2,3-Butylen-sulfit
• CAS: 4440-90-8
• 化学式: C₄H₈O₃S
• 分子量: 136.172
• InChiKey: SAPINXZHMGNTEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  54.7
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090
• 危险性防范说明：
  P261,P201,P264,P280,P302+P352+P312,P304+P340+P312
• 危险性描述：
  H302+H312+H332,H341
• 储存条件：
  室温、密封、干燥

SDS

Name:	4 5-Dimethyl-2-Oxo-1 3 2-Dioxathiolane Material Safety Data Sheet
Synonym:	None
CAS:	4440-90-8

Section 1 - Chemical Product MSDS Name:4 5-Dimethyl-2-Oxo-1 3 2-Dioxathiolane Material Safety Data Sheet
Synonym:None

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
4440-90-8	4,5-Dimethyl-2-Oxo-1,3,2-Dioxathiolane	100 %	224-661-1

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin:
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
May cause irritation of the digestive tract. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Combustible liquid. Vapors may be heavier than air.
They can spread along the ground and collect in low or confined areas. Containers may explode when heated.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 4440-90-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 158 deg C @ 760.00mm Hg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 69 deg C ( 156.20 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 1.1770g/cm3
Molecular Formula: C4H8O3S
Molecular Weight: 136.17

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Mechanical shock, incompatible materials, ignition sources, excess heat, temperatures above 65C.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 4440-90-8 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
4,5-Dimethyl-2-Oxo-1,3,2-Dioxathiolane - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 4440-90-8: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 4440-90-8 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 4440-90-8 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4,5-二甲基-2-氧代-1,3.2-二氧硫杂戊烷 在 potassium permanganate 、 硫酸 作用下， 以 二氯甲烷 、 水 为溶剂， 以44%的产率得到4,5-二甲基-1,3,2-二恶噻戊环2,2-二氧化物
  参考文献：
  名称：

  Process for Preparing Optically Active Diphosphanes

  摘要：

  本发明涉及一种从相应取代的外消旋1,2-二醇制备光学活性双膦烷的方法。通过这种方法可以获得的光学活性双膦烷适用作制备手性过渡金属催化剂的配体。

  公开号：

  US20080242893A1
• 作为产物：
  描述：

  2,3-丁二醇 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 4,5-二甲基-2-氧代-1,3.2-二氧硫杂戊烷
  参考文献：
  名称：

  Process for Preparing Optically Active Diphosphanes

  摘要：

  本发明涉及一种从相应取代的外消旋1,2-二醇制备光学活性双膦烷的方法。通过这种方法可以获得的光学活性双膦烷适用作制备手性过渡金属催化剂的配体。

  公开号：

  US20080242893A1

文献信息

• 一种亚硫酸乙烯酯衍生物的合成方法
  申请人：辽宁科隆精细化工股份有限公司

  公开号：CN107987052A

  公开（公告）日：2018-05-04

  本发明涉及一种亚硫酸乙烯酯衍生物的合成方法，属于精细化工合成领域。以钛酸酯为催化剂，用亚硫酸二甲酯和相应的二醇进行酯交换合成目标化合物。催化剂用量为反应物总重量的0.01％～2％。所用二醇与亚硫酸二甲酯的摩尔比为1～1.2。反应温度80‑150℃，并逐渐分馏移除生成的甲醇，待甲醇不再馏出时，停止反应。对反应产物进行真空蒸馏，收集目标物质。该方法具有无腐蚀性，原料转化率高，收率高等优点。
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  作者：Lloyd,E.J.、Porter,Q.N.

  DOI：——

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• A novel preparation of cyclic sulfites through photosulfoxidation of alkenes
  作者：P.W. Jones、A.H. Adelman

  DOI：10.1016/s0040-4020(01)97338-7

  日期：1974.1
• Denivelle, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1939, vol. 208, p. 1025
  作者：Denivelle

  DOI：——

  日期：——
• Wiechert,K. et al., Zeitschrift fur Chemie, 1968, vol. 8, p. 224 - 225
  作者：Wiechert,K. et al.

  DOI：——

  日期：——