2-(RS)-N,N-dimethyl-2-phenyl-2-(N'-phenylimino)acetamide | 93018-96-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(RS)-N,N-dimethyl-2-phenyl-2-(N'-phenylimino)acetamide
• 英文别名: N,N-dimethyl-α-(phenylamino)benzeneacetamide；(+/-)-α-Anilino-phenylessigsaeure-dimethylamid；2-anilino-N,N-dimethyl-2-phenylacetamide
• CAS: 93018-96-3
• 化学式: C₁₆H₁₈N₂O
• 分子量: 254.332
• InChiKey: ZADYNVYSFBSJIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-苯甲酰替苯胺 在 bis(tri-tert-butylphosphine)palladium⁽⁰⁾ 2,6-二甲基吡啶 、 sodium tetrahydroborate 、 草酰氯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 6.5h， 生成 2-(RS)-N,N-dimethyl-2-phenyl-2-(N'-phenylimino)acetamide
  参考文献：
  名称：

  Palladium-Catalyzed Synthesis of α-Iminoamides from Imidoyl Chlorides and a Carbamoylsilane

  摘要：

  A series of pure imidoyl chlorides were converted into alpha-iminoamides by treatment with a carbamoylsilane under catalysis by palladium(0) complexes.

  DOI：

  10.1021/jo050545h

文献信息

• A New Synthesis of 1,4-Diaryl-1,3-butadienes Utilizing the Anil Synthesis
  作者：M. Paventi、A. S. Hay

  DOI：10.1055/s-1990-27039

  日期：——

  The anil synthesis was employed in the preparation of 1,4-diarylsubstituted 1,3-butadienes 7 from 1-arylpropenes 5 and N- arylideneanilines (aromatic Schiff bases) 6 in dimethylformamide solution and a strong base as catalyst obtained in situ by reacting metallic sodium with this solvent.

  苯胺合成法用于在二甲基甲酰胺溶液中，以一种强碱作为催化剂，现场通过将金属钠与该溶剂反应得到，从1-芳基丙烯5和N-芳基亚胺苯胺（芳香Schiff碱）6制备1,4-二芳基取代的1,3-丁二烯7。
• Concise synthesis of semicarbazides and formylhydrazines via direct addition reaction between aromatic azoarenes and N-substituted formamides
  作者：Defu Liu、Jincheng Mao、Guangwei Rong、Hong Yan、Yang Zheng、Jie Chen

  DOI：10.1039/c4ra17015f

  日期：——

  The addition reactions between aromatic azoarenes and N-substituted formamides are described. This direct and practical method provides a novel approach for the synthesis of formylhydrazines and semicarbazides in the presence of NaI/DTBP and imidazole/DCP catalytic systems, respectively. It can be seen that C–H or C–N from N-substituted formamides could be cleaved selectively under such transition-metal-free

  描述了芳族偶氮芳烃和N-取代的甲酰胺之间的加成反应。这种直接而实用的方法分别为在NaI / DTBP和咪唑/ DCP催化体系存在下合成甲酰肼和氨基脲的新颖方法。可以看出，在这种无过渡金属的条件下，N取代的甲酰胺中的CH或CH可以被选择性地裂解。这是将N-取代的甲酰胺直接加成到N N键上的第一个成功的例子。
• Novel synthesis of N,N-diarylarylmethanamines from N-(arylmethylene)arenamines and (arylmethoxy)arenes
  作者：Martino Paventi、Allan S. Hay

  DOI：10.1021/jo00020a032

  日期：1991.9

  Various N,N-diarylarylmethanamines were synthesized by the reaction of N-(arylmethylene)arenamines with (arylmethoxy)arenes in dimethylformamide solution in the presence of a strong base as a catalyst which is obtained in situ by reacting metallic sodium with this solvent. In general, the reaction may be depicted as the reduction of the imine and addition, on the original imino nitrogen atom, of the aryl group (of the aryloxy moiety) of the ether and presumably oxidation of the arylmethoxy group of the either to its corresponding aldehyde. Side reactions and a proposed reaction mechanism are discussed.
• PAVENTI, M.;HAY, A. S., SYNTHESIS,(1990) N0, C. 878-881
  作者：PAVENTI, M.、HAY, A. S.

  DOI：——

  日期：——
• ALBUMIN-BINDING COMPOUNDS THAT PREVENT NONENZYMATIC GLYCATION AND THAT MAY BE USED FOR TREATMENT OF GLYCATION-RELATED PATHOLOGIES
  申请人：EXOCELL, INC.

  公开号：EP1242069A2

  公开（公告）日：2002-09-25