4-(3-羟基丁基)苯-1,2-二醇 | 61152-58-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 4-(3-羟基丁基)苯-1,2-二醇
• 英文名称: 4-(3',4'-dihydroxyphenyl)-2-butanol
• 英文别名: 4-(3-Hydroxybutyl)benzene-1,2-diol
• CAS: 61152-58-7
• 化学式: C₁₀H₁₄O₃
• mdl: MFCD21324607
• 分子量: 182.219
• InChiKey: BCSAQTFHGURJII-UHFFFAOYSA-N

物化性质

• 沸点：
  372.6±27.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  硫酸二甲酯 、 4-(3-羟基丁基)苯-1,2-二醇 在 sodium hydroxide 作用下， 反应 2.0h， 以10 mg的产率得到3,4-Dimethoxy-(3'-hydroxybutyl)-benzol
  参考文献：
  名称：

  Phenolic metabolites of the bird's nest fungus Nidula niveo-tomentosa

  摘要：

  DOI：

  10.1016/s0031-9422(00)83949-7
• 作为产物：
  描述：

  姜酮 在 lithium aluminium tetrahydride 、 三溴化硼 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 生成 4-(3-羟基丁基)苯-1,2-二醇
  参考文献：
  名称：

  Very long-chain phenylpropyl and phenylbutyl esters from Taxus baccata needle cuticular waxes

  摘要：

  The cuticular wax of Taxus baccata L. needles was found to contain four different classes of long-chain esters that were identified by various chemical transformations with product assignment employing GC-MS. Homologous series of (1) 3-(4'-hydroxyphenyl)propyl esters Of C-20-C-36 fatty acids, (2) 4-(4-hydroxyphenyl)-2-butyl esters Of C-18-C-28 fatty acids, (3) 3-(3',4'-dihydroxyphenyl)propyl esters Of C-20-C-32 fatty acids, and (4) 4-(3',4-dihydroxyphenyl)-2-butyI esters Of C-18-C-28 fatty acids were identified. The four compound classes amounted to 0.1-3.6 mug/cm(2) of needle surface area, corresponding to 0.2-7.6% of the wax mixture, respectively. While both phenylpropyl ester series had a maximum for the homolog containing tetracosanoic acid, in the phenylbutyl esters homologs containing eicosanoic and docosanoic acids predominated. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(02)00286-8

文献信息

• Compositions for weight loss with improved taste
  申请人：Kanebo, Ltd.

  公开号：US20040076690A1

  公开（公告）日：2004-04-22

  The present invention relates to compositions comprising compounds that induce weight and fat loss and compounds that mask the bitter and harsh taste of the composition. The invention further relates to a food, beverage, dietary supplement, medical food, or pet food comprising compounds that induce weight loss and compounds that mask the bitter and harsh taste of the product. The invention is further related to methods of reducing or controlling weight by administering such compositions. Further provided are cosmetic sheets for topical administration of compositions for inducing weight and fat loss.

  本发明涉及包含诱导体重和脂肪减少化合物以及掩盖配方的苦味和刺激味的化合物的组合物。本发明还涉及包含诱导减重化合物和掩盖产品的苦味和刺激味的食品、饮料、膳食补充剂、医学食品或宠物食品。本发明还涉及通过给予这种组合物来减轻或控制体重的方法。此外，还提供用于诱导体重和脂肪减少的组合物的局部给药的化妆品片。
• Verwendung von Hydroxydiphenyletherverbindungen zur Behandlung der Haut
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1366757A1

  公开（公告）日：2003-12-03

  Beschrieben wird die Verwendung von (a) Hydroxydiphenyletherverbindungen der Formel worin R1, R2 und R3 unabhängig voneinander Wasserstoff; Hydroxy; C1-C20-Alkyl; hydroxy-substituiertes C1C20-Alkyl; C5-C7-Cycloalkyl; C1-C20-Alkoxy; C1-C6-Alkylcarbonyl; Phenyl; oder Phenyl-C1-C3-Alkyl; R4 Wasserstoff, C1-C20Alkyl; hydroxy-substituiertes C1-C20-Alkyl; C5-C7-Cycloalkyl; Hydroxy; Formyl; Acetonyl; Allyl; Carboxy; Carboxy-C1-C3-Alkyl; Carboxyallyl; C2-C20-Alkenyl; C1-C6-Alkylcarbonyl; C1-C3-Alkylcarbonyl-C1-C3-Alkyl; Phenyl; oder Phenyl-C1-C3-Alkyl; und R5 Wasserstoff; C1-C20-Alkoxy; oder C1-C6-Alkylcarbonyl; bedeuten als Melanogenese-Inhibitor und zum Aufhellen der Haut.

