己-5-烯-1,2,3-三醇 | 89534-51-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 己-5-烯-1,2,3-三醇
• 英文名称: [R-(R*,R*)]-5-Hexene-1,2,3-triol
• 英文别名: 5-hexene-1,2,3-triol；(+)-1-allylglycerol；(R)(+)-1-allylglycerol；hex-5-ene-1,2,3-triol
• CAS: 89534-51-0
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: LOUUJHLYXOLVKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  己-5-烯-1,2,3-三醇 生成 opt.-inakt.-1,2,3-Triacetoxy-hexen-(5)
  参考文献：
  名称：

  UNEYAMA, KENJI;KAMAKI, NOBUVOSHI;MORIYA, AKIHIKO;TORII, SIGERU, J. ORG. CHEM., 1985, 50, N 25, 5396-5399

  摘要：

  DOI：
• 作为产物：
  描述：

  (S)-4-((allyloxy)methyl)-2,2-dimethyl-1,3-dioxolane 在 盐酸 作用下， 以 丙酮 为溶剂， 以93%的产率得到己-5-烯-1,2,3-三醇
  参考文献：
  名称：

  Chiral crown ethers

  摘要：

  本文介绍了光学活性异构体双(12-冠-4-甲基)二烷基丙二酸酯的合成和使用作为钠特异性离子载体。同时还描述了光学活性异构体羟甲基12-冠-4的合成，该化合物在合成离子载体时具有重要作用。

  公开号：

  US05047563A1

文献信息

• Selective allylation of carbonyl compounds in aqueous media
  作者：Cathy Einhorn、Jean-Louis Luche

  DOI：10.1016/0022-328x(87)85005-2

  日期：1987.3

  The use of aqueous neutral media leads to excellent yields of homoallylic alcohols from reaction sof allyl halides with carbonyl compounds in the presence of tin or zinc. The stereochemical course and range of application of this reaction have been investigated.

  在锡或锌的存在下，使用水性中性介质可导致烯丙基卤化物与羰基化合物的反应，使烯丙基卤化物与羰基化合物反应，均一醇的收率极高。已经研究了该反应的立体化学过程和应用范围。
• Tsuji–Wacker-Type Oxidation beyond Methyl Ketones: Reacting Unprotected Carbohydrate-Based Terminal Olefins through the “Uemura System” to Hemiketals and α,β-Unsaturated Diketones
  作者：Patrik A. Runeberg、Patrik C. Eklund

  DOI：10.1021/acs.orglett.9b02134

  日期：2019.10.18

  Aerobic Pd(AcO)2/pyridine-catalyzed oxidation of unprotected carbohydrate-based terminal alkenes was studied. In accordance with previous reports, the initial reaction step gave methyl ketones. However, our substrates partially gave subsequent α,β-water elimination and alcohol oxidation to α,β-unsaturated 2,5-diketones. Upon increasing the pressure of O2, the reaction was shifted toward formation of

  研究了好氧的Pd（AcO）2 /吡啶催化的未保护的基于碳水化合物的末端烯烃的氧化。根据先前的报道，最初的反应步骤得到了甲基酮。然而，我们的底物部分地随后使α，β-水消除和醇氧化成α，β-不饱和的2，5-二酮。随着O 2压力的增加，反应转向形成α，β-环氧-2-酮。反应是立体选择性的，并放弃了定量转化。然而，由于产物混合物的复杂性，分离的产率明显较低。
• DETERGENT COMPOSITION COMPRISING A CARBINOL FUNCTIONAL TRISILOXANE
  申请人：Dow Silicones Corporation

  公开号：US20190112549A1

  公开（公告）日：2019-04-18

  A detergent composition comprises a trisiloxane having at least one carbinol functional group. The trisiloxane comprises the reaction product of (A) an initial trisiloxane and (B) an organic compound. Component (A) has a pendant silicon-bonded functional group selected from a hydrogen atom, an epoxy-containing group, an ethylenically unsaturated group, and an amine group. Typically, component (A) is free of certain terminal silicon-bonded functional groups and is free of polyoxyalkylene groups. Component (B) has a functional group reactive with the pendant silicon-bonded functional group of component (A), and has at least one hydroxyl functional group. The trisiloxane may be of the following general formula (I): (R 1 3 SiO 1/2 )(R 1 R 3 SiO 2/2 )(R 1 3 SiO 1/2 ) (I). In formula (I), each R 1 is an independently selected hydrocarbyl group. R 3 may be selected from the groups (i) to (x) described herein, each of the groups having at least one carbinol group. Typically, the trisiloxane has 1-6 carbinol groups.

