2-methyl-2-((triisopropylsilanyloxy)methyl)-propane-1,3-diol | 700817-52-3

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 2-methyl-2-((triisopropylsilanyloxy)methyl)-propane-1,3-diol
• 英文别名: 2-Methyl-2-[tri(propan-2-yl)silyloxymethyl]propane-1,3-diol
• CAS: 700817-52-3
• 化学式: C₁₄H₃₂O₃Si
• 分子量: 276.492
• InChiKey: RZAVMYZUWRLSAD-UHFFFAOYSA-N

物化性质

• 沸点：
  342.0±32.0 °C(Predicted)
• 密度：
  0.928±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.17
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 2-methyl-2-((triisopropylsilanyloxy)methyl)-propane-1,3-diol 在 cerium(III) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以89%的产率得到3-acetyloxy-2-methyl-2-((triisopropylsilanyloxy)methyl)-propan-1-ol
  参考文献：
  名称：

  Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology

  摘要：

  Tris-1,1,1-(hydroxymethyl)ethane 1 was converted to a series of mono- and disubstituted derivatives. An indirect protocol for the differentiation of the alcohol groups was employed for the synthesis of partially and fully differentiated 1 containing a protected aldehyde unit. Complete differentiation of the alcohol groups was also achieved using a direct strategy (two steps from 1). The first synthesis of 1,3-dialclehydes derived from 1 is reported in two steps. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.02.056
• 作为产物：
  描述：

  1,1,1-三(羟甲基)乙烷 、 三异丙基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以81%的产率得到2-methyl-2-((triisopropylsilanyloxy)methyl)-propane-1,3-diol
  参考文献：
  名称：

  Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology

  摘要：

  Tris-1,1,1-(hydroxymethyl)ethane 1 was converted to a series of mono- and disubstituted derivatives. An indirect protocol for the differentiation of the alcohol groups was employed for the synthesis of partially and fully differentiated 1 containing a protected aldehyde unit. Complete differentiation of the alcohol groups was also achieved using a direct strategy (two steps from 1). The first synthesis of 1,3-dialclehydes derived from 1 is reported in two steps. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.02.056

文献信息

• Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology
  作者：Philip Clarke、Martin J Jeffery、A.James Boydell、Sally Whiting、Bruno Linclau

  DOI：10.1016/j.tet.2004.02.056

  日期：2004.4

  Tris-1,1,1-(hydroxymethyl)ethane 1 was converted to a series of mono- and disubstituted derivatives. An indirect protocol for the differentiation of the alcohol groups was employed for the synthesis of partially and fully differentiated 1 containing a protected aldehyde unit. Complete differentiation of the alcohol groups was also achieved using a direct strategy (two steps from 1). The first synthesis of 1,3-dialclehydes derived from 1 is reported in two steps. (C) 2004 Elsevier Ltd. All rights reserved.