  使用 (a) 式中的羟基二苯醚化合物 其中 R1、R2 和 R3 相互独立地为氢；羟基；C1-C20 烷基；羟基取代的 C1-C20 烷基；C5-C7 环烷基；C1-C20 烷氧基；C1-C6 烷基羰基；苯基；或苯基-C1-C3 烷基； R4 氢、C1-C20烷基、羟基取代的 C1-C20烷基、C5-C7 环烷基、羟基、甲酰基、丙酮基、烯丙基、羧基、羧基-C1-C3 烷基、羧基烯丙基、C2-C20烯基、C1-C6 烷基羰基、C1-C3 烷基羰基-C1-C3 烷基、苯基或苯基-C1-C3 烷基；和 R5 是氢；C1-C20 烷氧基；或 C1-C6 烷基羰基；以及 作为黑色素生成抑制剂和美白剂。
• LIPOLYSIS ACCELERATOR, COSMETIC SKIN PREPARATION FOR BODY WEIGHT REDUCTION AND FOOD OR BEVERAGE COMPOSITION EACH CONTAINING THE SAME, AND METHOD FOR REDUCING BODY WEIGHT AND MEDICINAL USE EACH BASED ON ACTIVITY OF THE SAME
  申请人：Kanebo, Limited

  公开号：EP1402886A1

  公开（公告）日：2004-03-31

  The present invention provides a lipolysis promoter which has a satisfactory versatility with no peculiar odor or taste, an effect of reforming obese constitution by reducing general and topical fat tissues, or an anti-obesity effect by preventing increase of the fat tissues. The present invention also provides a cosmetic composition comprising the same, a food or drink composition comprising the same, a method for reducing body weight based on lipolitic function of the same and a drug comprising the same. The present lipolysis promoter comprising as an active ingredient a compound represented by the following formula (1): wherein Z is a group represented by the formula (2) or (3), and either of R1 and R2 is a hydrogen atom and the other is a hydrogen atom or a glucose residue.

  本发明提供了一种脂肪分解促进剂，它具有令人满意的多功能性，无异味或异味，通过减少全身和局部脂肪组织而具有改造肥胖体质的效果，或通过防止脂肪组织增加而具有抗肥胖效果。本发明还提供了一种包含该成分的化妆品组合物、一种包含该成分的食品或饮料组合物、一种基于该成分的脂肪分解功能的减轻体重方法以及一种包含该成分的药物。本发明的脂肪分解促进剂包括下式（1）所代表的化合物作为活性成分： 其中 Z 是由式（2）或（3）代表的基团、 R1和R2中的一个是氢原子，另一个是氢原子或葡萄糖残基。
• Use of guaiol for treating the skin
  申请人：Baschong Werner

  公开号：US20050058610A1

  公开（公告）日：2005-03-17

  The use is described of compositions comprising (a) (−)-guaiol, (b) further skin-lightening active substance(s) and, optionally, (c) one or more UV-A and/or UV-B absorbers as melanogenesis inhibitors and for skin-lightening.

  所述组合物的用途包括：(a) (-)- 愈创木酚；(b) 其他皮肤美白活性物质；(c) 一种或多种 UV-A 和/或 UV-B 吸收剂，作为黑色素生成抑制剂和皮肤美白剂。
• Dihydroxyphenyl compounds and glucoside compounds thereof
  申请人：Yokota Tomohiro

  公开号：US20060120978A1

  公开（公告）日：2006-06-08

  A skin cosmetic composition comprising the compound represented by the following formula (1): wherein R 1 is hydrogen and R 2 is hydrogen or glucose residue.

  一种皮肤化妆品组合物，包含下式(1)所代表的化合物： 其中 R 1 是氢，R 2 是氢或葡萄糖残基。