Sodium cacodylate appears as a white crystalline or granular solid with a slight odor. Toxic by ingestion, inhalation, and skin absorption. Used as a herbicide.
颜色/状态：
Colorless to light yellow
气味：
None
密度：
>1 at 20 °C (solid) (est)
分解：
When heated to decomposition it emits toxic fumes of /arsenic & sodium oxide/.
腐蚀性：
Corrodes common metals, but reaction is not hazardous.
... METAB OF CACODYLIC ACID IN BLACK VALENTINE BEANS /WAS STUDIED/. ANALYSIS OF THE EXTRACT REVEALED AS, PRESUMED TO BE CACODYLIC ACID /CA/, IN THE CHROMATOGRAM WHERE CA SHOULD HAVE BEEN. THE ABSENCE OF AS3+ & MSMA /MONOSODIUM METHANEARSONATE/ WAS DEMONSTRATED. IN SEPARATE EXPT, NO ARSINE ... DETECTED EVEN THOUGH SEVERE TOXICITY DEVELOPED ... . IN CONCLUSION, APPARENTLY NO DEGRADATION OF CACODYLIC ACID OCCURS IN PLANTS BASED ON LIMITED STUDIES. VARIOUS ORGANISMS, HOWEVER, ARE CAPABLE OF REDUCING CACODYLIC ACID TO DI- OR TRIMETHYLARSINE. /CACODYLIC ACID/
来源:Hazardous Substances Data Bank (HSDB)
代谢
METHANOBACTERIUM SPECIES (STRAIN M.OH) IN AN INCUBATION MIXTURE UNDER ANAEROBIC CONDITIONS REDUCED CACODYLIC ACID TO DIMETHYLARSINE IN ABSENCE OF A C-1 DONOR. /CACODYLIC ACID/
甲烷菌种（菌株M.OH）在厌氧条件下的孵化混合物中，在没有C-1供体的情况下，将 cacodylic 酸还原为二甲胂。/cacodylic 酸/
METHANOBACTERIUM SPECIES (STRAIN M.OH) IN AN INCUBATION MIXTURE UNDER ANAEROBIC CONDITIONS REDUCED CACODYLIC ACID TO DIMETHYLARSINE IN ABSENCE OF A C-1 DONOR. /CACODYLIC ACID/
CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: No human data and inadequate data in animals. HUMAN CARCINOGENICITY DATA: None. /cacodylic acid/
Muscarinic receptorsare altered by sulfhydryl reagents. Arsenic cmpd, which have been used as insecticides, exert their toxic effects by combining with sulfhydryl groups. The action of arsenicals on the muscarinic receptor from invertebrate and vertebrate species (locust and rat) was compared. Disulfide reducing reagents dithiothreitol and British Anti-Lewisite, but not arsenicals, inhibited (3)H quinuclidinyl benzilate binding. However, after disulfide reduction, arsenicals caused a further inhibition of muscarinic binding. The effect of dithiothreitol + arsenicals was largely irreversible. The locust receptors were more sensitive to the action of both disulfide reagents either in the absence or presence of arsenicals than the rat receptors. The sulfhydryl reagent p-chloromercuric benzoate was more effective at inhibiting the locust receptors than the rat receptors, but addition of arsenicals did not cause further inhibition in either the locust or rat receptors. In locust, dithiothreitol + cacodylate and dithiothreitol + arsenite caused a reduction in the number of sites without modifying the affinity of (3)H quinuclidinyl benzilate binding. In rat, dithiothreitol + arsenite caused a decrease in the affinity, while dithiothreitol + cacodylate caused a decrease in the affinity of (3)H quinuclidinyl benzilate binding and its number of sites. Competition experiments after dithiothreitol + cacodylate showed that the IC50 remained unchanged in the locust. In the rat, the IC50 for atropine was increased and increased for carbachol. These results are explained assuming that the binding site of the locust receptor has a disulfide group similar to that of the mammalian receptor, but that th hydrophobic interactions within the binding site are weaker in the locust receptor.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
人类毒性摘录
强烈的大蒜气味会传到呼吸、汗液和尿液中。
STRONG GARLIC ODOR IS IMPARTED TO BREATH, SWEAT, & URINE.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
人类毒性摘录
摄入或过量吸入会导致胃和肠道刺激，出现恶心、呕吐、腹泻、休克、快速脉搏、昏迷。
Ingestion or excessive inhalation causes irritation of stomach and intestines with nausea, vomiting, diarrhea, shock, rapid pulse, coma.
FIVE DOSES OF SODIUM CACODYLATE (194 MG) WERE ADMIN IV TO 2 HORSES AT 2 DAY INTERVALS. URINARY ARSENIC CONTENT WAS DETERMINED FOR 5 DAYS AFTER FINAL DOSE AT WHICH TIME CONCN WERE CLOSE TO CONTROL SAMPLES. ORG ARSENICALS ARE MORE RAPIDLY EXCRETED BY ANIMALS THAN INORG CMPD.
