4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide | 1124321-37-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide
• 英文别名: 4-[(3-Bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulfonamide；4-[[(3-bromo-2-methylimidazo[1,2-a]pyrazin-8-yl)amino]methyl]benzenesulfonamide
• CAS: 1124321-37-4
• 化学式: C₁₄H₁₄BrN₅O₂S
• 分子量: 396.267
• InChiKey: JPHRGNAQHVVFIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide 、 4-羟基苯硼酸频哪醇酯 在 palladium diacetate 、 双(2-二苯基磷苯基)醚 sodium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 以10%的产率得到4-[[[3-(4-hydroxyphenyl)-2-methyl-imidazo[1,2-a]pyrazin-8-yl]amino]methyl]benzenesulfonamide
  参考文献：
  名称：

  [EN] IMIDAZO [1,2-A] PYRAZINE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS SUCH AS HEPATITIS
  [FR] COMPOSÉS D'IMIDAZOPYRAZINE

  摘要：

  公开号：

  WO2009024585A3
• 作为产物：
  描述：

  8-氯-2-甲基咪唑并[1,2-a]吡嗪 在 N-溴代丁二酰亚胺(NBS) 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 异丁醇 为溶剂， 反应 18.5h， 生成 4-[(3-bromo-2-methyl-imidazo[1,2-a]pyrazin-8-ylamino)-methyl]-benzenesulphonamide
  参考文献：
  名称：

  Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections

  摘要：

  Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIII beta. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.

  DOI：

  10.1021/ml400095m

文献信息

• IMIDAZOPYRAZINE COMPOUNDS
  申请人：Macleod Angus

  公开号：US20110166147A1

  公开（公告）日：2011-07-07

  Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

  本发明揭示了一种具有以下公式（I）所表示的化学式的新型咪唑吡唑化合物。该化合物可制备成药物组合物，并可用于预防和治疗病人中的病毒感染，特别是HCV、HRV、Sb和/或CVB。
• Substituted imidazo[1,2-a]pyrazine compounds useful for the treatment of viral infections
  申请人：MacLeod Angus

  公开号：US08362018B2

  公开（公告）日：2013-01-29

  Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

  本发明涉及新型咪唑吡嗪化合物，其化学式如下：所述化合物可制备为药物组合物，并可用于预防和治疗病毒感染，特别是治疗HCV、HRV、Sb和/或CVB等病毒感染的患者。
• Imidazo[1,2-a]pyrazine compounds for treatment of viral infections such as hepatitis
  申请人：Biofocus DPI Limited

  公开号：EP2567960A2

  公开（公告）日：2013-03-13

  Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

  本发明公开了新型咪唑吡嗪化合物，其分子式如下： 这些化合物可制备成药物组合物，并可用于预防和治疗病毒感染，特别是有需要的患者的 HCV、HRV、Sb 和/或 CVB。
• IMIDAZO[1,2-A]PYRAZINE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS SUCH AS HEPATITIS
  申请人：Biofocus DPI Limited

  公开号：EP2193131A2

  公开（公告）日：2010-06-09
• US8362018B2
  申请人：——

  公开号：US8362018B2

  公开（公告）日：2013-01-29