6-hydroxy-6-methylheptanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 6-hydroxy-6-methylheptanoic acid
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: IJNLAYGCIOTLQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-hydroxy-6-methylheptanoic acid 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 Tert-butyl 6-[3-bromo-2-(bromomethyl)propanoyl]oxy-6-methylheptanoate
  参考文献：
  名称：

  [EN] ANTIBODY-DRUG CONJUGATES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
  [FR] CONJUGUÉS DE MOLÉCULES BIOLOGIQUEMENT ACTIVES, RÉACTIFS ET MÉTHODES DE FABRICATION, ET UTILISATIONS THÉRAPEUTIQUES

  摘要：

  公开号：

  WO2015187596A3
• 作为产物：
  描述：

  甲基碘化镁 、 5-乙酰基戊酸 以 四氢呋喃 、 甲苯 为溶剂， 以57%的产率得到6-hydroxy-6-methylheptanoic acid
  参考文献：
  名称：

  [EN] ANTIBODY-DRUG CONJUGATES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
  [FR] CONJUGUÉS DE MOLÉCULES BIOLOGIQUEMENT ACTIVES, RÉACTIFS ET MÉTHODES DE FABRICATION, ET UTILISATIONS THÉRAPEUTIQUES

  摘要：

  公开号：

  WO2015187596A3

文献信息

• POLYURETHANES
  申请人：Ercole Francesca

  公开号：US20120252967A1

  公开（公告）日：2012-10-04

  The present invention relates to a polyurethane polymer comprising as part of its polymer backbone an α-oxy carbonyl moiety of general formula (I), where A and B represent the remainder of the polymer backbone and are the same or different, and R is an optionally substituted aliphatic hydrocarbon having three or more carbon atoms.

  本发明涉及一种聚氨酯聚合物，其聚合物主链中包含通式(I)的α-氧基羰基基团，其中A和B代表聚合物主链的其余部分，可以相同也可以不同，R是具有三个或三个以上碳原子的可选择取代的脂肪族碳氢化合物。
• Process for the preparation of lactic acid polyesters
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0603889A2

  公开（公告）日：1994-06-29

  [Construction] In a preparation process of a polyhydroxycarboxylic acid comprising carrying out dehydration polycondensation of hydroxycarboxylic acids which contain at least lactic acid in an organic solvent in the presence or in the absence of a catalyst a preparation process of the polyhydroxycarboxylic acid comprising use of a raw material containing ethyllactate of which amount is 0.3 mole % or less to a reduced mole number of the raw material monomer. [Effect] A high molecular weight of polyhydroxycarboxylic acid is obtained with ease and with inexpensive industrially by a direct polycondensation of a hydroxycarboxylic acid which contains at least lactic acid.

  施工 在聚羟基羧酸的制备工艺中，包括在有机溶剂中，在有催化剂存在或无催化剂存在的情况下，对至少含有乳酸的羟基羧酸进行脱水缩聚，聚羟基羧酸的制备工艺包括使用含有乙内酯的原料，乙内酯的量占原料单体减少摩尔数的 0.3 摩尔%或更少。 效果 通过直接缩聚至少含有乳酸的羟基羧酸，可以方便地获得高分子量的聚羟基羧酸，而且工业成本低廉。
• Polyhydroxycarboxylic acid and purification process thereof
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0591978A2

  公开（公告）日：1994-04-13

  A purification process of a polyhydroxycarboxylic acid for efficiently removing a catalyst with a simple method from solid polyhydroxycarboxylic acid by bringing the solid polyhydroxycarboxylic acid which is obtained by a catalytic reaction and has an inherent viscosity of 0. 1 to 5. 0 dl/g into contact with an acid substance in the presence of a hydrophilic organic solvent and a polyhydroxycarboxylic acid prepared by direct dehydration polymerization having extremely reduced content of the residual catalyst.

