2,6-二氯-4-苯基喹唑啉 | 5185-54-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2,6-二氯-4-苯基喹唑啉
• 英文名称: 2-chloro-4-phenyl-6-chloroquinazoline
• 英文别名: 2,6-dichloro-4-phenylquinazoline；2,6-dichloro-4-phenyl-quinazoline；2,6-dichloro 4-phenyl quinazoline；2,6-Dichlor-4-phenylchhinazolin；2,6-Dichlor-4-phenylchinazolin
• CAS: 5185-54-6
• 化学式: C₁₄H₈Cl₂N₂
• mdl: MFCD00563519
• 分子量: 275.137
• InChiKey: CRVSRCOECJCBAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090
• 储存条件：
  室温

反应信息

• 作为反应物：
  描述：

  2,6-二氯-4-苯基喹唑啉 以 乙醇 为溶剂， 生成 7-chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinazoline
  参考文献：
  名称：

  Triazoloquinazolines

  摘要：

  该公式为Triazoloquinazolines，其中R.sub.1为C.sub.1.sub.-4烷基或芳基；R.sub.2和R.sub.3分别为氢、卤素、三氟甲基、硝基、C.sub.1.sub.-4烷基或C.sub.1.sub.-4烷氧基，或R.sub.2和R.sub.3可形成亚甲二氧基；R.sub.4为氢、C.sub.1.sub.-4烷基、芳基烷基、C.sub.1.sub.-4卤代烷基或C.sub.3.sub.-6环烷基；以及其药学上可接受的酸盐经由以下方式制备：（a）将2-肼基喹唑啉衍生物与羧酸或其反应性衍生物反应，（b）加热2-酰基肼基喹唑啉衍生物进行环化，或（c）将三唑基苯甲酮衍生物与氨反应。所述Triazoloquinazolines及其药学上可接受的酸盐具有优异的抗炎和镇痛活性。

  公开号：

  US04002755A1
• 作为产物：
  描述：

  6-氯-4-苯基喹唑啉-2(1H)-酮 在 三氯氧磷 作用下， 反应 0.67h， 生成 2,6-二氯-4-苯基喹唑啉
  参考文献：
  名称：

  5-芳基-12H-喹唑啉[3,2-a]喹唑啉-12-酮类抗炎药的合成

  摘要：

  4-芳基-2-氯喹唑啉与邻氨基苯甲酸缩合生成5-芳基-12H-喹唑啉[3,2-a]喹唑啉-12-酮。研究了它们的质谱碎片。测试了其中一些化合物的镇痛和抗炎活性。

  DOI：

  10.1002/ardp.19833160811

文献信息

• [EN] 4-ARYLQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS<br/>[FR] DÉRIVÉS DE 4-ARYLQUINAZOLINE EN TANT QU'INHIBITEURS DE LA MÉTHIONINE ADÉNOSYLTRANSFÉRASE 2A
  申请人：IDEAYA BIOSCIENCES INC

  公开号：WO2021252680A1

  公开（公告）日：2021-12-16

  Disclosed herein are certain 4-arylquinazoline derivatives of Formula (I) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

  本文披露了某些Formula (I)的4-芳基喹唑啉衍生物，它们是蛋氨酸腺苷转移酶2A（MAT2A）抑制剂。还披露了包含这些化合物的药物组合物以及治疗MAT2A抑制剂可治疗的疾病的方法，如癌症，包括特征为甲硫腺苷磷酸化酶（MTAP）活性降低或缺失的癌症。
• Fused quinazolinones and preparation thereof
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04183932A1

  公开（公告）日：1980-01-15

  Tricyclic quinazolines of the formula, ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are as defined in the specification, such as 4,5-dihydro-5-arylimidazo[1,2-a]quinazolines, 4,5-dihydro-5-aryl-s-triazolo[4,3-a]quinazolines and 4,5-dihydro-5-aryltetrazolo[1,5-a]quinazolines having anti-inflammatory and analgesic activity are, for example, prepared by reducing the corresponding 4,5-unsaturated compounds, and then, if necessary, by alkylating the thus produced compounds.