Between MOFs and molecules: organolead(IV) compounds with chain structures
作者：Abdel-Fattah Shihada、Frank Weller、Werner Massa
DOI：10.1107/s2053229618004850
日期：2018.5.1
O′:O′)diphenyllead(IV)], [Pb(C6H5)2(C2H6AsO2)Cl]n or [(Ph2ClPb)(O2AsMe2)], (2), together with the triphenyllead(IV) diphenylphosphinate catena‐poly[[triphenyllead(IV)]‐μ‐diphenylphosphinato‐κ2O:O′], [Pb(C6H5)3(C12H10O2P)]n or [(Ph3Pb)(O2PPh2)], (3), have been synthesized and characterized by single‐crystal X‐ray diffraction, IR spectroscopy and mass spectrometry. In (1), a chain structure was found with alternating
Multiply bridged organodiantimony(V) compounds; crystal structures of [(SbR2)2(μ-O)2(μ -O2AsMe2)2] (R = Ph or p-tolyl) and [(SbR3)2(μ-O)(μ-O2 MR′2)2] (R = Ph, M = P, R′ = Me; R = Ph, M = As, R′ = Me or Ph; R = p-tolyl, M = P, R′ = Me)
作者：Martin N. Gibbons、D. Bryan Sowerby
DOI：10.1039/a702244a
日期：——
A number of quadruply and triply bridged
organodiantimony(V) compounds have been synthesized by
reactions of [(SbR
2
BrO)
2
] (R = Ph or
p-tolyl) and [(SbR
3
X)
2
O]
(R = Ph or p-tolyl, X = Br or Cl)
with Na(O
2
AsMe
2
),
Na(O
2
AsPh
2
) or Na(O
2
AsMe
2
).
The compounds have been characterised by a range of spectroscopic
methods and crystal structures are reported for two quadruply bridged,
[(SbPh
2
)
2
(µ-O)
2
(µ
-O
2
AsMe
2
)
2
] and
[Sb(p-MeC
6
H
4
)
2
}
2
(µ-O)
2
(µ-O
2
AsMe
2
)
2
], and four triply bridged compounds,
[(SbPh
3
)
2
(µ-O)(µ-O
2
PMe
2
)
2
],
[(SbPh
3
)
2
(µ-O)(µ-O
2
AsMe
2
)
2
],
[(SbPh
3
)
2
(µ-O)(µ-O
2
AsPh
2
)
2
] and
[Sb(p-MeC
6
H
4
)
3
}
2
(µ-O)(µ-O
2
PMe
2
)
2
]. Related trimethylantimony(V) compounds,
i.e.
[SbMe
3
(O
2
PMe
2
)}
2
O] and
[SbMe
3
(O
2
AsPh
2
)}
2
O], which are highly moisture sensitive, have also been
obtained.
The X-ray crystal structure and EXAFS measurements are reported for a newly synthesised unsymmetrical dinuclear iron(III) complex representing the first diferric compound with a single bridging arsenato group.
Five new dinuclear model complexes for zinc-containing phosphatases with dinucleating ligands have been prepared and characterized by single-crystal X-ray crystallography. The heterodinuclear, μ-alkoxo-bridged zinc(II)−iron(III) complexes 1−3 contain the symmetric ligands N,N,N′,N′-tetrakis[2-(5,6-dimethyl)benzimidazolylmethyl]-1,3-diamino-2propanol (Htdmbpo) and N,N,N′,N′-tetrakis2-[N′′-(2hydrox
Discovery and Supramolecular Interactions of Neutral Palladium‐Oxo Clusters Pd
<sub>16</sub>
and Pd
<sub>24</sub>
作者：Saurav Bhattacharya、Uttara Basu、Mohamed Haouas、Pei Su、Michael Forrester Espenship、Fei Wang、Albert Solé‐Daura、Dereje H. Taffa、Michael Wark、Josep M. Poblet、Julia Laskin、Emmanuel Cadot、Ulrich Kortz
DOI：10.1002/anie.202010690
日期：2021.2.15
cluster [Pd24O44(OH)8((CH3)2As)16] (Pd24) can be considered as a bicapped derivative of Pd16 with a tetra‐palladium‐oxo unit grafted on either side. The three compounds were fullycharacterized 1) in the solid state by single‐crystal and powder XRD, IR, TGA, and solid‐state 1H and 13C NMR spectroscopy, 2) in solution by 1H, 13C NMR and 1H DOSY spectroscopic methods, and 3) in the gas phase by electrospray
我们报告了中性钯氧簇（POC）的前三个例子的合成、结构和物理化学表征。 16-钯(II)-氧代簇[Pd 16 O 24 (OH) 8 ((CH 3 ) 2 As) 8 ] ( Pd 16 )包含由八个二甲基胂酸基团封端的环状钯-氧代单元。还制备了氯代衍生物[Pd 16 Na 2 O 26 (OH) 3 Cl 3 ((CH 3 ) 2 As) 8 ] ( Pd 16 Cl )，它通过强分子间相互作用形成高度稳定的3D超分子晶格。 24-钯(II)-氧代簇[Pd 24 O 44 (OH) 8 ((CH 3 ) 2 As) 16 ] ( Pd 24 ) 可以被认为是Pd 16与四-钯-氧代的双帽衍生物单位嫁接在两侧。这三种化合物在 1) 固态下通过单晶和粉末 XRD、IR、TGA 以及固态1 H 和13 C NMR 光谱进行了充分表征，2) 在溶液中通过1 H、 13 C NMR 和1 H 进行了表征DOSY
