N,N-diethylacetatochloroacetamide | 409303-47-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-diethylacetatochloroacetamide
• 英文别名: diethyl 2,2-(2-chloroacetylamino)diacetate；2,2-(2-chloroacetyl-amino)diacetate；Ethyl 2-[(2-chloroacetyl)-(2-ethoxy-2-oxoethyl)amino]acetate
• CAS: 409303-47-5
• 化学式: C₁₀H₁₆ClNO₅
• 分子量: 265.694
• InChiKey: XKYJJUJWKNSDNW-UHFFFAOYSA-N

物化性质

• 沸点：
  364.8±37.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N,N-diethylacetatochloroacetamide 在 DL-dithiothreitol 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 ({2-[[(Bis-ethoxycarbonylmethyl-carbamoyl)-methyl]-(2-mercapto-ethyl)-amino]-acetyl}-ethoxycarbonylmethyl-amino)-acetic acid ethyl ester
  参考文献：
  名称：

  Stabilization of Inorganic Nanocrystals by Organic Dendrons

  摘要：

  A series of hydrophilic organic dendron ligands was designed and synthesized for stabilizing high-quality semiconductor and noble metal nanocrystals. The focal point of the dendron ligands is chosen to be a thiol group which is a universal coordinating site for compound semiconductor and noble metal nanocrystals. The methods for binding these dendron ligands onto the surface of the nanocrystals are simple and straightforward. The thin, about 1-2 nm, but closely packed and tangled ligand she[[ provides sufficient stability for the "dendron-protected nanocrystals" to withstand the rigors of the coupling chemistry and the standard separation/purification techniques. The chemistry presented can be immediately applied for the development of a new generation of biomedical labeling reagents based on high-quality semiconductor nanocrystals. It also provides an alternative path to apply noble metal nanocrystals for developing sensitive detection schemes for chemical and biochemical purposes. The concept may further provide an optimal solution for many other problems encountered in nanocrystal-related research and development, for which the stability of the nanocrystals is a critical issue. Furthermore, the experimental results confirmed that the photochemical stability of colloidal semiconductor and noble metal nanocrystals is the key for developing reliable and reproducible processing chemistry for these nanocrystals.

  DOI：

  10.1021/ja016711u
• 作为产物：
  描述：

  亚氨基二乙酸二乙酯 、 氯乙酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以92%的产率得到N,N-diethylacetatochloroacetamide
  参考文献：
  名称：

  基于环镧系元素的胶束结构，可用作发光[Eu（III）]和磁性[Gd（III）]共振成像（MRI）造影剂

  摘要：

  提出了一种新型的基于Ln（III）的两亲性配合物，具有潜在的发光和MRI造影剂的作用，它们在水溶液中自组装成球形胶束。

  DOI：

  10.1039/c6cc03092k

文献信息

• An iminodiacetate-modified conjugated polyelectrolyte for fluorescent labeling of histidine-tagged proteins
  作者：Kai Cai、Ying Tan、Chunyan Tan、Jiatao Wu、Pan Wu、Jiamei Liang、Shuwen Liu、Bibo Zhang、Yuyang Jiang

  DOI：10.1039/c7cc00850c

  日期：——

  The iminodiacetate-Ni(II)-hexahistidine system is extensively used in protein purification. In this study, an anionic conjugated polyelectrolyte (CPE) with a poly(p-pheynylene ethynylene) backbone and iminodiacetate side chains, named PPEIDA, was designed...

  亚氨基二乙酸酯-Ni（II）-六组氨酸系统广泛用于蛋白质纯化。在这项研究中，设计了一种具有聚对苯乙炔乙炔主链和亚氨基二乙酸酯侧链的阴离子共轭聚电解质（CPE），名为PPEIDA。
• Selective Imaging of Damaged Bone Structure (Microcracks) Using a Targeting Supramolecular Eu(III) Complex As a Lanthanide Luminescent Contrast Agent
  作者：Brian McMahon、Peter Mauer、Colin P. McCoy、T. Clive Lee、Thorfinnur Gunnlaugsson

  DOI：10.1021/ja908006r

  日期：2009.12.9

  The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range and its steady state emission is not significantly modulated by a series of group I and II as well as D-metal ions and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 h, using confocal laser-scanning microscopy.