lauryl Ν,Ν-dimethylaminoacetamide | 16577-82-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: lauryl Ν,Ν-dimethylaminoacetamide
• 英文别名: 2-(N,N-dimethyl)-N′-dodecylethanamide；N,N-dimethyl-glycine dodecylamide；N,N-Dimethyl-glycin-dodecylamid；Dimethylamino-essigsaeure-dodecylamid；2-dimethylamino-N-dodecyl-acetamide；N-Dodecyl-N~2~,N~2~-dimethylglycinamide；2-(dimethylamino)-N-dodecylacetamide
• CAS: 16577-82-5
• 化学式: C₁₆H₃₄N₂O
• 分子量: 270.459
• InChiKey: FJJJJDTVUJYUAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-丙烷磺内酯 、 lauryl Ν,Ν-dimethylaminoacetamide 反应 5.0h， 以89.7%的产率得到3-((2-laurylamino-2-oxoethyl)dimethylammonio)propanesulfonate
  参考文献：
  名称：

  [EN] AMPHOTERIC BETAINE COMPOUNDS
  [FR] COMPOSÉS DE BÉTAÏNE AMPHOTÈRE

  摘要：

  披露了一系列含有季铵氮基团、共价结合的对离子和酯或酰胺基团的两性化合物。这些两性化合物可以通过化酶绿色过程有利地制备，并表现出良好的表面活性剂性能。

  公开号：

  WO2017048528A1
• 作为产物：
  描述：

  十二烷基伯胺 在 乙醇 、 二甲胺 作用下， 生成 lauryl Ν,Ν-dimethylaminoacetamide
  参考文献：
  名称：

  Quaternary ammonium compounds

  摘要：

  公开号：

  US02317999A1

文献信息

• Hair Growth Regulating Agent
  申请人：Suzuki Yasuto

  公开号：US20110130456A1

  公开（公告）日：2011-06-02

  A hair growth regulating agent containing, as an active ingredient, a compound represented by the following formula (I): [wherein R1 represents a substituted or unsubstituted, linear or branched C2 to C25 alkyl group; a group represented by the following formula (II): (wherein R1′ represents a substituted or unsubstituted, linear or branched C2 to C20 alkylene group, or —(CH2)n-O—(CH2)m}o-O—(CH2)p- in which each of n, m, o, and p is an integer from 1 to 6; X′ represents —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO—, or —O—; Y′ represents a substituted or unsubstituted C1 to C4 alkylene group; R2′ represents a hydrogen atom or a C1 to C4 alkyl group; R3′ represents a C1 to C4 alkyl group; and when R2′ and R3′ each represent a C1 to C4 alkyl group, the two alkyl groups may be identical to or different from each other); or a group represented by the following formula (III): (wherein R1′, X′, and Y′ have the same meanings as defined above; R4′, R5′, and R6′, which may be identical to or different from one another, each represent a C1 to C4 alkyl group; and A′- represents a counter ion); X represents —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO—, or —O—; Y represents a substituted or unsubstituted C1 to C4 alkylene group; R2 represents a hydrogen atom or a C1 to C4 alkyl group; R3 represents a C1 to C4 alkyl group; and when R2 and R3 each represent a C1 to C4 alkyl group, the two alkyl groups may be identical to or different from each other] or a salt of the compound; and/or a quaternary ammonium salt represented by the following formula (IV): (wherein R1, X, and Y have the same meanings as defined above; R4, R5, and R6, which may be identical to or different from one another, each represent a C1 to C4 alkyl group; and A- represents a counter ion).

  一种含有以下式（I）所代表的化合物作为活性成分的头发生长调节剂：[其中R1代表取代或未取代的直链或支链C2至C25烷基团；由以下式（II）表示的基团：（其中R1'代表取代或未取代的直链或支链C2至C20烷基烯基团，或者—（CH2）n-O—（CH2）m}o-O—（CH2）p-，其中n，m，o和p中的每个都是1至6的整数；X'代表—CO—NH—，—O—CO—O—，—NH—CO—，—CO—O—，—O—CO—或—O—；Y'代表取代或未取代的C1至C4烷基烯基团；R2'代表氢原子或C1至C4烷基团；R3'代表C1至C4烷基团；当R2'和R3'各自代表C1至C4烷基团时，这两个烷基团可以相同或不同）；或由以下式（III）表示的基团：（其中R1'，X'和Y'的含义与上述定义相同；R4'，R5'和R6'，可以相同也可以不同，各代表C1至C4烷基团；A'-代表一个对离子）；X代表—CO—NH—，—O—CO—O—，—NH—CO—，—CO—O—，—O—CO—或—O—；Y代表取代或未取代的C1至C4烷基烯基团；R2代表氢原子或C1至C4烷基团；R3代表C1至C4烷基团；当R2和R3各自代表C1至C4烷基团时，这两个烷基团可以相同或不同]或该化合物的盐；和/或由以下式（IV）所代表的季铵盐：（其中R1，X和Y的含义与上述定义相同；R4，R5和R6，可以相同也可以不同，各代表C1至C4烷基团；A-代表一个对离子）。
• Composition for External Application to Skin
  申请人：Suzuki Yasuto

