6-nitrohexan-1-amine | 132124-24-4

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 6-nitrohexan-1-amine
• 英文别名: 6nitro-n-hexylamine
• CAS: 132124-24-4
• 化学式: C₆H₁₄N₂O₂
• 分子量: 146.189
• InChiKey: JGSSXJVGISIKRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-nitrohexan-1-amine 、 三苯甲基奥美沙坦酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以60%的产率得到
  参考文献：
  名称：

  Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation

  摘要：

  Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters of IIa were studied and compared with those of olmesartan medoxomil. Compound IIa is proposed to be a promising prodrug of olmesartan. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.07.089
• 作为产物：
  描述：

  1-azido-6-nitrohexane 在 水 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以85%的产率得到6-nitrohexan-1-amine
  参考文献：
  名称：

  Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation

  摘要：

  Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters of IIa were studied and compared with those of olmesartan medoxomil. Compound IIa is proposed to be a promising prodrug of olmesartan. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.07.089

文献信息

• Novel diamine compounds, production of the same and polyamideimide
  申请人：Tomoegawa Paper Co., Ltd.

  公开号：US05019642A1

  公开（公告）日：1991-05-28

  A diamine compound represented by general formula (I): ##STR1## wherein R is as defined in the specification a group of formula (II) ##STR2## where R.sup.1 and R.sup.2 as defined in the specification or a group of formula (III) ##STR3## where R.sup.1 and R.sup.2 have the same meanings as defined above, and Z is as defined in the specification, or --SO.sub.2 --. The diamine compound is produced by reducing a dinitro compound of general formula (IV) ##STR4## wherein R has the same meaning as defined above. Imidation of the diamine compound with a tetracarboxylic acid dianhydride produces a polyamideimide resin having a repeating unit represented by general formula (V): ##STR5## wherein Ar and Ar.sup.1, which are as defined in the specification R.sup.3 is a group of general formula (VI) below: ##STR6## where R has the same meaning as defined above; R.sup.4 is as defined in the specification and m and n are each zero or a positive integer which satisfy m.gtoreq.2n.

  通用式（I）表示的二胺化合物：其中R如规范中定义的公式（II）中的一个基团##STR2##其中R.sup.1和R.sup.2如规范中定义或公式（III）中的一个基团##STR3##其中R.sup.1和R.sup.2具有与上述定义相同的含义，Z如规范中定义，或者--SO.sub.2--。该二胺化合物通过还原通用式（IV）中的二硝基化合物生产：##STR4##其中R具有与上述定义相同的含义。将该二胺化合物与四羧酸酐酸二酐进行咪唑化反应，产生一个重复单元由通用式（V）表示的聚酰亚胺树脂：##STR5##其中Ar和Ar.sup.1如规范中定义，R.sup.3是下面的通用式（VI）中的一个基团：##STR6##其中R具有与上述定义相同的含义；R.sup.4如规范中定义，m和n均为零或满足m≥2n的正整数。
• Novel diamine compounds, production of the same and polyamideimide resins produced therefrom
  申请人：TOMOEGAWA PAPER CO. LTD.

  公开号：EP0387106B1

  公开（公告）日：1994-02-02
• US5019642A
  申请人：——

  公开号：US5019642A

  公开（公告）日：1991-05-28
• Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation
  作者：Jin-Hun Park、Jeong-Soo Chang、Mohammed I. El-Gamal、Won-Kyoung Choi、Woong San Lee、Hye Jin Chung、Hyun-Il Kim、Young-Jin Cho、Bong Sang Lee、Hong-Ryeol Jeon、Yong Sup Lee、Young Wook Choi、Jaehwi Lee、Chang-Hyun Oh

  DOI：10.1016/j.bmcl.2010.07.089

  日期：2010.10

  Synthesis of novel amides and esters prodrugs of olmesartan is described. Their in vitro stability in rat plasma was tested. The results showed that the ester derivative IIa with n-octyl substituted dioxolone moiety was rapidly converted into olmesartan within 30 min. The pharmacokinetic parameters of IIa were studied and compared with those of olmesartan medoxomil. Compound IIa is proposed to be a promising prodrug of olmesartan. (C) 2010 Published by Elsevier Ltd.