阿老哥儿1260 | 38380-07-3

• 物质功能分类: 分析化学 - 标准品 - 挥发性有机化合物(VOCs)
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 阿老哥儿1260
• 中文别名: 亚老哥尔1260；多氯联苯-1260；亚老哥儿1260；1,1'-联苯氯代衍生物1260；多氯联苯1260标准品；亚老哥儿 1260；六氯联苯；亚老哥儿 126；2,2',3,3',4,4'-六氯联苯
• 英文名称: 2,2',3,3',4,4'-hexachlorobiphenyl
• 英文别名: 2,2′,3,3′,4,4′-hexachlorobiphenyl；2,2',3,3',6,6'-hexachlorobiphenyl；2,3,4,2',3',4'-Hexachlorobiphenyl；2,2',3,3'4,4'-hexachlorobiphenyl；2,2'3,3',4,4'-hexachlorobiphenyl；1,2,3-trichloro-4-(2,3,4-trichlorophenyl)benzene
• CAS: 38380-07-3；11096-82-5
• 化学式: C₁₂H₄Cl₆
• 分子量: 360.882
• InChiKey: BTAGRXWGMYTPBY-UHFFFAOYSA-N

物化性质

• 熔点：
  115.76°C (estimate)
• 沸点：
  457.69°C (rough estimate)
• 密度：
  1.5800 (estimate)
• 闪点：
  11 °C
• 溶解度：
  可溶于大多数溶剂(USEPA,1985)
• 物理描述：
  Pcb-1260 is a viscous oily liquid. (NTP, 1992)
• 颜色/状态：
  Light yellow, soft, sticky resin
• 蒸汽压力：
  4.05X10-5 mm Hg at 25 °C
• 亨利常数：
  1.30e-05 atm-m3/mole
• 稳定性/保质期：
  ... PCB's are chemically very inert and are stable to conditions of hydrolysis and oxidation in industrial use. ... /Polychlorinated biphenyls/
• 分解：
  When heated to decomposition they emit highly toxic fumes of chlorine. /Polychlorinated biphenyls/
• 粘度：
  At 54.4 °C: 3200-4500 Saybolt sec; at 98.9 °C: 72-78 Saybolt sec
• 折光率：
  Index of refraction at 20 °C = 1.647-1.649
• 相对蒸发率：
  Evaporation loss at 100 °C for 6 hours is 0-0.1%.
• 保留指数：
  2322

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

代谢

多氯联苯（PCBs）通过吸入、口服和皮肤接触途径被吸收。它们通过血液传输，通常与白蛋白结合。由于其亲脂性，它们倾向于在富含脂质的组织中积累，如肝脏、脂肪组织和皮肤。多氯联苯的代谢非常缓慢，并且根据氯化的程度和位置而有所不同。多氯联苯通过微粒体单加氧酶系统进行代谢，该系统由细胞色素P-450酶催化，转化为极性代谢物，这些代谢物可以与谷胱甘肽和葡萄糖醛酸结合。主要代谢物是羟基化产物，通过胆汁和粪便排出。多氯联苯的缓慢代谢意味着它们倾向于在身体组织中积累。

PCBs are absorbed via inhalation, oral, and dermal routes of exposure. They are trasported in the blood, often bound to albumin. Due to their lipophilic nature they tend to accumulate in lipid-rich tissues, such as the liver, adipose, and skin. Metabolism of PCBs is very slow and varies based on the degree and position of chlorination. PCBs are metabolized by the microsomal monooxygenase system catalyzed by cytochrome P-450 enzymes to polar metabolites that can undergo conjugation with glutathione and glucuronic acid. The major metabolites are hydroxylated products which are excreted in the bile and faeces. The slow metabolism of PCBs means they tend to accumulate in body tissues. (L4, T6)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

PCB的作用机制因具体类型而异。类二噁烷PCB通过结合芳基烃受体，通过改变基因的转录来扰乱细胞功能，主要是通过诱导肝脏第一阶段和第二阶段酶的表达，特别是细胞色素P450家族。PCB的大多数毒性效应被认为是由Ah受体结合的结果。其他PCB被认为会干扰钙通道和/或改变大脑中的多巴胺水平。PCB还通过改变甲状腺激素的生成和结合到雌激素受体来引起内分泌紊乱，这可以刺激某些癌细胞的生长并产生其他雌激素效应，如生殖功能障碍。它们会通过结合到如uteroglobin等受体蛋白而生物累积。(A3, A4, A30, A66)