  公式为##STR1##的三环喹唑啉化合物，其中R.sub.1、R.sub.2、R.sub.3、R.sub.4和A如规范中所定义，例如4,5-二氢-5-芳基咪唑[1,2-a]喹唑啉、4,5-二氢-5-芳基-s-三唑[4,3-a]喹唑啉和4,5-二氢-5-芳基四唑[1,5-a]喹唑啉具有抗炎和镇痛活性，例如通过还原相应的4,5-不饱和化合物制备，然后必要时通过烷基化所产生的化合物。
• AGENT FOR INHIBITING CYTOKININ SIGNALING
  申请人：Nagasawa Asako

  公开号：US20100056377A1

  公开（公告）日：2010-03-04

  Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical substance capable of promoting the growth of a root of a plant, which comprises measuring the level of intracellular signaling from the receptor in a system where a cell having the receptor is contacted with a chemical substance having an agonistic activity on the receptor and a substance to be tested, comparing the level of intracellular signaling measured in the preceding step with a level of intracellular signaling measured in the absence of the chemical substance, and determining the chemical substance as being a chemical substance capable of promoting the growth of a root of a plant based on the difference obtained by the comparison; and others.

  本发明涉及一种具有抑制植物来源细胞因子受体内部信号传递活性的物质，可控制植物的生长或分化。同时，还揭示了一种搜寻促进植物根生长的化学物质的方法，其中包括测量具有激动剂活性的化学物质与待测试物质接触的受体细胞系统中的细胞内信号传递水平，将前一步骤中测量的细胞内信号传递水平与无化学物质存在时测量的细胞内信号传递水平进行比较，并根据所得到的差异确定该化学物质为能够促进植物根生长的化学物质。
• Agent for inhibiting cytokinin signaling
  申请人：Nagasawa Asako

  公开号：US08722580B2

  公开（公告）日：2014-05-13

  Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical substance capable of promoting the growth of a root of a plant, which comprises measuring the level of intracellular signaling from the receptor in a system where a cell having the receptor is contacted with a chemical substance having an agonistic activity on the receptor and a substance to be tested, comparing the level of intracellular signaling measured in the preceding step with a level of intracellular signaling measured in the absence of the chemical substance, and determining the chemical substance as being a chemical substance capable of promoting the growth of a root of a plant based on the difference obtained by the comparison; and others.

  本发明公开了一种具有抑制植物源细胞因子受体内部信号传递活性的物质，可以控制植物的生长或分化。此外，还公开了一种搜索能够促进植物根生长的化学物质的方法，该方法包括测量具有激动剂活性的化学物质和待测试物质接触的具有受体的细胞系统中受体内部信号传递水平，将前一步骤中测量的内部信号传递水平与没有化学物质时测量的内部信号传递水平进行比较，并根据比较得到的差异确定该化学物质为能够促进植物根生长的化学物质。
• COMPOUND, ORGANIC ELECTROLUMINESCENCE ELEMENT MATERIAL, INK COMPOSITION, ORGANIC ELECTROLUMINESCENCE ELEMENT, ELECTRONIC DEVICE, AND METHOD FOR PRODUCING COMPOUND
  申请人：IDEMITSU KOSAN CO., LTD.

  公开号：US20160197288A1

  公开（公告）日：2016-07-07

  A compound represented by formula (1): wherein *a, *b, R 1 , X 1 , L 1 , L 2 , n, A 1 , and A 2 are as defined in the description, and a production method of the compound represented by formula (1) are provide. In the production method, A 1 is introduced under a reaction condition in which the reactivity of Hal 2 in a compound represented by formula (I): wherein *c, *d, R 1 , X 1 , L 1 , L 2 , n, A 1 , A 2 , Hal 1 , and Hal 2 are as defined in the description, is extremely low as compared with that of Hal 1 and then A 2 which is different from A 1 is introduced under a reaction condition in which the reactivity of Hal 2 is high. The compound represented by formula (1) is formed into a layer by a coating method and meets various performance requirements of an organic EL device.

  公式（1）所表示的化合物：其中*a，*b，R1，X1，L1，L2，n，A1和A2的定义如说明书中所定义，并且提供了化合物（1）的生产方法。在生产方法中，A1在反应条件下引入，其中在化合物（I）所表示的卤素2的反应性在Hal1相比下极低，其中* c，* d，R1，X1，L1，L2，n，A1，A2，Hal1和HaL2的定义如说明书中所定义，然后在HaL2的反应性高的反应条件下引入不同于A1的A2。化合物（1）通过涂覆方法形成一层，并满足有机EL器件的各种性能要求。