  一种聚羟基羧酸的纯化工艺，它能以简单的方法从固体聚羟基羧酸中有效地去除催化剂，其方法是将通过催化反应得到的固有粘度为0.1至5.0分升/克的固体聚羟基羧酸在亲水性有机溶剂存在下与酸性物质接触，并将通过直接脱水聚合制备的聚羟基羧酸与残留催化剂含量极低的聚羟基羧酸接触。
• Purification process of polyhydroxycarboxylic acids
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0707024A2

  公开（公告）日：1996-04-17

  The invention relates to a purification process for polyhydroxycarboxylic acids which comprises dissolving a polyhydroxycarboxylic acid in an water-immiscible phenol or an organic solvent containing said water-immiscible phenol, successively bringing the resulting solution into contact with water which contains an acidic material, separating the organic layer from an aqueous layer, and isolating polyhydroxycarboxylic acid from the organic layer; and the process of the invention can efficiently remove a catalyst contained in polyhydroxycarbo xylic acid prepared in the presence of the catalyst, not always requires to take out polyhydroxycarboxylic acid in the form of a solid, and can treat polyhydroxycarboxylic acid in a higher concentration as compared with the case using chlorinated hydrocarbon as a solvent. Polyhydroxycarboxylic acid obtained by the purification process of the invention can be used for slow release drugs with safety. Polyhydroxycarboxylic acid of the invention has also excellent mechanical properties, heat resistance and weatherability, and thus is stable in a thermoforming stage, can be molded or processed with ease, and can be used for the material of various kinds of films and workpieces.

  本发明涉及一种多羟基羧酸的纯化工艺，该工艺包括将多羟基羧酸溶解在水不混溶苯酚或含有上述水不混溶苯酚的有机溶剂中，先后将所得溶液与含有酸性物质的水接触，从水层中分离出有机层，并从有机层中分离出多羟基羧酸；本发明的工艺可以有效地除去在催化剂存在下制备的聚羟基羧酸中所含的催化剂，不一定需要以固体形式取出聚羟基羧酸，而且与使用氯化烃作为溶剂的情况相比，可以处理更高浓度的聚羟基羧酸。 通过本发明的纯化工艺获得的聚羟基羧酸可安全地用于缓释药物。本发明的聚羟基羧酸还具有优异的机械性能、耐热性和耐候性，因此在热成型阶段稳定，可轻松成型或加工，并可用于各种薄膜和工件的材料。
• Process for preparing polycondensation polymers
  申请人：MITSUI TOATSU CHEMICALS, INC.

  公开号：EP0769512A2

  公开（公告）日：1997-04-23

  The invention provides a novel preparation process of a polycondensation type polymer, an excellent polymer which is represented by lactic acid and the preparation process of the polymer, a polycondensation agent used for the preparation process, and an intermediate. Specifically, the invention provides a preparation process of the polycondensation type polymer, for example, polyamide, polyimide, polythioester and polyester, comprising bonding a carboxyl group comprising compound with an active hydrogen group comprising compound in the presence of haloiminium salt. The invention provides excellent polylactic acid having a controlled D/L-isomer ratio in the repeating structural units and preparation process of polylactic acid, and further provides a haloiminium salt compound used for the preparation process and an intermediate compound of acid chloride.

  本发明提供了一种新型缩聚型聚合物的制备工艺、一种以乳酸为代表的优良聚合物及其制备工艺、一种用于制备工艺的缩聚剂和一种中间体。具体而言，本发明提供了一种缩聚型聚合物（例如聚酰胺、聚酰亚胺、聚硫酯和聚酯）的制备工艺，包括在卤化亚胺盐存在下，将包含羧基的化合物与包含活性氢基的化合物键合。本发明提供了在聚乳酸的重复结构单元和制备工艺中具有可控 D/L 异构体比率的优良聚乳酸，并进一步提供了用于制备工艺的卤化亚胺盐化合物和氯化酸的中间化合物。