2,5-Anhydro-1-azido-1,4-dideoxy-3-thio-D-threo-pentitol | 161855-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2,5-Anhydro-1-azido-1,4-dideoxy-3-thio-D-threo-pentitol
• 英文别名: (2R,3R)-2-(azidomethyl)oxolane-3-thiol
• CAS: 161855-48-7
• 化学式: C₅H₉N₃OS
• 分子量: 159.212
• InChiKey: QDBBNZHQWWXKFN-RFZPGFLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,5-Anhydro-1-azido-1,4-dideoxy-3-thio-D-threo-pentitol 在 palladium on activated charcoal 氢气 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成 CL 191121
  参考文献：
  名称：

  Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems

  摘要：

  A series of twelve highly active aminomethyl-THF 1 beta-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only moderate anti-pseudomonal activity. Most importantly, they demonstrated moderate intrinsic oral activity against an E. coli infection in mice. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00282-5
• 作为产物：
  描述：

  1,2-二脱氧-D-核糖 在 吡啶 、 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 生成 2,5-Anhydro-1-azido-1,4-dideoxy-3-thio-D-threo-pentitol
  参考文献：
  名称：

  Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems

  摘要：

  A series of twelve highly active aminomethyl-THF 1 beta-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only moderate anti-pseudomonal activity. Most importantly, they demonstrated moderate intrinsic oral activity against an E. coli infection in mice. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00282-5