6-溴-N-(1-甲基乙基)-2-吡啶胺 | 89026-81-3

• 物质功能分类: 医药中间体 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-溴-N-(1-甲基乙基)-2-吡啶胺
• 英文名称: (6-bromopyridin-2-yl)-isopropyl-amine
• 英文别名: 6-Bromo-2-isopropylaminopyridine；6-bromo-N-propan-2-ylpyridin-2-amine
• CAS: 89026-81-3
• 化学式: C₈H₁₁BrN₂
• 分子量: 215.093
• InChiKey: FZACLMVHJVRFML-UHFFFAOYSA-N

物化性质

• 沸点：
  290℃
• 密度：
  1.417
• 闪点：
  129℃

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090
• 储存条件：
  存于室温下，密封保存，并保持干燥。

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 6-Bromo-2-isopropylaminopyridine
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 6-Bromo-2-isopropylaminopyridine
CAS number: 89026-81-3

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H11BrN2
Molecular weight: 215.1

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,6-二乙基苯胺 、 6-溴-N-(1-甲基乙基)-2-吡啶胺 在 palladium diacetate 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 为溶剂， 以5.6 %的产率得到N²-(2,6-diethylphenyl)-N⁶-isopropylpyridine-2,6-diamine
  参考文献：
  名称：

  Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas

  摘要：

  DOI：

  10.1021/acsmedchemlett.3c00162
• 作为产物：
  描述：

  6-溴-2-叔丁氧羰基氨基吡啶 在 sodium hydride 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 21.5h， 生成 6-溴-N-(1-甲基乙基)-2-吡啶胺
  参考文献：
  名称：

  [EN] BIARYL DERIVATIVES AS GPR120 AGONISTS
  [FR] DÉRIVÉS DE BIARYLE EN TANT QU'AGONISTES DE GPR120

  摘要：

  本发明涉及公式1的联苯衍生物，一种制备该联苯衍生物的方法，包含该联苯衍生物的药物组合物以及其用途。根据本发明的公式1的联苯衍生物促进胃肠道中GLP-1的形成，并由于巨噬细胞、脂肪细胞等中的抗炎作用改善肝脏或肌肉中的胰岛素抵抗，因此可有效用于预防或治疗糖尿病、糖尿病并发症、肥胖、非酒精性脂肪肝、脂肪性肝炎、骨质疏松症或炎症。

  公开号：

  WO2014209034A1

文献信息

• A practical synthesis of substituted 2,6-diaminopyridines via microwave-assisted copper-catalyzed amination of halopyridines
  作者：Matthias Mastalir、Egon E. Rosenberg、Karl Kirchner

  DOI：10.1016/j.tet.2015.08.042

  日期：2015.10

  selective substitution of one or two halogens by aryl or alkylamines was achieved within 2–6 h with temperatures between 80 and 225 °C affording 2,6-diaminopyridines in good to excellent isolated yields. The reaction allows easy variation between educts and different N-substitutions. The target compounds are valuable precursors for the synthesis of bis-phosphorylated 2,6-diaminopyridines which are

  据报道，利用一系列的2，6-二卤代和2-氨基-6-卤代吡啶前体，进行了微波辅助的铜催化的胺化反应。使用该方法，被芳基或烷基胺一个或两个卤素选择性取代物2-6小时内用80和225之间的温度下℃下，得到良好的2,6-二氨基吡啶，以优异的分离产率来实现的。该反应允许离析物和不同之间容易变化Ñ -substitutions。目标化合物可用于被用作过渡金属络合物PNP钳配体的双-磷酸化2,6-二氨基吡啶合成有价值的前体。
• 2-Alkylaminopyridine derivatives
  申请人：Toyo Soda Manufacturing Co. Ltd.

  公开号：US04560762A1

  公开（公告）日：1985-12-24

  2-Alkylaminopyridine derivatives represented by a general formula of ##STR1## wherein R denotes a lower alkyl group and Y denotes a methoxy group or a halogen atom, and method for producing the same.

  2-烷基氨基吡啶衍生物的一般公式为##STR1##其中R代表较低的烷基，Y代表甲氧基或卤素原子，以及其制备方法。
• 2-chloro or bromo-6-C.sub.1 C.sub.3 -alkylamino-pyridine intermediates
  申请人：Toyo Soda Manufacturing Co., Ltd.

  公开号：US04617397A1

  公开（公告）日：1986-10-14

  2-Alkylaminopyridine derivatives represented by the general formula ##STR1## wherein R denotes a lower alkyl group and Y denotes a halogen atom, and a process for producing the same. These compounds are useful as intermediates in medicines and agricultural chemicals. The final products prepared from the intermediates of the invention are especially useful as herbicides for use in paddy fields and farmlands.

  2-烷基氨基吡啶衍生物的一般式表示为##STR1##其中R表示低碳基团，Y表示卤素原子，并提供了一种制备它们的方法。这些化合物在药物和农药中作为中间体非常有用。从本发明的中间体制备的最终产品特别适用于水稻田和农田中的除草剂。
• US4560762A
  申请人：——

  公开号：US4560762A

  公开（公告）日：1985-12-24
• US4617397A
  申请人：——

  公开号：US4617397A

  公开（公告）日：1986-10-14