The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

1, 对人类致癌。

1, carcinogenic to humans. (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

PCBs最常见的健康影响是皮肤状况，如氯痤疮和皮疹。长期暴露于PCBs还可能导致肝脏、胃和肾脏损害、黄疸、水肿、贫血、免疫系统变化、行为改变以及生殖能力受损。

The most common health effects of PCBs are skin conditions such as chloracne and rashes. Chronic PCB exposure has also been shown to cause liver, stomach and kidney, damage, jaundice, edema, anemia, changes in the immune system, behavioral alterations, and impaired reproduction. (L4)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

口服（L4级）；吸入（L4级）；皮肤给药（L4级）

Oral (L4) ; inhalation (L4) ; dermal (L4)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

慢性 PCB 暴露会导致如下症状：腹痛、恶心、呕吐、腹泻、头痛、眩晕、抑郁、神经紧张、皮肤和眼睛损伤、疲劳、月经周期不规律以及免疫力下降。

Chronic PCB exposure results in symptoms such as abdominal pain, nausea, vomiting, diarrhea, headache, dizziness, depression, nervousness, dermal and ocular lesions, fatigue, irregular menstrual cycles and a lowered immune response. (A3)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• 危险等级：
  9
• 危险品标志：
  N
• 安全说明：
  S60,S61
• 危险类别码：
  R33,R50/53

反应信息

• 作为反应物：
  描述：

  阿老哥儿1260 生成 2,2',4,4'-四氯联苯
  参考文献：
  名称：

  Oefjord Gro D., Puhakka Jaakko A., Ferguson John F., Environ. Sci. and Technol., 28 (1994) N 13, S 2286-2294

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3,4-三氯碘苯 在 铜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 阿老哥儿1260
  参考文献：
  名称：

  Physical, spectral and chromatographic properties of all 209 individual PCB congeners

  摘要：

  Physical, spectral and chromatographic data for all 209 individual PCB congeners is presented. The individual congeners were synthesized and then isolated and purified. Recent emphasis on the source of the toxicity of commercial PCB formulations has increased the need for a complete set of the PCB congeners. Through the use of two capillary GC columns: 40% octadecyl/ 15% phenyl methyl siloxane and 50% phenyl methyl siloxane, it was possible to separate 201 PCB congeners with only four unresolved pairs. The data compiled in this study for all 209 congeners will aid in the identification of selected individual components of these environmental pollutants. The use of this data also presents the opportunity for the improved quantification of the commercial PCB formulations.

  DOI：

  10.1016/0045-6535(95)00140-4

文献信息

• Mechanism of PCBs formation from the pyrolysis of chlorobenzenes
  作者：Peng-Yan Liu、Ming-Hui Zheng、Bing Zhang、Xiao-Bai Xu

  DOI：10.1016/s0045-6535(00)00434-3

  日期：2001.5

  Polychlorinated biphenyls (PCBs) were formed by pyrolysis of chlorobenzenes in a HCl atmosphere. Varieties of substituted chlorobenzenes were used as model compounds to optimize the condensation reaction. Lower chlorinated benzenes produce more PCBs than that of higher ones. Up to 0.7 microg PCBs/mg 1,2,3-trichlorobenzene was produced through the condensation reaction.

  多氯联苯（PCB）是通过在HCl气氛中热解氯苯而形成的。各种取代的氯苯用作模型化合物以优化缩合反应。与较高的氯苯相比，较低的氯苯可生产更多的PCB。通过缩合反应可生产至多0.7 microg PCBs / mg 1,2,3-三氯苯。
• Zinc borate, and production method and use thereof
  申请人：——

  公开号：US20030030042A1

  公开（公告）日：2003-02-13

  A zinc borate having a particular crystallite size and containing very little sodium components and a method of preparing the same. The zinc borate has a particular chemical composition, has a crystallite size of not smaller than 40 nm as found from diffraction peaks of indexes of planes of (020), (101) and (200) in the X-ray diffraction image (Cu-k&agr;) and contains sodium components in amounts of not larger than 100 ppm as measured by the atomic absorptiometric method.