  一种洗涤剂组合物包括至少一个羟基官能团的三硅氧烷。该三硅氧烷包括（A）初始三硅氧烷和（B）有机化合物的反应产物。组分（A）具有从氢原子、含环氧基团、乙烯不饱和基团和胺基团中选择的侧链硅键官能团。通常，组分（A）不含特定的末端硅键官能团，也不含聚氧烷基团。组分（B）具��与组分（A）的侧链硅键官能团反应的官能团，并且具有至少一个羟基官能团。该三硅氧烷可以是以下一般式（I）的：（R13SiO1/2）（R1R3SiO2/2）（R13SiO1/2）（I）。在式（I）中，每个R1是独立选择的烃基团。R3可以从此处描述的（i）到（x）组中选择，每个组至少有一个羟基团。通常，该三硅氧烷具有1-6个羟基官能团。
• SILICONE CONTAINING MONOMERS WITH HYDROPHILIC END GROUPS
  申请人：DSM IP ASSETS B.V.

  公开号：US20170088564A1

  公开（公告）日：2017-03-30

  Silicone containing reactive monomers with hydrophilic end-groups of formula I useful in the manufacture of biocompatible medical devices are disclosed, wherein R 1 is H or CH 3 , a is 0 or 1, p is an integer from 1 to 6, q is an integer from 1 to 3 and for each q, the end groups R 51 , R 52 , R 53 are independently an alkyl, alkyl ether, urethane, trimethylsiloxy group, or a substituted or non-substituted aromatic group and at least one of them has a hydrophilic group Z attached wherein said hydrophilic group Z is selected from the group of poly(ethylene glycol), poly(propylene glycol), poly(ethyl oxazoline), poly(methyl oxazoline), hyaluronic acid, or combinations thereof, preferably to the terminal end of R 51 , R 52 , R 53 , X is O or NR 54 , where R 54 is H or a monovalent alkyl group with 1 to 4 carbons, n is an integer from 1 to 100, R 2 and R 3 is independently an alkyl, alkyl ether, trimethylsiloxy group, or a substituted or non-substituted aromatic group, preferred R 2 and R 3 include methyl, ethyl, trimethylsiloxy and phenyl, L is a divalent linker comprising substituted and unsubstituted alkylene groups having 1-14 carbon atoms, which may be straight or branched, substituted and unsubstituted alkoxy groups having 2-12 carbons, polyethers, oxazolines, substituted and unsubstituted heterocyclic groups. The reactive monomers combine oxygen permeable silicone components with hydrophilic terminal groups capable of reaching to the device-biologic interface thus providing bulk and surface characteristics useful in the manufacture of medical devices, particularly ophthalmic devices.

  公开了一种具有式I的含有反应单体的硅含有亲水端基，用于制造生物相容性医疗器械，其中R1为H或CH3，a为0或1，p为1到6的整数，q为1到3的整数，对于每个q，端基R51、R52、R53独立地为烷基、烷基醚、脲、三甲基硅氧基团或取代或未取代的芳香基，并且其中至少一个具有连接的亲水基团Z，其中所述的亲水基团Z选自聚乙二醇、聚丙烯醇、聚乙基噁唑烷、聚甲基噁唑烷、透明质酸或其组合的群组，优选地连接到R51、R52、R53的末端，X为O或NR54，其中R54为H或具有1到4个碳的一价烷基，n为1到100的整数，R2和R3独立地为烷基、烷基醚、三甲基硅氧基团或取代或未取代的芳香基，优选的R2和R3包括甲基、乙基、三甲基硅氧基和苯基，L为二价连接剂，包括取代和未取代的具有1-14个碳原子的烷基烃基，可能是直链或支链，取代和未取代的具有2-12个碳原子的烷氧基团，聚醚，噁唑烷，取代和未取代的杂环基团。这些反应单体将氧透过性硅组分与具有能够到达器械生物界面的亲水末端基团结合，从而提供有利于制造医疗器械的体积和表面特性，特别是眼科器械。
• Grignard-type allylation of carbonyl compounds in methanol by the electrochemically recycled allyltin reagent.
  作者：Kenji Uneyama、Hiroyuki Matsuda、Sigeru Torii

  DOI：10.1016/s0040-4039(01)81748-2

  日期：——

  An electrochemical allylation of aldehydes and ketones in methanol was achieved by the electroreductive regeneration of diallyltin reagent in the presence of a catalytic amount of tin, affording the corresponding homoallyl alcohols in 72 – 91% yields.

  在催化量的锡存在下，通过对二烯丙基化试剂进行电还原再生，实现了甲醇中醛和酮的电化学烯丙基化，从而以72 – 91％的产率提供了相应的均烯丙基醇。