4-(4-哌啶-1-基苯基)吗啉 | 142827-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 4-(4-哌啶-1-基苯基)吗啉
• 英文名称: 4-(4-(piperidin-1-yl)phenyl)morpholine
• 英文别名: 4-(piperidine-4-ylphenyl)morpholine；4-[4-(Piperidin-1-yl)phenyl]morpholine；4-(4-piperidin-1-ylphenyl)morpholine
• CAS: 142827-42-7
• 化学式: C₁₅H₂₂N₂O
• 分子量: 246.352
• InChiKey: DBDJIVOQTZIVOS-UHFFFAOYSA-N

物化性质

• 沸点：
  426.7±40.0 °C(Predicted)
• 密度：
  1.094±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(4-硝基苯基)吗啉 在 palladium on activated charcoal 氢气 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 4-(4-哌啶-1-基苯基)吗啉
  参考文献：
  名称：

  Preparation and Properties of N,N,N',N'-Tetrasubstituted 1,4-Benzenediamines.

  摘要：

  The synthesis of nine different N,N,N',N'-tetrasubstituted 1,4-benzenediamines is described. These compounds are of interest as mediators for glucose oxidase based biosensors and as donor molecules for conducting molecular solids. The electrochemical behaviour and the electronic absorption spectra have been investigated.

  DOI：

  10.3891/acta.chem.scand.50-1013

文献信息

• A highly efficient precatalyst for amination of aryl chlorides: synthesis, structure and application of a robust acenaphthoimidazolylidene palladium complex
  作者：Tao Tu、Weiwei Fang、Jian Jiang

  DOI：10.1039/c1cc15503b

  日期：——

  A robust palladium NHC complex was synthesized and exhibits exceptional activity and selectivity as a precatalyst in the amination of aryl chlorides and tolerates a wide range of substrates at low catalyst loadings.

  合成了一种稳健的钯NHC复合物，并在芳基氯化物的氨基化反应中作为前催化剂表现出卓越的活性和选择性，并且在低催化剂用量下能够容忍多种底物。
• Palladium-Catalyzed Amination of Aryl Sulfides with Aliphatic Amines
  作者：Ke Gao、Hideki Yorimitsu、Atsuhiro Osuka

  DOI：10.1002/ejoc.201500226

  日期：2015.4

  Conditions for the palladium–NHC-catalyzed amination of aryl sulfides with aliphatic as well as aromatic amines were established. The KHMDS-mediated amination of heteroaryl sulfides could proceed without palladium. Based on the distinct difference in reactivity of C–Br and C–S bonds, a sequential amination of bromothioanisole can take place to install two different alkylamino groups onto the aromatic

  建立了钯-NHC 催化芳基硫化物与脂肪族和芳香族胺胺化的条件。KHMDS 介导的杂芳基硫化物胺化可以在没有钯的情况下进行。基于 C-Br 和 C-S 键反应性的明显差异，可以发生溴苯甲醚的顺序胺化，将两个不同的烷基氨基安装在一个锅中的芳环上。
• Novel robust benzimidazolylidene palladium complexes: synthesis, structure, and catalytic applications in amination of chloroarenes
  作者：Weiwei Fang、Jian Jiang、Yong Xu、Juefei Zhou、Tao Tu

  DOI：10.1016/j.tet.2012.11.003

  日期：2013.1

  A series of novel pyridine stabilized Pd-NHC complexes were developed, which revealed high activities and broad substrates tolerance in the amination of various (hetero)-aryl chlorides. Besides various secondary amines, a wide range of primary anilines and aliphatic amines were also well tolerated. The results highlight us a new strategy to increase catalyst activity in the future catalyst design by alternating the sigma-donor property and flexibility of NHC ligands. (C) 2012 Elsevier Ltd. All rights reserved.
• Buchwald–Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N-Heterocyclic Carbene/Palladium(II) Precatalyst
  作者：Yin Zhang、Guy Lavigne、Vincent César

  DOI：10.1021/acs.joc.5b01272

  日期：2015.8.7

  The cross-coupling of aryl tosylates with amines and anilines was achieved by using for the first time a Pd-NHC system based on the popular Pd-PEPPSI precatalyst platform in which the anchoring imidazol-2-ylidene ligand IPr(Nme2)2 incorporates two dimethylamino groups as backbone substituents enhancing both the electronic and steric properties of the carbene. The system optimization and its application scope are disclosed.
• USE OF BENZENE DERIVATIVES AS CHARGE TRANSFER MEDIATORS
  申请人：NOVO NORDISK A/S

  公开号：EP0552223A1

  公开（公告）日：1993-07-28