2-benzoyl-4-(2-methylbenzoyl)-5-phenyl-1-o-tolylpentane-1,5-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-benzoyl-4-(2-methylbenzoyl)-5-phenyl-1-o-tolylpentane-1,5-dione
• 英文别名: 2,4-Dibenzoyl-1,5-bis(2-methylphenyl)pentane-1,5-dione；2,4-dibenzoyl-1,5-bis(2-methylphenyl)pentane-1,5-dione
• 化学式: C₃₃H₂₈O₄
• 分子量: 488.583
• InChiKey: MYDFRBOURDMFBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四甲基乙二胺 、 1-(2-甲基苯基)-3-苯基丙烷-1,3-二酮 在 dipotassium peroxodisulfate 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以86%的产率得到2-benzoyl-4-(2-methylbenzoyl)-5-phenyl-1-o-tolylpentane-1,5-dione
  参考文献：
  名称：

  Oxidative C(Sp3)–H activation and C–N cleavage of N-methyl amines under transition-metal-free condition for synthesis of methylene-bridged bis-1,3-diketones

  摘要：

  A transition-metal-free oxidative methylenation reaction was developed. Methylene-bridged bis-1,3-dicarbonyl compounds were synthesized by oxidative C(Sp(3))-H activation and C-N cleavage of N-methyl amines. This novel reaction avoids the use of transition metal catalyst. Furthermore, the reaction are very mild and operational convenient. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.033

文献信息

• Acid-promoted oxidative methylenation of 1,3-dicarbonyl compounds with DMSO: application to the three-component synthesis of Hantzsch-type pyridines
  作者：LuLu Xue、Guolin Cheng、Ruifeng Zhu、Xiuling Cui

  DOI：10.1039/c7ra07442e

  日期：——

  A highly convergent one-pot synthesis of Hantzsch-type pyridines has been developed based on a three-component annulation of 1,3-dicarbonyl compounds, DMSO, and ammonium salt. A transition-metal-free oxidative methylenation reaction/Hantzsch pyridine synthesis cascade reaction was involved in this process. This intermolecular annulation reaction proceeds under mild reaction conditions, wherein DMSO

  基于1,3-二羰基化合物，DMSO和铵盐的三组分环化反应，已开发出高度收敛的一锅法合成Hantzsch型吡啶。该过程涉及无过渡金属的氧化亚甲基化反应/汉茨吡啶合成级联反应。该分子间环化反应在温和的反应条件下进行，其中DMSO用作溶剂，碳源和氧化剂。以高收率制备了一系列多取代的吡啶和亚甲基桥联的双-1,3-二羰基化合物。
• Oxidative C(Sp3)–H activation and C–N cleavage of N-methyl amines under transition-metal-free condition for synthesis of methylene-bridged bis-1,3-diketones
  作者：Xiaohu Wang、Yi Wang、Yu Yuan、Chun-Hui Xing

  DOI：10.1016/j.tet.2014.01.033

  日期：2014.3

  A transition-metal-free oxidative methylenation reaction was developed. Methylene-bridged bis-1,3-dicarbonyl compounds were synthesized by oxidative C(Sp(3))-H activation and C-N cleavage of N-methyl amines. This novel reaction avoids the use of transition metal catalyst. Furthermore, the reaction are very mild and operational convenient. (C) 2014 Elsevier Ltd. All rights reserved.