甲基(2-chloroethyl)氨基甲酸酯 | 13989-86-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲基(2-chloroethyl)氨基甲酸酯
• 英文名称: 2-chloroethylcarbamic acid methyl ester
• 英文别名: methyl N-(2-chloroethyl)carbamate；methyl 2-chloro-ethylcarbamate；(2-chloro-ethyl)-carbamic acid methyl ester；(2-Chlor-aethyl)-carbamidsaeure-methylester；methyl 2-chloroethylcarbamate；Methyl (2-chloroethyl)carbamate
• CAS: 13989-86-1
• 化学式: C₄H₈ClNO₂
• 分子量: 137.566
• InChiKey: RHGACTQWKOOOFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲基(2-chloroethyl)氨基甲酸酯 生成 2-唑烷酮
  参考文献：
  名称：

  2-OXAZOLIDONES: SYNTHESIS FROM N-CARBALKOXY-β-HALOALKYLAMINES¹

  摘要：

  DOI：

  10.1021/jo01151a025
• 作为产物：
  描述：

  2-氯乙胺盐酸盐 、 氯甲酸甲酯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以64 %的产率得到甲基(2-chloroethyl)氨基甲酸酯
  参考文献：
  名称：

  对映选择性相转移催化合成螺环氮杂环丁烷吲哚

  摘要：

  Spiro-3,2'-azetidine oxindoles 将两个独立重要的药效团结合在一个正在研究的螺环基序中，这对药物化学很有吸引力。在这里，这些结构的对映选择性合成是通过分子内 C-C 键形成在高达 2:98 er 的时间内实现的，涉及用新型含 SF 5的手性阳离子相转移 (PT) 催化剂活化底物。该产品易于精制/脱保护，以提供医学相关的对映体富集化合物。对照实验表明界面 PT 机制，通过活化氯离子离去基团实现催化不对称诱导。

  DOI：

  10.1021/acs.orglett.4c00358
• 作为试剂：
  描述：

  4-(1-methyl-1-propyloxy)-phenol 、 甲基(2-chloroethyl)氨基甲酸酯 、 potassium carbonate 、 水 在 乙醚 、 水 、 calcium sulfate 、 甲基(2-chloroethyl)氨基甲酸酯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以gives methyl N-{2-[4-(1-methylpropoxy)phenoxy]ethyl}carbamate的产率得到methyl N-{2-[4-(1-methylpropoxy)phenoxy]ethyl}carbamate
  参考文献：
  名称：

  Carbamic and carbamothioic acid esters as pesticides

  摘要：

  某些新型的氨基甲酸酯衍生物及其在害虫控制方面的应用。

  公开号：

  US04697033A1

文献信息

• Diaryl ethers
  申请人：Hoffmann-La Roche Inc.

  公开号：US04792616A1

  公开（公告）日：1988-12-20

  Novel diaryl ethers of the formula ##STR1## wherein A is CR.sup.3 or N and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, n and R.sup.6 are as defined hereinafter, processes for their preparation, herbicidal compositions which contain these compounds as the active ingredient as well as the use of these compounds or compositions for the control of weeds is disclosed.

  公开了式子##STR1##中A为CR.sup.3或N，R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、n和R.sup.6如下所定义的新型二芳醚，以及它们的制备方法、含有这些化合物作为活性成分的除草剂组合物，以及利用这些化合物或组合物控制杂草的用途。
• Ether compounds, their use, and intermediates for use in their production
  申请人：Sumitomo Chemical Company, Limited

  公开号：US05684022A1

  公开（公告）日：1997-11-04

  There are disclosed novel ether compounds of the general formula: ##STR1## wherein R.sup.1 is halogen; A is a group of the general formula Q-1: --CH(R.sup.2)--(CH.sub.2).sub.m --CH (R.sup.3)--N(R.sup.4)--C(.dbd.Y)--X--R.sup.5, or the like; E is a group of the general formula: ##STR2## and l is an integer of 0 to 2; harmful-organism controlling agents containing them as active ingredients, and intermediates for use in their production.

