5,6-dimethyl-1',2',5',6'-tetrahydro-[2,3']bipyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5,6-dimethyl-1',2',5',6'-tetrahydro-[2,3']bipyridine
• 英文别名: 5,6-dimethyl-1',2',5',6'-tetrahydro-2,3'-bipyridine；2,3-dimethyl-6-(1,2,3,6-tetrahydropyridin-5-yl)pyridine
• 化学式: C₁₂H₁₆N₂
• 分子量: 188.272
• InChiKey: ZMWZOLNLWIPCEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,6-dimethyl-1',2',5',6'-tetrahydro-[2,3']bipyridine 、 1-(((2R,3S),2-(2,4-二氟苯基)-3-甲基环氧乙烷-2-基)甲基)-1H-1,2,4-三唑 在 lithium perchlorate trihydrate 作用下， 以 乙腈 为溶剂， 反应 40.0h， 以35.7%的产率得到(2R,3R)-2-(2,4-difluorophenyl)-3-(5,6-dimethyl-5',6'-dihydro-2,3'-bipyridin-1'(2'H)-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
  参考文献：
  名称：

  TRIAZOLE DERIVATIVE OR SALT THEREOF

  摘要：

  提供了一种三唑衍生物或其药学上可接受的盐，该三唑衍生物由式（I）表示：其中*表示不对称碳，并采用R构型或S构型；R1表示由式（II）或（III）表示的结构：表示单键或双键，其中Y表示氢原子或氧原子；R2和R3各自独立地表示氢原子，烷基，芳基，烷氧基，甲酰基，羧基，烷基羰基，芳基羰基，烷氧羰基，氨基，烷基羰胺基，芳基羰胺基，氰基，硝基或卤素原子。

  公开号：

  US20090299071A1
• 作为产物：
  描述：

  5,6-dimethyl-2,3' bipyridine 在 palladium 10% on activated carbon 溴甲苯 、 氢气 、 三乙胺 作用下， 以 异丙醇 为溶剂， 50.0~80.0 ℃ 、196.0 kPa 条件下， 反应 8.0h， 以20%的产率得到5,6-dimethyl-1',2',5',6'-tetrahydro-[2,3']bipyridine
  参考文献：
  名称：

  EP1657240

  摘要：

  公开号：

文献信息

• Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them
  申请人：Kuwabara Hirokazu

  公开号：US20070093528A1

  公开（公告）日：2007-04-26

  The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.

  本发明提供了吡啶衍生物，作为药物和农业化学品的中间体，电子照相感受器，染料等。更具体地，本发明涉及新型吡啶基四氢吡啶和新型吡啶基哌啶，以及通过双吡啶衍生物和苯甲醰或苄氧羰基卤化物反应，并在钯催化剂、铂催化剂、钌催化剂或铑催化剂的帮助下还原所得反应产物的吡啶衍生物制备方法。
• Pyridyltetrahydropyridines and Pyridylpiperidines, and Method of Manufacturing Them
  申请人：Kuwabara Hirokazu

  公开号：US20100029947A1

  公开（公告）日：2010-02-04

  The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.

  本发明提供了吡啶衍生物，可用作药物和农业化学品，电子照相受体，染料等的中间体。更具体地说，本发明涉及新型吡啶基四氢吡啶和新型吡啶基哌啶，以及通过双吡啶衍生物和苯甲醰或苄氧羰基卤化物的反应制备吡啶衍生物的方法，并借助钯催化剂、铂催化剂、钌催化剂或铑催化剂还原所得反应产物的方法。
• Triazole derivative or salt thereof
  申请人：Fujifilm Finechemicals Co., Ltd

  公开号：US07973056B2

  公开（公告）日：2011-07-05

  A triazole derivative or pharmaceutically acceptable salt thereof is provided, the triazole derivative being represented by formula (I): wherein * represents an asymmetric carbon and takes R configuration or S configuration; and R1 represents a structure represented by formula (II) or (III): represents single bond or double bond wherein Y represents a hydrogen atom or an oxygen atom; and R2 and R3 each independently represent a hydrogen atom, an alkyl group, an aryl group, an alkoxy group, a formyl group, a carboxyl group, an alkylcarbonyl group, an arylcarbonyl group, an alkoxycarbonyl group, a carbamoyl group, an amino group, an alkylcarbonylamino group, an arylcarbonylamino group, a cyano group, a nitro group or a halogen atom.

  提供了一种三唑衍生物或其药学上可接受的盐，该三唑衍生物由公式（I）表示： 其中*代表不对称碳，并采用R构型或S构型；R1代表由公式（II）或（III）表示的结构：表示单键或双键 其中Y代表氢原子或氧原子；R2和R3各自独立地表示氢原子，烷基，芳基，烷氧基，甲酰基，羧基，烷基羰基，芳基羰基，烷氧羰基，氨基甲酰基，烷基羰胺基，芳基羰胺基，氰基，硝基或卤素原子。
• Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them
  申请人：Kuwabara Hirokazu

  公开号：US08530662B2

  公开（公告）日：2013-09-10

  The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.

  本发明提供了吡啶衍生物，可用作药物和农业化学品的中间体、电子照相感受器、染料等。更具体地，本发明涉及新型吡啶基四氢吡啶和新型吡啶基哌啶，以及通过双吡啶衍生物和苯甲酰卤或苄氧羰基卤之间的反应制造吡啶衍生物的方法，并借助钯催化剂、铂催化剂、钌催化剂或铑催化剂对所得反应产物进行还原。
• PYRIDYLTETRAHYDROPYRIDINES, PYRIDYLPIPERIDINES, AND PROCESS FOR THE PRODUCTION OF BOTH
  申请人：FUJIFILM FINECHEMICALS CO., LTD.

  公开号：EP1657240A1

  公开（公告）日：2006-05-17

  The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.

  本发明提供的吡啶衍生物可用作药物和农药、电致发光受体、染料等的中间体。更具体地说，本发明涉及新型吡啶四氢吡啶和新型吡啶哌啶，还涉及一种通过联吡啶衍生物与苄基卤化物或苄氧羰基卤化物反应，然后借助钯催化剂、铂催化剂、钌催化剂或铑催化剂还原反应产物来制造吡啶衍生物的方法。