3-hydroxy-3-(3-nitrophenyl)propanenitrile | 1007364-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-hydroxy-3-(3-nitrophenyl)propanenitrile
• CAS: 1007364-23-9
• 化学式: C₉H₈N₂O₃
• 分子量: 192.174
• InChiKey: HWIYPEAMNPRJQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  89.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-hydroxy-3-(3-nitrophenyl)propanenitrile 在 钯 氢气 、 钯 作用下， 以 乙酸乙酯 为溶剂， 反应 15.0h， 以to give 3-(3-aminophenyl)-3-hydroxypropanenitrile (12) as while solid的产率得到3-(3-aminophenyl)-3-hydroxypropanenitrile
  参考文献：
  名称：

  COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS

  摘要：

  提供了化合物、药物组合物及其治疗眼科疾病和疾患的方法，例如年龄相关性黄斑退化和Stargardt病，使用上述化合物和组合物进行治疗。

  公开号：

  US20100113539A1
• 作为产物：
  描述：

  间硝基苯甲醛 、 乙腈 在 lithium diisopropyl amide 、 水 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 以77%的产率得到3-hydroxy-3-(3-nitrophenyl)propanenitrile
  参考文献：
  名称：

  [EN] COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  [FR] COMPOSÉS DE TRAITEMENT DE MALADIES ET TROUBLES OPHTALMIQUES

  摘要：

  公开号：

  WO2010048332A3

文献信息

• Compounds for treating ophthalmic diseases and disorders
  申请人：Scott Ian L.

  公开号：US08674137B2

  公开（公告）日：2014-03-18

  Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  提供的是化合物、药物组合物及其治疗眼科疾病和疾病的方法，例如年龄相关性黄斑部病变和Stargardt病，使用这些化合物和组合物进行治疗。
• N-Heterocyclic carbene-catalyzed cyanomethylation of aldehydes with TMSAN
  作者：Ye-Cheng Fan、Guang-Fen Du、Wan-Fu Sun、Wei Kang、Lin He

  DOI：10.1016/j.tetlet.2012.02.080

  日期：2012.4

  N-Heterocyclic carbenes (NHCs) have been served as efficient catalysts for cyanomethylation of carbonyl compounds. In the presence of 5 mol % NHC, various aldehydes and 2,2,2-trifluoroacetophenone reacted with trimethylsilylacetonitrile (TMSAN) to give beta-hydroxynitriles in moderate to high yields. (c) 2012 Elsevier Ltd. All rights reserved.
• Choline chloride based eutectic solvents: Magical catalytic system for carbon–carbon bond formation in the rapid synthesis of β-hydroxy functionalized derivatives
  作者：Balvant Shyam Singh、Hyacintha Rennet Lobo、Ganapati Subray Shankarling

  DOI：10.1016/j.catcom.2012.03.021

  日期：2012.7

  Significant beta-hydroxy functionalized derivatives including nitroaldols, beta-hydroxy nitriles and beta-hydroxy carboxylic acids were successfully prepared, for the first time, by catalytic use of deep eutectic solvents (DES). This paper explores the versatility and effectiveness of DES as catalyst in three different carbon-carbon bond formation reactions. The uniqueness of this catalyst lies in its simplicity since it avoids expensive catalysts and multi-step synthesis as reported in literature. The compounds, which are potent intermediates for innumerable useful products, were synthesized in excellent yields within very short reaction times. The catalyst prepared from choline chloride and urea, is biodegradable, non-toxic, cost-effective and recyclable. (C) 2012 Elsevier B.V. All rights reserved.
• US8674137B2
  申请人：——

  公开号：US8674137B2

  公开（公告）日：2014-03-18
• US9193669B2
  申请人：——

  公开号：US9193669B2

  公开（公告）日：2015-11-24