5-羟基-2-茚酮 | 52727-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: 5-羟基-2-茚酮
• 中文别名: 5-羟基茚满-2-酮
• 英文名称: 5-hydroxy-1H-inden-2(3H)-one
• 英文别名: 5-Hydroxy-indan-2-on；5-Hydroxyindan-2-on；5-Hydroxy-indan-2-one；5-hydroxy-1,3-dihydroinden-2-one
• CAS: 52727-23-8
• 化学式: C₉H₈O₂
• mdl: MFCD08437309
• 分子量: 148.161
• InChiKey: ROYXQDPCGSWTLM-UHFFFAOYSA-N

物化性质

• 熔点：
  188-191 °C
• 沸点：
  338.6±42.0 °C(Predicted)
• 密度：
  1.305±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2914400090

反应信息

• 作为产物：
  描述：

  对羟基苯乙酸 在 dirhodium tetracetate dihydrate 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 5-羟基-2-茚酮
  参考文献：
  名称：

  Synthesis of (±)-Brazilin Using IBX

  摘要：

  [GRAPHICS]A short synthesis of (+/-)-brazilin is reported. This synthesis uses several interesting and underutilized transformations including a regioselective dirhodium-catalyzed aryl C-H insertion, a regioselective IBX phenol -> o-quinone oxidation, a tautomerization of an o-quinone to a p-quinone methide, and an intramolecular aryl cyclization with a p-quinone methide.

  DOI：

  10.1021/ol0523749

文献信息

• INDENYL DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Wilson David Matthew

  公开号：US20090306052A1

  公开（公告）日：2009-12-10

  The present invention relates to novel indenyl derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

  本发明涉及具有药理活性的新型茚基衍生物，其制备过程，含有它们的组合物以及它们在治疗神经系统和精神疾病中的应用。
• Hydroxylation du benzaldehyde et de cetones aromatiques par le peroxyde d'hydrogene en milieu superacide
  作者：Jean-Pierre Gesson、Jean-Claude Jacquesy、Marie-Paule Jouannetaud、Guy Morellet

  DOI：10.1016/s0040-4039(00)88104-6

  日期：1983.1
• GESSON, J. -P.;JACQUESY, J. -C.;JOUANNETAUD, M. -P.;MORELLET, G., TETRAHEDRON LETT., 1983, 24, N 30, 3095-3098
  作者：GESSON, J. -P.、JACQUESY, J. -C.、JOUANNETAUD, M. -P.、MORELLET, G.

  DOI：——

  日期：——
• AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
  申请人：Abbott GmbH & Co. KG

  公开号：EP2603481B1

  公开（公告）日：2014-09-17
• DYE COMPOSITION USING A 2-HYDROXYNAPHTHALENE, (ACYLAMINO)PHENOL OR QUINOLINE COUPLER IN A FATTY-SUBSTANCE-RICH MEDIUM, DYEING PROCESS AND DEVICE THEREFOR
  申请人：Lagrange Alain

  公开号：US20140041133A1

  公开（公告）日：2014-02-13

  The present invention relates to a cosmetic composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising: a) one or more fatty substances; b) one or more surfactants; c) one or more oxidation bases; d) one or more couplers based on 2-hydroxynaphthalene derivatives or particular phenol derivatives, acylaminophenol derivatives or quinoline derivatives; f) one or more basifying agents; e) optionally one or more chemical oxidizing agents; and the fatty substance content representing in total at least 25% by weight relative to the total weight of the formulation. The present invention also relates to a process using this composition, and to a multi-compartment device that is suitable for performing the said process.