1-(methoxymethoxy)-2-vinylbenzene | 189127-43-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(methoxymethoxy)-2-vinylbenzene
• 英文别名: 1-ethenyl-2-(methoxymethoxy)benzene
• CAS: 189127-43-3
• 化学式: C₁₀H₁₂O₂
• 分子量: 164.204
• InChiKey: TVJXQORCQHAAFZ-UHFFFAOYSA-N

物化性质

• 沸点：
  245.7±23.0 °C(Predicted)
• 密度：
  1.012±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(methoxymethoxy)-2-vinylbenzene 在 N-溴代丁二酰亚胺(NBS) 、 triethylamine tris(hydrogen fluoride) 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.5h， 生成 1-(2-Bromo-1-fluoroethyl)-2-(methoxymethoxy)benzene
  参考文献：
  名称：

  3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME

  摘要：

  公开号：

  EP1426365B9
• 作为产物：
  描述：

  2-(methoxymethoxy)benzaldehyde 在 甲基三苯基溴化膦 、 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 以85.2%的产率得到1-(methoxymethoxy)-2-vinylbenzene
  参考文献：
  名称：

  3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME

  摘要：

  公开号：

  EP1426365B9

文献信息

• [EN] KRAS G12D INHIBITORS<br/>[FR] INHIBITEURS DE KRAS G12D
  申请人：MIRATI THERAPEUTICS INC

  公开号：WO2021041671A1

  公开（公告）日：2021-03-04

  The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

  本发明涉及抑制KRas G12D的化合物。具体地，本发明涉及抑制KRas G12D活性的化合物，包括这些化合物的药物组合物以及使用方法。
• Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity
  作者：Sandra Torijano-Gutiérrez、Santiago Díaz-Oltra、Eva Falomir、Juan Murga、Miguel Carda、J. Alberto Marco

  DOI：10.1016/j.bmc.2013.09.064

  日期：2013.12

  compounds were found to have an activity comparable or higher than that of combretastatin A-4 in at least one of the aforementioned biological properties. The compounds with the (E)-arylalkene fragment were in general terms more active than the simple O-alkyl derivatives. However, no clear structure/activity correlations were perceived when comparing the observed compound activities across the three biological

  我们在这里报告了几种在酚羟基烷基化的康维他汀A-4衍生物的合成和生物学评估。这些衍生物中的一些含有（E）-芳基烯烃片段，使人想起某些天然对苯二酚如白藜芦醇中存在的（E）-芳基烯烃片段。确定了对一种人类健康肾脏胚胎细胞和两种肿瘤细胞系的细胞毒性。另外，测量了这些化合物抑制血管内皮生长因子（VEGF）产生的能力。最后，测量了控制端粒酶产生的基因的表达。发现至少在上述生物学特性之一中，某些化合物具有与康普他汀A-4相当或更高的活性。带有（E的化合物）-芳基烯烃片段一般而言比简单的O-烷基衍生物更具活性。但是，比较观察到的三种生物学特性的化合物活性时，没有清晰的结构/活性相关性。这指出了造成细胞毒性的机制之间存在显着差异。
• 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same
  申请人：Tsukamoto Yoshihisa

  公开号：US20050037925A1

  公开（公告）日：2005-02-17

  A compound represented by the formula: [wherein R 1 represents a hydrogen atom, a halogen, atom, alkyl group, etc., R 2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 3 , R 4 , R 5 , R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substituteable cycloalkyl group, etc., or R 3 , R 4 , R 5 , R 6 and R 7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物由以下式子表示：[其中R1代表氢原子，卤素原子，烷基团等，R2代表氢原子，卤素原子，烷基团等，R3，R4，R5，R6和R7各自独立地代表氢原子，卤素原子，可替换的烷基团，可替换的烯基团，炔基团，可替换的环烷基团等，或R3，R4，R5，R6和R7可以形成一个环，该环可以被取代，该环由相邻的两个碳原子形成，这些碳原子与相应的取代基团相连，m和n各自独立地代表0或1。]其盐，酯衍生物及含有该化合物为有效成分的农药，以及含有该化合物和第二种草甘膦活性化合物为有效成分的除草剂组合物。
• 3-Phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same
  申请人：Tsukamoto Yoshihisa

  公开号：US20100041555A1

  公开（公告）日：2010-02-18

  A compound represented by the formula: [wherein R 1 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 3 , R 4 , R 5 , R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitutable cycloalkyl group, etc., or R 3 , R 4 , R 5 , R 6 and R 7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物，其化学式为：[其中R1代表氢原子、卤素原子、烷基等，R2代表氢原子、卤素原子、烷基等，R3、R4、R5、R6和R7各自独立地代表氢原子、卤素原子、可替换的烷基、可替换的烯基、炔基、可替换的环烷基等，或R3、R4、R5、R6和R7可形成一个环，该环可以被取代，由它们中的相邻两个碳原子形成，各自带有相应的取代基，m和n各自独立地代表0或1。]其盐、酯衍生物和含有该化合物作为有效成分的农药，以及含有该化合物和第二种除草活性化合物作为有效成分的除草剂组合物。
• 3-phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same
  申请人：Mitsui Chemicals Agro, Inc.

  公开号：US07964531B2

  公开（公告）日：2011-06-21

  A compound represented by the formula: [wherein R1 represents a hydrogen atom, a halogen atom, alkyl group, etc., R2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R3, R4, R5, R6 and R7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitutable cycloalkyl group, etc., or R3, R4, R5, R6 and R7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物，其化学式为：[其中R1代表氢原子、卤素原子、烷基等，R2代表氢原子、卤素原子、烷基等，R3、R4、R5、R6和R7各自独立地代表氢原子、卤素原子、可替换的烷基、可替换的烯基、炔基、可替换的环烷基等，或R3、R4、R5、R6和R7可以形成一个环，该环可以被取代，由它们中相邻的两个碳原子形成，各自带有相应的取代基，m和n各自独立地代表0或1]，其盐、酯衍生物及含有其作为有效成分的农药，以及含有该化合物和第二种除草活性化合物作为有效成分的除草剂组合物。