  披露了一种新型醚类化合物，其一般式如下：##STR1## 其中R.sup.1为卤素；A为一般式Q-1的基团：--CH(R.sup.2)--(CH.sub.2).sub.m --CH (R.sup.3)--N(R.sup.4)--C(.dbd.Y)--X--R.sup.5，或类似物；E为一般式：##STR2## l为0至2的整数；包含它们作为活性成分的有害生物控制剂，以及用于生产它们的中间体。
• Acylated carbamates and use as insecticides
  申请人：Ciba-Geigy Corporation

  公开号：US05114968A1

  公开（公告）日：1992-05-19

  Novel N-acylated 2-[4-(4-fluorophenoxy)phenoxy]ethylcarmabates of formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.4 alkenyl or C.sub.3 -C.sub.4 alkynyl, R.sub.2 is C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, --CO--R.sub.5 or --NR.sub.6 R.sub.7, R.sub.3 and R.sub.4 are each independently of the other hydrogen or methyl, R.sub.5 is C.sub.1 -C.sub.8 alkoxy or --NR.sub.8 R.sub.9, R.sub.6 is C.sub.1 -C.sub.4 alkyl, R.sub.7 is C.sub.1 -C.sub.4 alkyl or R.sub.6 and R.sub.7 together are a C.sub.4 -C.sub.6 alkylene chain which may be interrupted by oxygen, sulfur or --NCH.sub.3 --, R.sub.8 is hydrogen or C.sub.1 -C.sub.4 alkyl, and R.sub.9 is hydrogen, C.sub.1 -C.sub.4 alkyl, benzyl, phenyl or phenyl which is substituted by halogen or methyl, or R.sub.8 and R.sub.9 together are a C.sub.4 -C.sub.6 alkylene chain which may be interrupted by oxygen, sulfur or --NCH.sub.3 --.

  化学式为I的新型N-酰化的2-[4-(4-氟苯氧)苯氧基]乙基卡马巴特，其中R1为C1-C8烷基，C3-C4烯基或C3-C4炔基，R2为C1-C8烷基，C1-C8烷氧基，-CO-R5或-NR6R7，R3和R4各自独立地是氢或甲基，R5为C1-C8烷氧基或-NR8R9，R6为C1-C4烷基，R7为C1-C4烷基或R6和R7一起是一个C4-C6的亚烷基链，可以被氧、硫或-NCH3-中断，R8为氢或C1-C4烷基，R9为氢、C1-C4烷基、苄基、苯基或被卤素或甲基取代的苯基，或R8和R9一起是一个C4-C6的亚烷基链，可以被氧、硫或-NCH3-中断。
• Bisacylethylamines
  申请人：Ciba-Geigy Corporation

  公开号：US05166153A1

  公开（公告）日：1992-11-24

  Novel N-acylated 2-[4-(halophenoxy)-phenoxy]-ethylcarbamic acid esters of formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 alkyl or C.sub.3 -C.sub.5 alkenyl, R.sub.2 is C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, --CO--R.sub.7 or --NR.sub.8 R.sub.9, R.sub.3 and R.sub.4 independently of one another are hydrogen or methyl, R.sub.5 is chlorine or fluorine, R.sub.6 is either the same substituent as R.sub.5 or is hydrogen, R.sub.7 is C.sub.1 -C.sub.8 alkoxy or --NR.sub.10 R.sub.11, R.sub.8 is C.sub.1 -C.sub.4 alkyl, R.sub.9 is C.sub.1 -C.sub.4 alkyl or R.sub.8 and R.sub.9 together form a C.sub.4 -C.sub.6 alkylene chain which may be interrupted by oxygen, sulfur or --NCH.sub.3 --, R.sub.10 is hydrogen or C.sub.1 -C.sub.4 alkyl and R.sub.11 is hydrogen or C.sub.1 -C.sub.4 alkyl, benzyl, phenyl, or phenyl substituted by halogen or by methyl, or R.sub.10 and R.sub.11 together form a C.sub.4 -C.sub.6 alkylene chain which may be interrupted by oxygen, sulfur or --NCH.sub.3 --; their preparation, their use in pest control, and pesticidal compositions that contain those carbamic acid esters as active ingredient are disclosed.

