2-benzoyl-4-(3-chlorobenzoyl)-1-(3-chlorophenyl)-5-phenylpentane-1,5-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-benzoyl-4-(3-chlorobenzoyl)-1-(3-chlorophenyl)-5-phenylpentane-1,5-dione
• 英文别名: 2,4-dibenzoyl-1,5-bis(3-chlorophenyl)pentane-1,5-dione；2,4-Dibenzoyl-1,5-bis(3-chlorophenyl)pentane-1,5-dione
• 化学式: C₃₁H₂₂Cl₂O₄
• 分子量: 529.419
• InChiKey: QHPCQLHWZMZUOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四甲基乙二胺 、 1-(3'-氯苯基)-3-苯基丙烷-1,3-二酮 在 dipotassium peroxodisulfate 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以75%的产率得到2-benzoyl-4-(3-chlorobenzoyl)-1-(3-chlorophenyl)-5-phenylpentane-1,5-dione
  参考文献：
  名称：

  Oxidative C(Sp3)–H activation and C–N cleavage of N-methyl amines under transition-metal-free condition for synthesis of methylene-bridged bis-1,3-diketones

  摘要：

  A transition-metal-free oxidative methylenation reaction was developed. Methylene-bridged bis-1,3-dicarbonyl compounds were synthesized by oxidative C(Sp(3))-H activation and C-N cleavage of N-methyl amines. This novel reaction avoids the use of transition metal catalyst. Furthermore, the reaction are very mild and operational convenient. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.033

文献信息

• Facile synthesis of bis-1,3-dicarbonyl compounds using inert dichloromethane as a one-carbon source
  作者：Li-Ming Jiang、Kai Xiang、Hai-Juan Jiao、Jing-Lin Yang、Heng-Tong Qu、Xue-Tao Xu、Wen-Bao、Dao-Yong Zhu、Shao-Hua Wang

  DOI：10.1016/j.tetlet.2023.154564

  日期：2023.6

  simple and convenient procedure for the preparation of valuable bis-1,3-dicarbonyl-substituted methane compounds and their derivatives has been developed using inert dichloromethane as one-carbon source in good to excellent yields. The advantages of this protocol are mild reaction conditions, easily scalable and good functional group compatibility. Moreover, the use of cyclic secondary amine as the promoter

  使用惰性二氯甲烷作为单碳源，开发了一种制备有价值的双-1,3-二羰基取代的甲烷化合物及其衍生物的简单方便的方法，收率良好。该协议的优点是反应条件温和、易于扩展和良好的功能组兼容性。此外，使用环状仲胺作为促进剂避免了过渡金属催化剂和氧化剂的存在。
• Oxidative C(Sp3)–H activation and C–N cleavage of N-methyl amines under transition-metal-free condition for synthesis of methylene-bridged bis-1,3-diketones
  作者：Xiaohu Wang、Yi Wang、Yu Yuan、Chun-Hui Xing

  DOI：10.1016/j.tet.2014.01.033

  日期：2014.3

  A transition-metal-free oxidative methylenation reaction was developed. Methylene-bridged bis-1,3-dicarbonyl compounds were synthesized by oxidative C(Sp(3))-H activation and C-N cleavage of N-methyl amines. This novel reaction avoids the use of transition metal catalyst. Furthermore, the reaction are very mild and operational convenient. (C) 2014 Elsevier Ltd. All rights reserved.