氯普噻唑 | 6469-36-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 氯普噻唑
• 中文别名: 甲氯丙噻唑；氯丙甲噻唑
• 英文名称: 5-(3-chloropropyl)-4-methylthiazole
• 英文别名: 5-(γ-Chloropropyl)-4-methylthiazole；cloprothiazole；5-<3-Chlor-phenyl>-4-methyl-thiazol；5-(3-chloropropyl)-4-methyl-1,3-thiazole
• CAS: 6469-36-9
• 化学式: C₇H₁₀ClNS
• mdl: MFCD00868421
• 分子量: 175.682
• InChiKey: HMKQACOWZYBTIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2934100090

反应信息

• 作为反应物：
  描述：

  氯普噻唑 在 碘 作用下， 以 四氯化碳 为溶剂， 生成 cloprothiazol-I2
  参考文献：
  名称：

  Lagorce, Jean-Francois; Buxeraud, Jacques; Jambut-Absil, Anne-Catherine, Heterocycles, 1990, vol. 31, # 9, p. 1609 - 1615

  摘要：

  DOI：

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Topical composition of antibiotics for application to the mucosa
  申请人：WARNER LAMBERT HOLLAND B.V.

  公开号：EP0125759A2

  公开（公告）日：1984-11-21

  A pharmacologically acceptable aqueous composition for topical application to the skin and the mucosa contains an antibiotic and a hydrocolloid polymer comprising sulphated polygalactoside having a molecular weight of from 10,000 to 20,000 as a fixative agent for the antibiotic.

  一种用于皮肤和粘膜局部涂抹的药理上可接受的水性组合物含有一种抗生素和一种水胶体聚合物，该聚合物由分子量在 10,000 到 20,000 之间的硫酸化聚半乳糖苷组成，作为抗生素的固定剂。
• Controlled absorption water-soluble pharmaceutically active organic compound formulation for once-daily administration
  申请人：Counts David F.

  公开号：US10463611B2

  公开（公告）日：2019-11-05

  The present disclosure provides a once-daily water-soluble pharmaceutically active formulation for oral administration. In certain embodiments, the composition comprises a water-soluble pharmaceutically active organic compound incorporated into a small particulate, each particulate having a core of the water-soluble pharmaceutically active organic compound or an acceptable salt thereof in reversible association with a pharmaceutically acceptable drug-binding polymer. The core of the composition being surrounded by an insoluble water permeable membrane that is capable of delaying the dissolution of the pharmaceutically active compound therewithin and providing for extended release of the pharmaceutically active compound. In some embodiments, the formulation of the invention are designed to extend release of the pharmaceutically active organic compound for about 3 hours to about 8 hours, thereby enabling preparation of an extended release formulation for any pharmaceutically active compound with a half-life of from about 16 hours to about 21 hours.

  本公开提供了一种用于口服的每日一次水溶性药用活性制剂。在某些实施方案中，该组合物包括掺入小颗粒中的水溶性药用活性有机化合物，每个颗粒都有一个水溶性药用活性有机化合物或其可接受盐的核心，该核心与药学上可接受的药物结合聚合物可逆结合。组合物的核心由不溶性透水膜包围，该膜能够延迟其中的药用活性化合物的溶解，并延长药用活性化合物的释放时间。在某些实施方案中，本发明的制剂可将药用活性有机化合物的释放时间延长约 3 小时至约 8 小时，从而能够制备半衰期为约 16 小时至约 21 小时的任何药用活性化合物的缓释制剂。
• Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups
  作者：S Smith、G.J. Blackwell、D.A. Demaine、L.G. Garland、H.F. Hodson、R.M. Hyde、A.J. Parke、V.S. Rose、D.A. Sawyer、L Tilling

  DOI：10.1016/0223-5234(96)89161-6

  日期：1996.1

  This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.
• Mechanism of base-induced rearrangement of some quaternized 5-(chloroalkyl)thiazoles. A kinetic study
  作者：Hans Juergen Federsel、Gabor Merenyi

  DOI：10.1021/jo00336a020

  日期：1981.11