  公式I中的新型N-酰化2-[4-(卤代)苯氧基]-苯氧基-乙酸酯，其中R.sub.1为C.sub.1-C.sub.8烷基或C.sub.3-C.sub.5烯基，R.sub.2为C.sub.1-C.sub.8烷基、C.sub.1-C.sub.8烷氧基、--CO--R.sub.7或--NR.sub.8 R.sub.9，R.sub.3和R.sub.4独立地为氢或甲基，R.sub.5为氯或氟，R.sub.6为与R.sub.5相同的取代基或氢，R.sub.7为C.sub.1-C.sub.8烷氧基或--NR.sub.10 R.sub.11，R.sub.8为C.sub.1-C.sub.4烷基，R.sub.9为C.sub.1-C.sub.4烷基或R.sub.8和R.sub.9共同形成的C.sub.4-C.sub.6烷基链，该链可以被氧、硫或--NCH.sub.3--所中断，R.sub.10为氢或C.sub.1-C.sub.4烷基，R.sub.11为氢或C.sub.1-C.sub.4烷基、苄基、苯基或被卤素或甲基取代的苯基，或R.sub.10和R.sub.11共同形成的C.sub.4-C.sub.6烷基链，该链可以被氧、硫或--NCH.sub.3--所中断；揭示了它们的制备方法、它们在害虫控制中的应用以及包含这些乙酸酯作为活性成分的杀虫剂组合物。
• Sulfenylated carbamic esters and their use in pesticides
  申请人：Ciba-Geigy Corporation

  公开号：US05192803A1

  公开（公告）日：1993-03-09

  Novel substituted 2-phenoxyphenoxyethylcarbamic esters of the formula I ##STR1## where R.sub.1 is C.sub.1 -C.sub.4 alkyl or C.sub.3 -C.sub.4 alkenyl, R.sub.2 is C.sub.1 -C.sub.4 alkyl or a radical of the formula ##STR2## --C(CH.sub.3).sub.2 --CN or --N(R.sub.9)--COO--C.sub.1 -C.sub.4 alkyl, R.sub.3 and R.sub.4 independently of one another are hydrogen or methyl, R.sub.5 is fluorine or chlorine, R.sub.6 is either identical to the substituents given in the case of R.sub.5 or is hydrogen, R.sub.7 and R.sub.8 independently of one another are hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or nitro, R.sub.9 is C.sub.1 -C.sub.4 alkyl and n is zero, one or two, their preparation, their use in pest control, and pesticides containing these carbamic esters as active substance, are described. The preferred field of application is the control of pests on animals and plants, in partcular of eggs and larvae of phytophagous harmful insects and harmful mites.

  本发明涉及式I的新型取代的2-苯氧基苯氧基乙基氨基甲酸酯，其中R.sub.1是C.sub.1-C.sub.4烷基或C.sub.3-C.sub.4烯基，R.sub.2是C.sub.1-C.sub.4烷基或公式的基团：--C(CH.sub.3).sub.2--CN或--N(R.sub.9)--COO--C.sub.1-C.sub.4烷基，R.sub.3和R.sub.4分别独立地是氢或甲基，R.sub.5是氟或氯，R.sub.6要么与R.sub.5中给出的取代基相同，要么是氢，R.sub.7和R.sub.8独立地是氢，卤素，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4烷氧基或硝基，R.sub.9是C.sub.1-C.sub.4烷基，n为零，一或二。本发明还涉及这些氨基甲酸酯的制备方法，它们在害虫控制中的使用以及含有这些氨基甲酸酯作为活性成分的杀虫剂。首选的应用领域是在动植物上控制害虫，特别是植食性有害昆虫和有害螨的卵和幼虫。