N-α-methoxyethyl-N-methyl-acetamide | 77388-53-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-α-methoxyethyl-N-methyl-acetamide
• 英文别名: N-(1-methoxyethyl)-N-methylacetamide；N-alpha-methoxyethyl-N-methyl-acetamide
• CAS: 77388-53-5
• 化学式: C₆H₁₃NO₂
• 分子量: 131.175
• InChiKey: UNMKZYQZANPURY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-α-methoxyethyl-N-methyl-acetamide 生成 N-甲基-N-乙烯基乙酰胺
  参考文献：
  名称：

  METHOD FOR PRODUCING N-METHYL-N-VINYLACETAMIDE HAVING IMPROVED STABILITY AND POLYMERIZABILITY

  摘要：

  本发明涉及一种生产N-甲基-N-乙烯基乙酰胺的方法，其中包括控制N-1,3-丁二烯基-N-甲基乙酰胺在N-甲基-N-乙烯基乙酰胺中的含量为0.01-150 ppm的步骤。该方法使得能够生产具有稳定质量的N-甲基-N-乙烯基乙酰胺，可以在稳定性和聚合性作为单体中进行控制。通过该方法生产的N-甲基-N-乙烯基乙酰胺能够生产具有稳定物理性质，如分子量的N-甲基-N-乙烯基乙酰胺聚合物。

  公开号：

  EP2239250A1
• 作为产物：
  描述：

  1-氯-1-甲氧基乙烷 在 sodium hydroxide 、 三乙胺 作用下， 以 N-甲基乙酰胺 、 正己烷 为溶剂， 生成 N-α-methoxyethyl-N-methyl-acetamide
  参考文献：
  名称：

  Process for the preparation of N-.alpha.-alkoxyalkyl-carboxamides, and

  摘要：

  N-.alpha.-Alkoxyalkyl-羧酰胺是通过将脂肪族、芳基脂肪族或芳香族羧酸的一级或二级酰胺，或者不能形成芳香体系的开链α-卤代烷醚与每个分子至少有3个碳原子的环状羧酰胺（内酰胺）在三级胺存在下反应制备的。N,N-双α-烷氧基烷基羧酰胺也可以从一级羧胺中得到。其中化合物V和VI的反应产物是新的，其中R⁴=C-C⁴-烷基且R⁵=CH₃或C₂H₅，主要用于制备N-烯基或N-乙烯基羧酰胺的中间体，其中化合物VII又是新的。N-烯基或N-乙烯基羧酰胺本身可以加工成有价值的均聚物和共聚物。

  公开号：

  US04334097A1

文献信息

• Process for the preparation of N-vinyl-N-alkyl-carboxylic acid amides
  申请人：Hoechst Aktiengesellschaft

  公开号：US04322271A1

  公开（公告）日：1982-03-30

  N-Vinyl-N-alkyl-carboxylic acid amides are prepared, starting from N-ethyl-carboxylic acid amides, in a 3-stage process consisting of the following stages: (a) anodic alkoxylation of the N-ethyl-carboxylic acid amides to give N-.alpha.-alkoxyethyl-carboxylic acid amides; (b) alkylation of these N-.alpha.-alkoxyethyl-carboxylic acid amides with an alkyl halide or dialkyl sulfate in an alkaline medium to give N-.alpha.-alkoxyethyl-N-alkyl-carboxylic acid amides; and (c) splitting off of alcohol from the products of stage (b) by heating to temperatures between about 60.degree. and about 350.degree. C. Instead of stages (b) and (c), it is also possible to carry out the following stages after stage (a): (b.sub.1) splitting off of alcohol from the N-.alpha.-alkoxyethylcarboxylic acid amides obtained in stage (a) by heating to temperatures of about 60.degree. to about 600.degree. C., to give N-vinyl-carboxylic acid amides; and (c.sub.1) alkylation of these N-vinyl-carboxylic acid amides by reaction with an alkylating agent of the same type as in stage (b) in an alkaline medium. The N-vinyl-N-alkyl-carboxylic acid amides obtained by the process are valuable intermediate products, in particular for the manufacture of homopolymers and copolymers with interesting properties.