  一种具有特定晶粒尺寸且含有极少钠成分的锌硼酸盐及其制备方法。该锌硼酸盐具有特定的化学组成，其晶粒尺寸不小于40纳米，可以从X射线衍射图像（Cu-kα）的（020）、（101）和（200）平面的衍射峰中发现，并且钠成分的含量不超过100 ppm，由原子吸收光谱法测量。
• Instruments for detecting low-molecular weight substance
  申请人：Mizukami Haruki

  公开号：US20050148097A1

  公开（公告）日：2005-07-07

  To provide the following instruments 1 and 2 as a low-molecular-weight substance detection instrument employing immunochromatography capable of detecting conveniently and sensitively detecting a low-molecular weight substance such as an environmental pollutant (e.g., a dioxin), as a target substance contained in a test sample: 1. an instrument, which comprises 1) a test sample application section with which a test sample is brought into contact; 2) a label product reaction section containing a label product containing, as a portion thereof, an antibody capable of binding to a target substance contained in the test sample, the label product being not bound to the reaction section; 3) an unbound label product capturing section containing an element capable of capturing the label product which is not bound to the target substance, the element being bound to the capturing section; and 4) a detection section containing a detection element which, when coming into contact with the target substance bound to the label product, causes a visually observable change, and 2. an instrument wherein a test sample is reacted with a labeled antibody containing, as a portion thereof, an antibody capable of binding to a target substance contained in the test sample, and the resultant reaction product is employed for detecting the target substance contained in the test sample.

  提供以下仪器1和2作为低分子量物质检测仪器，采用免疫层析技术，能够方便敏感地检测低分子量物质，例如环境污染物（例如二恶英），作为测试样品中包含的目标物质：1. 仪器，包括1）测试样品应用部分，用于将测试样品接触；2）标签产物反应部分，包含一种标签产物，其中包含一种能够结合到测试样品中的目标物质的抗体，标签产物未结合到反应部分；3）未结合标签产物捕获部分，包含一种能够捕获未结合到目标物质的标签产物的元素，该元素与捕获部分结合；以及4）检测部分，包含一种检测元素，当与结合到标签产物的目标物质接触时，会引起可视的变化；2. 仪器，其中测试样品与标记抗体反应，其中一部分包含能够结合到测试样品中的目标物质的抗体，产生的反应产物用于检测测试样品中包含的目标物质。
• Glasfaserverstärkte Polyesterformmassen und deren Verwendung
  申请人：CIBA-GEIGY AG

  公开号：EP0022752A1

  公开（公告）日：1981-01-21

  Die glasfaserverstärkten Polyesterformmassen enthalten einen Polyester, der zu mindestens 90 Mol-% ein Polyester aus Butandiol-(1,4) und trans-Cyclohexandicarbonsäure-(1,4) oder polyesterbildenden Derivaten davon ist. Der Gehalt an Glasfasern beträgt vorzugsweise 2 bis 60 Gew.-%, bezogen auf die Formmasse. Die Formmassen zeichnen sich aus durch eine verbesserte Kriechstromfestigkeit.

  玻璃纤维增强聚酯模塑料含有至少 90 摩尔%的丁二醇-(1,4)和反式-环己烷二甲酸-(1,4)聚酯或其聚酯形成衍生物。 玻璃纤维含量最好占模塑料重量的 2% 至 60%。 模塑料的特点是抗跟踪性更好。
• Process for dehalogenation of organic halides
  申请人：ONTARIO HYDRO

  公开号：EP0099951A1

  公开（公告）日：1984-02-08

  Halogenated species such as PCB dissolved in hydrocarbon-based oils such as electrical insulating oils, turbine oils and crankcase oils are dehalogenated by contacting the oil with a fine dispersion of molten sodium particles of which at least 80% are below 10 microns particle size, at a temperature of 100 to 160 °C. The process removes hazardous halogenated species and, after separation of excess sodium suspended solids and, if necessary, water washing, drying, and activated clay treatment, may permit the oil to be re-used.

  将溶解在烃基油（如电绝缘油、涡轮机油和曲轴箱油）中的多氯联苯等卤化物与熔融钠颗粒的细小分散体（其中至少有 80% 的颗粒尺寸小于 10 微米）在 100 至 160 °C 的温度下接触，可对其进行脱卤处理。该工艺可去除有害的卤化物质，在分离多余的钠悬浮固体并在必要时进行水洗、烘干和活性白土处理后，可允许油品重新使用。

表征谱图