  公开号：US20100273875A1

  公开（公告）日：2010-10-28

  A composition for external application to skin, containing a compound represented by formula (I) or a salt thereof, and/or a quaternary ammonium salt represented by formula (II): wherein R 1 is a substituted or unsubstituted, linear or branched chain alkyl group having 2 to 25 carbon atoms; X is —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO— or —O—; Y is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; R 2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 3 is an alkyl group having 1 to 4 carbon atoms; R 2 and R 3 are the same as or different from each other; R 4 , R 5 and R 6 , which may the same as or different from each other, each are an alkyl group having 1 to 4 carbon atoms; and A − is a counter ion.

  一种用于外用于皮肤的组合物，含有由式（I）或其盐所代表的化合物和/或由式（II）所代表的季铵盐：其中，R1是具有2到25个碳原子的取代或未取代的线性或支链烷基；X是-CO-NH-，-O-CO-O-，-NH-CO-，-CO-O-，-O-CO-或-O-；Y是具有1到4个碳原子的取代或未取代的亚烷基基团；R2是氢原子或具有1到4个碳原子的烷基基团；R3是具有1到4个碳原子的烷基基团；R2和R3相同或不同；R4、R5和R6，它们可以相同也可以不同，每个都是具有1到4个碳原子的烷基基团；A-是一个反离子。
• COMPOSITION FOR EXTERNAL APPLICATION TO SKIN
  申请人：Kao Corporation

  公开号：EP2221040A1

  公开（公告）日：2010-08-25

  A composition for external application to skin, containing a compound represented by formula (I) or a salt thereof, and/or a quaternary ammonium salt represented by formula (II): wherein R1 is a substituted or unsubstituted, linear or branched chain alkyl group having 2 to 25 carbon atoms; X is -CO-NH-, -O-CO-O-, -NH-CO-, - CO-O-, -O-CO- or -O-; Y is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R3 is an alkyl group having 1 to 4 carbon atoms; R2 and R3 are the same as or different from each other; R4, R5 and R6, which may the same as or different from each other, each are an alkyl group having 1 to 4 carbon atoms; and A- is a counter ion.

  一种用于皮肤外用的组合物，含有式 (I) 所代表的化合物或其盐，和/或式 (II) 所代表的季铵盐： 其中 R1 是具有 2 至 25 个碳原子的取代或未取代的直链或支链烷基；X 是-CO-NH-、-O-CO-O-、-NH-CO-、-CO-O-、-O-CO-或-O-；Y 是具有 1 至 4 个碳原子的取代或未取代的亚烷基；R2 是氢原子或具有 1 至 4 个碳原子的烷基；R3 是具有 1 至 4 个碳原子的烷基；R2 和 R3 彼此相同或不同；R4、R5 和 R6 可能彼此相同或不同，各自是具有 1 至 4 个碳原子的烷基；以及 A- 是反离子。
• Amphoteric compounds
  申请人：Eastman Chemical Company

  公开号：US11414380B2

  公开（公告）日：2022-08-16

  Disclosed are a variety of amphoteric compounds containing a quaternary nitrogen group, a covalently bound counterion, and an ester or amide group. These amphoteric compounds can be advantageously prepared via a chemoenzymatic green process, and exhibit good surfactant properties.

  本发明公开了多种两性化合物，这些化合物含有一个季氮基、一个共价结合的反离子和一个酯或酰胺基。这些两性化合物可通过化学酶绿色工艺制备，具有良好的表面活性剂特性。
• Membrane Active Small Molecules Show Selective Broad Spectrum Antibacterial Activity with No Detectable Resistance and Eradicate Biofilms
  作者：Jiaul Hoque、Mohini M. Konai、Spandhana Gonuguntla、Goutham B. Manjunath、Sandip Samaddar、Venkateswarlu Yarlagadda、Jayanta Haldar

  DOI：10.1021/acs.jmedchem.5b00443

  日期：2015.7.23

  Treating bacterial biofilms With conventional antibiotics is limited due to ineffectiveness of the drugs and higher propensity to develop bacterial resistance. Development of new classes of antibacterial therapeutics with alternative mechanisms of action has become imperative. Herein, we report the design, synthesis, and biological evaluations of novel membrane,active small molecules featuring two positive charges, four nonpeptidic,amide groups, and variable hydro, phobic/hydrophilic (amphiphilic) character. The biocides synthesized via a facile methodology not only displayed good antibacterial activity against wild-type bacteria but also showed high activity against various drug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), and beta-lactam-resistant Klebsiella pneumoniae. Further, these biocides not only inhibited the formation of biofilms but also disrupted the established S. aureus and E. coli biofilms. The membrane-active biocides hindered the propensity to develop bacterial resistance. Moreover; the biocides showed negligible toxicity against mammalian cells and thus bear potential to be used as therapeutic agents.