  N-乙基羧酸酰胺经过3个阶段的过程制备N-乙烯基-N-烷基-羧酸酰胺，包括以下阶段：(a) 将N-乙基羧酸酰胺进行阳极烷氧基化，得到N-α-烷氧乙基羧酸酰胺；(b) 在碱性介质中用烷基卤化物或二烷基硫酸盐烷基化这些N-α-烷氧乙基羧酸酰胺，得到N-α-烷氧乙基-N-烷基羧酸酰胺；(c) 通过加热至约60度至约350度C的温度，从(b)阶段产物中分离出醇。在(a)阶段之后，也可以执行以下阶段代替(b)和(c)阶段：(b.sub.1) 将在(a)阶段获得的N-α-烷氧乙基羧酸酰胺加热至约60度至约600度C，分离出醇，得到N-乙烯基羧酸酰胺；(c.sub.1) 将这些N-乙烯基羧酸酰胺在碱性介质中通过与与(b)阶段相同类型的烷基化剂反应进行烷基化。该过程获得的N-乙烯基-N-烷基-羧酸酰胺是有价值的中间产物，特别适用于制造具有有趣性能的均聚物和共聚物。
• N-(1-HYDROXYETHYL ) CARBOXAMIDE COMPOUND AND PROCESS FOR PRODUCING SAME
  申请人：Ohta Keisuke

  公开号：US20110294974A1

  公开（公告）日：2011-12-01

  The present invention relates to an N-(1-hydroxyethyl)carboxamide compound represented by formula (1) (in the formula, R A and R B represent independently from each other a hydrogen atom or an alkyl group having 1 to 4 carbon atoms except for a case where R A and R B represent a hydrogen atom at the same time) and a method for producing the same; a method for producing an N-(1-alkoxyethyl)carboxamide compound; a method for producing an N-vinyl carboxylic acid amide compound; and a method for producing an N-vinyl carboxylic acid amide (co)polymer. An N-(1-alkoxyethyl)carboxamide compound can be obtained by reacting N-(1-hydroxyethyl)carboxamide compound with alcohol in the presence of an acid catalyst, and an N-vinyl carboxylic acid amide compound, which is a monomer of the N-vinyl carboxylic acid amide (co)polymer, can be obtained by thermally decomposing or catalytically decomposing the N-(1-alkoxyethyl)carboxamide compound.

  本发明涉及一种由式（1）表示的N-（1-羟乙基）羧酰胺化合物（在该式中，RA和RB独立地表示氢原子或具有1至4个碳原子的烷基，除非RA和RB同时表示氢原子），以及其制备方法；一种制备N-（1-烷氧基乙基）羧酰胺化合物的方法；一种制备N-乙烯基羧酸酰胺化合物的方法；以及一种制备N-乙烯基羧酸酰胺（共）聚合物的方法。在酸催化剂存在下，可以通过将N-（1-羟乙基）羧酰胺化合物与醇反应来获得N-（1-烷氧基乙基）羧酰胺化合物，而将N-（1-烷氧基乙基）羧酰胺化合物热分解或催化分解可以获得N-乙烯基羧酸酰胺化合物，后者是N-乙烯基羧酸酰胺（共）聚合物的单体。
• COMPOSITION FOR PRODUCING N-VINYL CARBOXYLIC ACID AMIDE
  申请人：SHOWA DENKO K.K.

  公开号：US20220112155A1

  公开（公告）日：2022-04-14

  The present invention relates to a composition for producing an N-vinylcarboxylic acid amide, the composition including (A) an N-(1-alkoxyethyl)carboxylic acid amide and (B) a carboxylic acid amide other than the N-(1-alkoxyethyl)carboxylic acid amide and the N-vinylcarboxylic acid amide, and satisfying the following conditions (1) to (4): (1) the composition has a melting point of 0 to 30° C.; (2) a water content is 0 to 1.00% by mass in a total amount of the composition; (3) a content ratio of the component (A) to the component (B) is 4.0 to 20.0 in terms of a molar ratio; and (4) a 5% by mass aqueous solution of the composition has a pH of 4.0 to 8.0. The present invention also relates to a method for producing an N-vinylcarboxylic acid amide, the method including thermally decomposing or catalytically decomposing the composition for producing an N-vinylcarboxylic acid amide.

