2-庚烷磺酸 | 102881-70-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: 2-庚烷磺酸
• 英文名称: 2-heptanesulfonic acid
• 英文别名: n-Heptan-sulfonsaeure-(2)；heptane-2-sulfonic acid；Heptan-2-sulfonsaeure
• CAS: 102881-70-9
• 化学式: C₇H₁₆O₃S
• 分子量: 180.268
• InChiKey: PGFHUTLGRFUELA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正庚烷 在 二氧化硫 、 氧气 作用下， 生成 2-庚烷磺酸
  参考文献：
  名称：

  Toptschiew et al., Doklady Akademii Nauk SSSR, 1957, vol. 113, p. 1302

  摘要：

  DOI：

文献信息

• Sulfonic acids, their derivatives and pharmaceutical compositions containing them
  申请人：Dompé S.P.A.

  公开号：EP1457485A1

  公开（公告）日：2004-09-15

  Selected sulfonic acids, their derivatives and pharmaceutical compositions containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, the selected sulfonic acids and their derivativas are devoid of cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

  选择性磺酸、它们的衍生物和含有这些化合物的药物组合物在抑制由白细胞介素-8（IL-8）与CXCR1和CXCR2膜受体相互作用引起的中性粒细胞（PMN白细胞）趋化活化方面是有用的。这些化合物用于预防和治疗由该活化引起的病理状况。值得注意的是，所选的磺酸及其衍生物不具有环氧化酶抑制活性，特别适用于治疗中性粒细胞依赖性病理状况，如银屑病、溃疡性结肠炎、黑色素瘤、慢性阻塞性肺疾病（COPD）、大疱性类天疱疮、类风湿性关节炎、特发性纤维化、肾小球肾炎以及预防和治疗缺血再灌注引起的损伤。
• Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0536936A1

  公开（公告）日：1993-04-14

  Compounds of formula (I): [in which: R¹, R² and R³ are the same or different and each represents a hydrogen atom, an optionally substituted alkanoyl group or an alkenylcarbonyl group, provided that at least one of R¹, R² and R³ represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R⁴ and R⁵ represents a hydrogen atom and the other represents a cyano group]; have valuable anti-tumour activity.

  式子（I）的化合物：[其中：R¹、R²和R³相同或不同，每个代表氢原子、可选取代的脂肪酰基团或烯基羰基团，前提是至少有一个R¹、R²和R³代表有5到24个碳原子的未取代脂肪酰基团，或者是所述取代的脂肪酰基团或所述烯基羰基团；R⁴和R⁵中的一个代表氢原子，另一个代表氰基]，具有有价值的抗肿瘤活性。
• METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES
  申请人：Kong Xianqi

  公开号：US20140107027A1

  公开（公告）日：2014-04-17

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  本文描述了用于治疗或预防淀粉样蛋白相关疾病的方法、化合物、制药组合物和试剂盒。
• p-Hydroxyphenylglycine alpha-phenylethanesulfonate, process for production thereof and utilization thereof in resolution of p-hydroxyphenylglycine
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：EP0075318A2

  公开（公告）日：1983-03-30

  p-Hydroxyphenylglycine a-phenylethanesulfonate which is useful for the production of optically active p-hydroxyphenylglycine and optically active α-phenyl- ethansulfonic acid is disclosed. p-Hydroxyphenylglycine. α-phenylethanesulfonate is produced by either reacting DL-p-hydroxyphenylglycine with optically active a-phe- nylethansulfonic acid or reacting (±)-α-pentylethane- sulfonic acid with optically active p-hydroxyphenylglycine to form two diastereomers of DL-p-hydroxyphenylglycine optically active a-phenylethanesulfonate or optically active p-hydroxyphenylglycine (±)-α-phenylethansulfonate, and isolating one diastereomer according to the difference between solubilities of the diastereomers, optionally, combining selective crystallization of one diastereomer and epimerization of another diastereomer in the case of reaction of DL-p-hydroxyphenylglycine and optically active α-phenylethansufonic acid. This reaction is utilized in the resolution of p-hydroxyphenylglycine or α-phenylethanesulfonic acid by deacidifying the resulting diastereomer.

  本发明公开了可用于生产光学活性对羟基苯甘氨酸和光学活性α-苯乙烷磺酸的对羟基苯甘氨酸a-苯乙烷磺酸盐。α-苯乙烷磺酸盐是通过 DL-对羟基苯甘氨酸与光学活性的 a-苯乙烷磺酸反应，或通过 (±)-α-pentylethane- sulfonic acid 与光学活性的 p-羟基苯甘氨酸与光学活性对-羟基苯甘氨酸反应，形成光学活性 a-苯乙烷磺酸或光学活性对-羟基苯甘氨酸 (±)-α-苯乙烷磺酸的两种非对映异构体、根据非对映异构体溶解度的差异，分离出一种非对映异构体，在 DL 对羟基苯甘氨酸和光学活性 α-苯基乙磺酸反应的情况下，可选择性地将一种非对映异构体的选择性结晶和另一种非对映异构体的外延化结合起来。这种反应可用于对羟基苯甘氨酸或 α-苯乙烷磺酸的分解，对得到的非对映异构体进行脱酸处理。
• Mercury-photosensitized sulfination, hydrosulfination, and carbonylation of hydrocarbons: alkane and alkene conversion to sulfonic acids, ketones, and aldehydes
  作者：Richard R. Ferguson、Robert H. Crabtree

  DOI：10.1021/jo00019a006

  日期：1991.9

  Mercury-photosensitized sulfination of alkanes, RH, with SO2 forms sulfinic acids (RSOOH) and sulfinate esters (RSOOR) in high conversion and yield; oxidation of the mixture produces RSO2OH in high yield. Mercury-photosensitized hydrosulfination of alkenes with H2 and SO2 gives RSO2OH after oxidative workup. Mercury-photosensitized carbonylation of alkanes with CO gives RCHO and R2CO.