3-benzyloxy-2-methyl-2-((triisopropylsilanyloxy)methyl)-propan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzyloxy-2-methyl-2-((triisopropylsilanyloxy)methyl)-propan-1-ol
• 英文别名: 2-Methyl-2-(phenylmethoxymethyl)-3-tri(propan-2-yl)silyloxypropan-1-ol
• 化学式: C₂₁H₃₈O₃Si
• 分子量: 366.616
• InChiKey: RLPCUZOKRKSUCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.39
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,1,1-三(羟甲基)乙烷 在 咪唑 、 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 46.0h， 生成 3-benzyloxy-2-methyl-2-((triisopropylsilanyloxy)methyl)-propan-1-ol
  参考文献：
  名称：

  Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology

  摘要：

  Tris-1,1,1-(hydroxymethyl)ethane 1 was converted to a series of mono- and disubstituted derivatives. An indirect protocol for the differentiation of the alcohol groups was employed for the synthesis of partially and fully differentiated 1 containing a protected aldehyde unit. Complete differentiation of the alcohol groups was also achieved using a direct strategy (two steps from 1). The first synthesis of 1,3-dialclehydes derived from 1 is reported in two steps. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.02.056

文献信息

• Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology
  作者：Philip Clarke、Martin J Jeffery、A.James Boydell、Sally Whiting、Bruno Linclau

  DOI：10.1016/j.tet.2004.02.056

  日期：2004.4

  Tris-1,1,1-(hydroxymethyl)ethane 1 was converted to a series of mono- and disubstituted derivatives. An indirect protocol for the differentiation of the alcohol groups was employed for the synthesis of partially and fully differentiated 1 containing a protected aldehyde unit. Complete differentiation of the alcohol groups was also achieved using a direct strategy (two steps from 1). The first synthesis of 1,3-dialclehydes derived from 1 is reported in two steps. (C) 2004 Elsevier Ltd. All rights reserved.