3,4-二氢-6-甲基-3-氧代-2-吡嗪羧酰胺 | 88394-06-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3,4-二氢-6-甲基-3-氧代-2-吡嗪羧酰胺
• 中文别名: 6-甲基-3-氧代-3,4-二氢吡嗪-2-甲酰胺
• 英文名称: 2-Hydroxy-5-methyl-pyrazin-3-carbonsaeure-amid
• 英文别名: 6-methyl-3-oxo-3,4-dihydro-pyrazine-2-carboxylic acid amide；3-hydroxy-6-methyl-pyrazine-2-carboxylic acid amide；6-Methyl-3-oxo-3,4-dihydropyrazine-2-carboxamide；5-methyl-2-oxo-1H-pyrazine-3-carboxamide
• CAS: 88394-06-3
• 化学式: C₆H₇N₃O₂
• 分子量: 153.14
• InChiKey: WUPAWCXFTGKASP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  84.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-二氢-6-甲基-3-氧代-2-吡嗪羧酰胺 在 氢氧化钾 、 溴 作用下， 以 水 为溶剂， 反应 1.5h， 以76%的产率得到2-氨基-3-羟基-6-甲基吡嗪
  参考文献：
  名称：

  [EN] IMIDAZO [1,2-A] PYRAZINE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS SUCH AS HEPATITIS
  [FR] COMPOSÉS D'IMIDAZOPYRAZINE

  摘要：

  公开号：

  WO2009024585A3
• 作为产物：
  描述：

  2-氨基丙二酰胺 、 丙酮醛 在 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 反应 48.0h， 以28%的产率得到3,4-二氢-6-甲基-3-氧代-2-吡嗪羧酰胺
  参考文献：
  名称：

  [EN] IMIDAZO [1,2-A] PYRAZINE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS SUCH AS HEPATITIS
  [FR] COMPOSÉS D'IMIDAZOPYRAZINE

  摘要：

  公开号：

  WO2009024585A3

文献信息

• PYRAZINO[2,3-D]ISOXAZOLE DERIVATIVE
  申请人：FUJIFILM CORPORATION

  公开号：US20130245264A1

  公开（公告）日：2013-09-19

  The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): wherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents —C(═O)R or —CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.

  本发明的目的是提供一种化合物，该化合物可用作吡嗪羧酰胺衍生物的生产中间体，例如6-氟-3-羟基-2-吡嗪羧酰胺。本发明提供了一种由下式（I）表示的吡嗪并[2,3-d]异噁唑衍生物： 其中X代表卤素原子、羟基或磺胺氧基，Y代表—C(═O)R或—CN；其中R代表氢原子、烷氧基、芳氧基、烷基、芳基或氨基。
• Novel virus proliferaton inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue
  申请人：——

  公开号：US20040235761A1

  公开（公告）日：2004-11-25

  1 wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and A has the same meaning as given in the specification. The present invention relates to a method for exhibiting a virus growth-inhibiting effect and/or a virucidal effect, in which pyrazine nucleotide analog [2] and pyrazine nucleoside analog [3z] are subjected to biotransformation, decomposed and then phosphorylated, so that they become a pyrazine nucleotide analog [1b] exhibiting the aforementioned effect. This method is useful as a method for treating virus infections. Moreover, the pyrazine carboxamide analog or a salt thereof of the present invention is useful as an agent for preventing or treating virus infections.

  本发明涉及一种展示病毒生长抑制效应和/或病毒灭活效应的方法，其中将吡嗪核苷酸类似物[2]和吡嗪核苷类似物[3z]经生物转化、分解和磷酸化，使其成为展示前述效应的吡嗪核苷酸类似物[1b]。该方法可用作治疗病毒感染的方法。此外，本发明的吡嗪羧酰胺类似物或其盐可用作预防或治疗病毒感染的药剂。其中R1、R2、R3、R4、R5、R6、R7、R8、R9和A的含义与规范中所述相同。
• IMIDAZOPYRAZINE COMPOUNDS
  申请人：Macleod Angus

  公开号：US20110166147A1

  公开（公告）日：2011-07-07

  Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

  本发明揭示了一种具有以下公式（I）所表示的化学式的新型咪唑吡唑化合物。该化合物可制备成药物组合物，并可用于预防和治疗病人中的病毒感染，特别是HCV、HRV、Sb和/或CVB。
• Substituted imidazo[1,2-a]pyrazine compounds useful for the treatment of viral infections
  申请人：MacLeod Angus

  公开号：US08362018B2

  公开（公告）日：2013-01-29

  Novel imidazopyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a viral infection, in particular a HCV, HRV, Sb and/or CVB in a patient in need thereof.

  本发明涉及新型咪唑吡嗪化合物，其化学式如下：所述化合物可制备为药物组合物，并可用于预防和治疗病毒感染，特别是治疗HCV、HRV、Sb和/或CVB等病毒感染的患者。
• SUBSTITUTED PYRAZINO[2,3-D]ISOOXAZOLES AS INTERMEDIATES FOR THE SYNTHESIS OF SUBSTITUTED PYRAZINECARBOXAMIDES
  申请人：FUJIFILM Corporation

  公开号：US20150051396A1

  公开（公告）日：2015-02-19

  The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): wherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents —C(═O)R or —CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.

  本发明的目的在于提供一种化合物，该化合物可用作吡嗪羧酰胺衍生物的生产中间体，例如6-氟-3-羟基-2-吡嗪羧酰胺。本发明提供了一种由式（I）表示的吡嗪并[2,3-d]异噁唑衍生物：其中X代表卤素原子、羟基或磺酰氧基，Y代表—C(═O)R或—CN；其中R代表氢原子、烷氧基、芳氧基、烷基、芳基或氨基。