2-(2-butoxyethoxy)ethyl chloroacetate | 6701-25-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-butoxyethoxy)ethyl chloroacetate
• 英文别名: 2-(2-butoxyethoxy)ethyl 2-chloroacetate
• CAS: 6701-25-3
• 化学式: C₁₀H₁₉ClO₄
• 分子量: 238.711
• InChiKey: JXFHXVGLAOFHQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-butoxyethoxy)ethyl chloroacetate 、 4-叔丁基杯[8]芳烃 在 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 120.0h， 以24.9%的产率得到2-(2-Butoxyethoxy)ethyl 2-[[50,51,52,53,54,55,56-heptakis[2-[2-(2-butoxyethoxy)ethoxy]-2-oxoethoxy]-5,11,17,23,29,35,41,47-octatert-butyl-49-nonacyclo[43.3.1.13,7.19,13.115,19.121,25.127,31.133,37.139,43]hexapentaconta-1(48),3,5,7(56),9,11,13(55),15,17,19(54),21,23,25(53),27(52),28,30,33(51),34,36,39(50),40,42,45(49),46-tetracosaenyl]oxy]acetate
  参考文献：
  名称：

  Novel Synthesis of p‐t‐Butylcalix[n]arenes Bearing Ethylene Glycol Ether Chains

  摘要：

  An approach for the synthesis of calixarene derivatives 3a-d, which contain ethylene glycol ether units at the lower rim in moderate yields, is described. The above compounds have been achieved by treating p-Butylcalix[n]arenes 1a-b (n = 6, 8) with chloroacetate 2a-b of 2-methoxyethanol and 2-(2-butoxyethoxy)ethanol in the system of K2CO3/Kl/acetone.

  DOI：

  10.1081/scc-200043196

文献信息

• Novel Synthesis of p‐t‐Butylcalix[n]arenes Bearing Ethylene Glycol Ether Chains
  作者：Chaoguo Yan、Lin An、Jing Sun

  DOI：10.1081/scc-200043196

  日期：2004.1

  An approach for the synthesis of calixarene derivatives 3a-d, which contain ethylene glycol ether units at the lower rim in moderate yields, is described. The above compounds have been achieved by treating p-Butylcalix[n]arenes 1a-b (n = 6, 8) with chloroacetate 2a-b of 2-methoxyethanol and 2-(2-butoxyethoxy)ethanol in the system of K2CO3/Kl/acetone.