COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE
申请人:SHY Therapeutics LLC
公开号:US20170174699A1
公开(公告)日:2017-06-22
Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.
Ruthenium-Catalyzed Divergent Acceptorless Dehydrogenative Coupling of 1,3-Diols with Arylhydrazines: Synthesis of Pyrazoles and 2-Pyrazolines
作者:Yanling Zheng、Yang Long、Huihua Gong、Jiaqi Xu、Chunchun Zhang、Haiyan Fu、Xueli Zheng、Hua Chen、Ruixiang Li
DOI:10.1021/acs.orglett.2c01497
日期:2022.6.3
1,3-diols with arylhydrazines via acceptorless dehydrogenativecoupling reactions to selectively synthesize pyrazoles and 2-pyrazolines were reported, which were based on Ru3(CO)12/NHC-phosphine-phosphine catalytic systems. The reactions featured low catalyst loading, high selectivity, wide substrate scope, and good yields, with only water and hydrogen gas (H2) as the byproducts.
Synthesis of Pyrazoles from 1,3-Diols via Hydrogen Transfer Catalysis
作者:Daniel C. Schmitt、Alexandria P. Taylor、Andrew C. Flick、Robert E. Kyne
DOI:10.1021/acs.orglett.5b00266
日期:2015.3.20
1,3-Diols engage in ruthenium-catalyzed hydrogen transfer in the presence of alkyl hydrazines to provide 1,4-disubstituted pyrazoles. Regioselective synthesis of unsymmetrical pyrazoles from beta-hydroxy ketones is also described.
TSUBOI, MASAKI;TAKEBE, KAZUO;FUJITA, IYOMI, NIPPON KAGAKU KAJSI,(1989) N, S. 302-304
作者:TSUBOI, MASAKI、TAKEBE, KAZUO、FUJITA, IYOMI
DOI:——
日期:——
TISHCHENKO, I. G.;REVINSKIJ, I. F.;PRADIP, HAXAP, DOKL. AN BSSR, 1982, 26, N 1, 53-55
作者:TISHCHENKO, I. G.、REVINSKIJ, I. F.、PRADIP, HAXAP