4,4'-Bis-dimethylamino-4''-nitro-tritylium | 16044-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-Bis-dimethylamino-4''-nitro-tritylium
• 英文别名: (4-Nitro-phenyl)-bis-(4-dimethylamino-phenyl)-carbenium；p-Nitro-Malachit-Gruen；4-Nitro-malachitgruen；p-Nitro-malachitgruen；[4-[[4-(Dimethylamino)phenyl]-(4-nitrophenyl)methylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium
• CAS: 16044-05-6；34101-52-5
• 化学式: C₂₃H₂₄N₃O₂
• 分子量: 374.462
• InChiKey: LARAPNXGSSZIIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,4'-Bis-dimethylamino-4''-nitro-tritylium 在 三氧化硫 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Sinev, V. V.; Ivanov, Yu. E., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 10, p. 1866 - 1870

  摘要：

  DOI：
• 作为产物：
  描述：

  在 hydroxide 作用下， 生成 4,4'-Bis-dimethylamino-4''-nitro-tritylium 、 2-巯基乙醇
  参考文献：
  名称：

  Cation-anion combination reactions. 17. Reactivities of alkylthiolate ions in aqueous solution

  摘要：

  DOI：

  10.1021/ja00518a030

文献信息

• TARGETED PROBES OF CELLULAR PHYSIOLOGY
  申请人：Waggoner Alan

  公开号：US20130244891A1

  公开（公告）日：2013-09-19

  Biosensor comprising an activatable acceptor fluorogen linked via a linker to a donor which transfers energy to the fluorogen on detecting an analyte wherein the fluorogen component reacts and a 100 fold increase in intensity results when the fluorogen interacts non-covalently with an activator e.g. fluorogen activator peptide.

  生物传感器包括一个可激活的受体荧光原料，通过连接到一个供体的链段，该供体在检测到分析物时向荧光原料转移能量，其中荧光原料组分反应，并且当荧光原料与激活剂（如荧光原料激活肽）非共价地相互作用时，强度增加100倍。
• Sinev, V. V.; Nikolova, T. A., Journal of Organic Chemistry USSR (English Translation), 1984, vol. 20, p. 707 - 713
  作者：Sinev, V. V.、Nikolova, T. A.

  DOI：——

  日期：——
• Sinev, V. V.; Ivanov, Yu. E., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 10, p. 1870 - 1875
  作者：Sinev, V. V.、Ivanov, Yu. E.

  DOI：——

  日期：——
• Sinev, V. V.; Smirnova, E. N., Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 1070 - 1072
  作者：Sinev, V. V.、Smirnova, E. N.

  DOI：——

  日期：——
• Quenched Dendrimeric Dyes for Florescence Detection
  申请人：Bruchez Marcel P.

  公开号：US20120058494A1

  公开（公告）日：2012-03-08

  The present invention presents designs for high extinction quenched “dyedrons” that can be activated by conversion of a single acceptor/quencher in the molecular assembly to a fluorescent state. The quencher is activated by noncovalent binding to a unique complementary expressible fluorogen activating peptide (FAP). In this way, the quencher serves as the homogeneous switch, receiving energy efficiently from each of the donor molecules of the dendronic antenna, and releasing it as fluorescence only when activated by binding. The sum of the extinction of the multiple dyes on the antenna will provide dramatic enhancements in the effective brightness of the probe in standard imaging systems. This approach provides a set of probes with exceptional brightness, specifically targeted to an expressed tag that activates the fluorescence of the dyedron.