[10-(tert-Butyl-dimethyl-silanyloxy)-decyl]-(2,5-dimethoxy-phenyl)-amine | 907218-94-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [10-(tert-Butyl-dimethyl-silanyloxy)-decyl]-(2,5-dimethoxy-phenyl)-amine
• CAS: 907218-94-4
• 化学式: C₂₄H₄₅NO₃Si
• 分子量: 423.712
• InChiKey: ODAQZTOLGIFTTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.26
• 重原子数：
  29.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  39.72
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  [10-(tert-Butyl-dimethyl-silanyloxy)-decyl]-(2,5-dimethoxy-phenyl)-amine 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 10-(2,5-dimethoxyphenylamino)decan-1-ol
  参考文献：
  名称：

  Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth

  摘要：

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.027
• 作为产物：
  描述：

  1,10-癸二醇 在 咪唑 、 正丁基锂 、 氢溴酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 环己烷 为溶剂， 反应 10.0h， 生成 [10-(tert-Butyl-dimethyl-silanyloxy)-decyl]-(2,5-dimethoxy-phenyl)-amine
  参考文献：
  名称：

  Solid-phase synthesis of quinol fatty alcohols, design of N/O-substituted quinol fatty alcohols and comparative activities on axonal growth

  摘要：

  Following the promising activity of Q(2)FA15 on axonal growth, two new series of N/O-substituted QFAs were synthesized, based on a S(N)2-type reaction. O-alkylated QFA bearing 14 carbon atoms on the side chain (n = 14) shows a very potent activity on axonal growth though lowered when compared to Q(2)FA15. While O-alkylation allows good retention of the biological activity, N-alkylation abolishes it nonetheless. A solid-phase-supported synthesis of Q(2)FA15 allowing the conception of new hybrid compounds is also described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.027