N-十二烷基甘氨酸 | 2274-80-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-十二烷基甘氨酸
• 英文名称: N-dodecylglycine
• 英文别名: 2-(Dodecylazaniumyl)acetate
• CAS: 2274-80-8
• 化学式: C₁₄H₂₉NO₂
• 分子量: 243.39
• InChiKey: LNPHVNNRZGCOBK-UHFFFAOYSA-N

物化性质

• 熔点：
  117.5 °C
• 沸点：
  356.4±25.0 °C(Predicted)
• 密度：
  0.925±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

反应信息

• 作为反应物：
  描述：

  N-十二烷基甘氨酸 、 4’-甲基-2,2’-联吡啶-4-甲醛 、 足球烯 以 甲苯 为溶剂， 反应 15.0h， 以55%的产率得到
  参考文献：
  名称：

  Design and Synthesis of Bipyridine Platinum(II) Bisalkynyl Fullerene Donor–Chromophore–Acceptor Triads with Ultrafast Charge Separation

  摘要：

  Donor chromophore acceptor triads, (PTZ)(2)-Pt(bpy)C-60 and ((1)BuPTZ)(2)-Pt(bpy)-C-60, along with their model compound, (Ph)(2)-Pt(bpy)-C-60, have been synthesized and characterized; their photophysical and electrochemical properties have been studied, and the origin of the absorption and emission properties has been supported by computational studies. The photoinduced electron transfer reactions have been investigated using the femtosecond and nanosecond transient absorption spectroscopy. In dichloromethane, (Ph)(2)-Pt(bpy)-C-60 shows ultrafast triplet triplet energy transfer from the 3MLCT/LLCT excited state within 4 ps to give the 3C60* state, while in (PTZ)(2)Pt(bpy)-C-60 and ((1)BuPTZ)(2)-Pt(bpy)-C-60, charge-separated state forms within 400 fs from the 3MLCT/LLCT excited state with efficiency of over 0.90, and the total efficiency with the contribution of C-3(60)* is estimated to be 0.99. Although the forward electron transfer reactions are very rapid, the charge-separated state recombines to the singlet ground state at a time of hundreds of nanoseconds because of the difference in spin multiplicity between the charge-separated state and the ground state.

  DOI：

  10.1021/ja5040073
• 作为产物：
  描述：

  2-(十二烷基氨基)乙腈 在 硫酸 作用下， 反应 3.0h， 以53.5%的产率得到N-十二烷基甘氨酸
  参考文献：
  名称：

  高级烷基胺类化合物的合成及抗菌活性

  摘要：

  最近，人们对高级聚烷基胺 (I) 与卤代羧酸 tII) 反应的产物给予了极大的关注，在其他国家以 TEGO 消毒剂的名义已知。它们对细菌的营养形式 [i, 2]、结核分枝杆菌 [3, 4]、真菌 [5] 和某些形式的病毒 [6, 7] 具有高杀菌活性。这些制剂的去污性能不亚于阴离子表面活性剂~SAA)，而且非常重要的是，它们对温血动物只有轻微的毒性[8]。

  DOI：

  10.1007/bf00759466

文献信息

• Sun protection compositions comprising semi-crystalline polymers and hollow latex particles
  申请人：Candau Didier

  公开号：US20090041691A1

  公开（公告）日：2009-02-12

  Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30° C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.

  具有增强SPF的适用于化妆品/皮肤科的防紫外线保护组合物至少包含一种有机紫外线过滤剂和/或至少一种无机过滤剂，此类组合物还至少包含以下成分（A）和（B）： A）半结晶聚合物，室温下为固体，熔点大于或等于30°C，包含a）聚合骨架和b）至少一种可结晶有机侧链和/或作为该聚合物骨架一部分的可结晶有机块，该聚合物具有大于或等于1,000的数均分子质量Mn，以及 B）中空乳胶颗粒，粒径范围为150至380纳米，配制成适用于局部使用的、生理上可接受的介质。
• COSMETIC TREATMENT METHOD USING A COMPOUND THAT CAN BE CONDENSED IN SITU AND A UV-RADIATION-FILTERING AGENT
  申请人：Samain Henri

  公开号：US20120328542A1

  公开（公告）日：2012-12-27

  The present invention relates to a method for the cosmetic treatment of the skin, comprising the application, to the skin: of a compound or group of compounds A capable of condensing in situ and exhibiting at least one reactive functional group F A which is free after condensation; and of a screening agent C which screens out UV radiation, comprising a reactive functional group F C capable of forming a covalent bond or a physical (ionic, hydrogen) bond by reaction with the functional group F A .

  本发明涉及一种用于皮肤美容治疗的方法，包括将以下物质应用于皮肤： 一种或一组化合物A，能够在原位缩合并具有至少一个反应性功能基团F A ，在缩合后是自由的；以及 一种用于屏蔽紫外线辐射的筛选剂C，包括一个具有反应性功能基团F C 的物质，能够通过与功能基团F A 的反应形成共价键或物理（离子、氢）键。
• [EN] ORGANOSILOXANE COMPOSITION HAVING HIGH REFRACTIVE INDEX AND APPLICATIONS CONTAINING THE SAME<br/>[FR] COMPOSITION D'ORGANOSILOXANE AYANT UN INDICE DE RÉFRACTION ÉLEVÉ ET APPLICATIONS LA CONTENANT
  申请人：MOMENTIVE PERFORMANCE MAT JP

  公开号：WO2016089817A1

  公开（公告）日：2016-06-09

  The invention is directed to a silicone compound of the general formula (I) and a personal care composition comprising the silicone compound (I) as described herein, and to personal care applications containing the same and processes of making the silicone compound.

  这项发明涉及一种通式（I）所示的硅氧烷化合物，以及包括所述硅氧烷化合物（I）的个人护理组合物，以及含有该硅氧烷化合物的个人护理用途和制备该硅氧烷化合物的方法。
• Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor
  申请人：Lucet-Levannier Karine

  公开号：US20100086502A1

  公开（公告）日：2010-04-08

  Cosmetic/sunscreen compositions contain a combination of at least one dibenzoylmethane sunscreen compound and a photostabilizing amount of at least one dithiolane compound of formula (I) below:

  化妆品/防晒霜组合物含有至少一种二苯甲酮类防晒剂化合物和至少一种式（I）所示的二硫杂环化合物的光稳定量。
• [EN] N-ALKYLATED AMINO ACIDS AND OLIGOPEPTIDES, USES THEREOF AND METHODS FOR PROVIDING THEM.<br/>[FR] ACIDES AMINÉS N-ALKYLÉS ET OLIGOPEPTIDES, LEURS UTILISATIONS ET LEURS PROCÉDÉS DE PRODUCTION
  申请人：UNIV GRONINGEN

  公开号：WO2018178397A1

  公开（公告）日：2018-10-04

  The invention relates to the synthesis of amphiphilic amino acid derivatives, in particular to a method for the N-alkylation of an unprotected amino acid or the N-terminus of an oligopeptide substrate, comprising reacting said unprotected amino acid or oligopeptide substrate with an alcohol, e.g. a fatty alcohol, in the presence of a homogeneous transition metal catalyst.

  该发明涉及两性氨基酸衍生物的合成，特别涉及一种用于对未保护的氨基酸或寡肽底物的N-烷基化的方法，包括将所述未保护的氨基酸或寡肽底物与醇（例如脂肪醇）在均相过渡金属催化剂的存在下反应。