Silver-Catalyzed Carboazidation of Arylacrylamides
作者:Xiao-Hong Wei、Ya-Min Li、An-Xi Zhou、Ting-Ting Yang、Shang-Dong Yang
DOI:10.1021/ol402138y
日期:2013.8.16
inexpensive method of nontoxic, silver-salt-catalyzed carboazidation of arylacrylamides to afford corresponding azide oxindoles is reported. This reaction system exhibits great functional group tolerance. All products form a crucial skeleton for the synthesis of various indole alkaloids.
Iron-catalyzed aerobic difunctionalization of alkenes: a highly efficient approach to construct oxindoles by C–S and C–C bond formation
作者:Tao Shen、Yizhi Yuan、Song Song、Ning Jiao
DOI:10.1039/c4cc00401a
日期:——
A novel iron-catalyzed efficient approach to construct sulfone-containing oxindoles, which play important roles in the structural library design and drug discovery, has been developed. The use of readily available benzenesulfinic acids, an inexpensive iron salt as the catalyst, and air as the oxidant makes this sulfur incorporation protocol very efficient and practical.
Synthesis of Oxindoles through Silver-Catalyzed Trifluoromethylation-, Difluoromethylation- and Arylsulfonylation-Cyclization Reaction of<i>N</i>-Arylacrylamides
作者:Jidan Liu、Shaobo Zhuang、Qingwen Gui、Xiang Chen、Zhiyong Yang、Ze Tan
DOI:10.1002/ejoc.201400087
日期:2014.5
Efficient synthesis of trifluoromethyl and difluoromethyl-substituted oxindoles was achieved by reacting Langlois reagent or Baran reagent with N-arylacrylamides. However, the reaction of aryl sulfinic acid sodium salts with N-arylacrylamides did not give the desulfinative products, instead, aryl sulfonated products were produced.
通过 Langlois 试剂或 Baran 试剂与 N-芳基丙烯酰胺反应,实现了三氟甲基和二氟甲基取代的羟吲哚的有效合成。然而,芳基亚磺酸钠盐与N-芳基丙烯酰胺的反应没有得到脱亚磺化产物,而是产生了芳基磺化产物。
Palladium-Catalyzed Alkylarylation of Acrylamides with Unactivated Alkyl Halides
作者:Hua Wang、Li−Na Guo、Xin-Hua Duan
DOI:10.1021/acs.joc.5b02433
日期:2016.2.5
An efficient palladium-catalyzed alkylarylation of acrylamides with unactivatedalkyl halides has been developed. This method is highlighted by its broad substrate scope and excellent functional group tolerance. In addition to alkyl halides, fluoroalkyl halides and benzyl bromides also participated well in this transformation. A detailed mechanistic investigation suggests that a radical pathway is
Copper-Catalyzed Oxidative Carbamoylation of <i>N</i>
-Arylacrylamides with Hydrazinecarboxamides Leading to 2-(Oxindol-3-yl)acetamide<b>s</b>
作者:Zeng-Yang He、Jing-Yu Guo、Shi-Kai Tian
DOI:10.1002/adsc.201800012
日期:2018.4.3
radical carbamoylation/cyclization reaction of N‐arylacrylamides with hydrazinecarboxamides has been developed for facile access to 2‐(oxindol‐3‐yl)acetamides, which had been utilized as precursors in the synthesis of natural bioactive pyrrolidinoindolines. In the presence of 1 mol% of copper(II) carbonate and 4 equiv. of tert‐butyl hydroperoxide, a wide range of N‐arylacrylamides underwent highly regioselective