  本发明涉及一种用于生产N-乙烯基羧酸酰胺的组合物，该组合物包括（A）N-(1-烷氧基乙基)羧酸酰胺和（B）除N-(1-烷氧基乙基)羧酸酰胺和N-乙烯基羧酸酰胺以外的羧酸酰胺，并满足以下条件（1）至（4）：（1）组合物的熔点为0至30℃；（2）组合物总量中的水含量为0至1.00%质量分数；（3）组分（A）与组分（B）的含量比为摩尔比4.0至20.0；（4）组合物的5%质量分数水溶液的pH值为4.0至8.0。本发明还涉及一种生产N-乙烯基羧酸酰胺的方法，该方法包括热分解或催化分解上述用于生产N-乙烯基羧酸酰胺的组合物。
• METHOD OF PRODUCING N-VINYLCARBOXYLIC ACID AMIDE
  申请人：SHOWA DENKO K.K.

  公开号：US20210214302A1

  公开（公告）日：2021-07-15

  A method for producing an N-vinylcarboxylic acid amide is provided, the method focusing on unsaturated aldehydes that are contained as impurities generated during a reaction. The method for producing an N-vinylcarboxylic acid amide includes a step for controlling the contained amount of unsaturated aldehydes in the N-vinylcarboxylic acid amide to be not more than 20 mass ppm.

  提供了一种生产N-乙烯基羧酸酰胺的方法，该方法侧重于在反应过程中生成的不饱和醛作为杂质。生产N-乙烯基羧酸酰胺的方法包括一步，控制N-乙烯基羧酸酰胺中含有的不饱和醛的含量不超过20质量ppm。
• RAW MATERIAL FEEDER AND N-VINYLCARBOXYLIC ACID AMIDE PRODUCTION METHOD
  申请人：Showa Denko K.K.

  公开号：EP3888770A1

  公开（公告）日：2021-10-06

  Provided are a raw material feeder and a method of producing N-vinylcarboxylic acid amide, in which a raw material is fed to a plurality of evaporation tubes of a falling film evaporator with a stable raw material dispersibility, so that a problem of a thermal decomposition reactor being blocked due to coagulum can be inhibited, and an operation can be stably and continuously performed for a long period of time. A raw material feeder to distribute and feed a liquid compound as a raw material to a plurality of evaporation tubes 8 of a falling film evaporator comprises a main body section 51 comprising a plurality of communication holes 50 facing the plurality of evaporation tubes 8; a restriction orifice 7 housed in an interior of each of the communication holes 50, and comprising an orifice hole 7a; a liquid feeding tip 6 housed to face the restriction orifice 7 on an upstream side of the restriction orifice 7 in the interior of the communication hole 50, and comprising a hole portion 6a facing the orifice hole 7a; a first O-ring 10 fitted into a side surface of the liquid feeding tip 6 from outside, and sandwiched between the side surface of the liquid feeding tip 6 and an inner surface of the communication hole 50; and a second O-ring 11 sandwiched between the liquid feeding tip 6 and the restriction orifice 7 so that the orifice hole 7a is present in an inner region.

  本发明提供了一种原料进料器和一种生产 N-乙烯基羧酸酰胺的方法，在这种方法中，以稳定的原料分散性将原料送入降膜式蒸发器的多个蒸发管中，从而抑制了因凝结物而导致热分解反应器堵塞的问题，并可长期稳定、连续地进行操作。一种原料喂料器，用于将作为原料的液体化合物分配和喂入降膜式蒸发器的多个蒸发管 8，包括一个主体部分 51，该主体部分 51 包括多个朝向多个蒸发管 8 的通孔 50；一个限流孔 7，该限流孔 7 安装在每个通孔 50 的内部，并包括一个孔 7a；一个进液头 6，安装在通信孔 50 内部的限制孔 7 的上游侧，面向限制孔 7，并包括一个面向孔 7a 的孔部分 6a；一个第一 O 形环 10，从外部装入进液头 6 的侧表面，并夹在进液头 6 的侧表面和通信孔 50 的内表面之间；以及一个第二 O 形环 11，夹在进液头 6 和限制孔 7 之间，使孔 7a 位于内部区域。