2,3,4,6-四氟-1,1'-联苯 | 2357-14-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3,4,6-四氟-1,1'-联苯
• 英文名称: 2,3,4,6-tetrafluoro-1,1'-biphenyl
• 英文别名: 2,3,4,6-tetrafluorobiphenyl；2,3,4,6-tetrafluoro-[1,1'-biphenyl]；2,3,4,6-tetrafluoro1,1'-biphenyl；2,3,4,6-Tetrafluorbiphenyl；1,2,3,5-tetrafluoro-4-phenylbenzene
• CAS: 2357-14-4
• 化学式: C₁₂H₆F₄
• 分子量: 226.173
• InChiKey: SKDWLRPVWTVSKZ-UHFFFAOYSA-N

物化性质

• 沸点：
  230.3±35.0 °C(Predicted)
• 密度：
  1.318±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2903999090

反应信息

• 作为反应物：
  描述：

  2,3,4,6-四氟-1,1'-联苯 生成 2,4,5,6-tetrafluoro-[1,1'-biphenyl]-3-carboxylic acid
  参考文献：
  名称：

  PLUMMER, E. L.

  摘要：

  DOI：
• 作为产物：
  描述：

  溴苯 、 1,2,3,5-四氟苯 在 sodium carbonate 、 溶剂黄146 作用下， 以 N,N-二甲基乙酰胺 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以75%的产率得到2,3,4,6-四氟-1,1'-联苯
  参考文献：
  名称：

  Palladium nanocrystals stabilized by cucurbit[6]uril as efficient heterogeneous catalyst for direct C–H functionalization of polyfluoroarenes

  摘要：

  Palladium nanocrystals (Pd NCs) featuring abundant surface defects are successfully synthesized by using cucurbit[6]uril as a stabilizer. Employing the as-prepared Pd NCs as catalyst, an efficient approach to the direct C-H functionalization of electron-deficient polyfluoroarenes has been developed. The stable Pd NCs catalyst exhibits excellent catalytic activity and good recyclability with significantly low catalyst loading. The catalytic procedure is insensitive to air and moisture and can be manipulated under ambient environment with operational ease. Mechanistic experiments have provided credible data to support a heterogeneous catalytic mechanism of the present system. (C) 2014 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jcat.2014.10.013

文献信息

• Insecticidal [1,1'-biphenyl]-3-ylmethyl esters
  申请人：FMC Corporation

  公开号：US04329518A1

  公开（公告）日：1982-05-11

  [1,1'-Biphenyl]-3-ylmethyl pyrethroid esters, as well as processes, uses, and intermediates thereto, are disclosed. The [1,1'-biphenyl]-3-ylmethyl pyrethroid esters control a broad spectrum of insects as well as acarids.

  [1,1'-联苯]-3-基甲基拟除虫酯酸酯，以及相关的工艺、用途和中间体被披露。这些[1,1'-联苯]-3-基甲基拟除虫酯酸酯可以控制广谱的昆虫和螨虫。
• Insecticidal (1,1'-biphenyl)-3-ylmethyl esters
  申请人：FMC Corporation

  公开号：US04402973A1

  公开（公告）日：1983-09-06

  [1,1'-Biphenyl]-3-ylmethyl pyrethroid esters, as well as processes, uses, and intermediates thereto, are disclosed. The [1,1'-biphenyl]-3-ylmethyl pyrethroid esters control a broad spectrum of insects as well as acarids.

  [1,1'-联苯]-3-基甲基拟除虫酯酸酯，以及相关的工艺、用途和中间体已被披露。[1,1'-联苯]-3-基甲基拟除虫酯酸酯可以控制广泛的昆虫和螨类。
• Palladium-Catalyzed Direct Arylation of Electron-Deficient Polyfluoroarenes with Arylboronic Acids
  作者：Ye Wei、Jian Kan、Min Wang、Weiping Su、Maochun Hong

  DOI：10.1021/ol901200g

  日期：2009.8.6

  The palladium-catalyzed direct arylation of electron-deficient arenes that contain two or more fluorine groups with arylboronic acids was realized. The key to achieving a broad substrate scope with respect to both polyfluorobenzenes and arylboronic acids is the choice of bases depending on acidities of polyfluorobenzenes.

  实现了钯催化的含两个或多个氟基团的缺电子芳烃与芳基硼酸的直接芳基化。就多氟苯和芳基硼酸而言，获得广泛的底物范围的关键是根据多氟苯的酸度选择碱。
• Pd-catalyzed direct arylation of electron-deficient polyfluoroarenes with aryliodine(III) diacetates
  作者：Zhengjiang Fu、Qiheng Xiong、Wenbiao Zhang、Zhaojie Li、Hu Cai

  DOI：10.1016/j.tetlet.2014.11.033

  日期：2015.1

  polyfluoroarenes with readily available aryliodine(III) diacetates was developed with moderate to good yields. The process exhibited good functional tolerance with respect to methyl, methoxy, bromo, chloro, trifluoromethyl, cyano, and aldehyde groups. Mechanistic studies revealed this coupling involved in situ generation of aryl iodide from heating-promoted decomposition of aryliodine(III) diacetate, followed by

  现已开发出Pd催化的缺电子多氟芳烃与易于获得的芳基碘（III）二乙酸酯的直接芳基化反应，产率中等至良好。该方法对于甲基，甲氧基，溴，氯，三氟甲基，氰基和醛基表现出良好的功能耐受性。机理研究表明，这种偶联涉及加热促进的二乙酸芳基碘（III）的分解，原位生成芳基碘化物，然后与多氟芳烃底物偶联，得到所需的产物。
• Insecticidal (1,1'-biphenyl)-3-ylmethyl esters, their production and use and compositions containing them
  申请人：FMC Corporation

  公开号：EP0049977A1

  公开（公告）日：1982-04-21

  Insecticidal and acaricidal pyrethroid esters of formula residue is replaced by a hydroxy group or a leaving group readilv displaced bv carboxylate anions are also novel. in which R is one of certain substituted cyclopropyl radicals, A and B are certain halo, haloalkyl, alkyl and alkoxy radicals and a and b are 0, 1, 2, 3, 4 or 5, are novel and may be included in insecticidal and acaricidal compositions and used for killing insects and acarids. They can be in cis or trans configuration. Intermediate compounds in which the

  杀虫和杀螨剂拟除虫菊酯的式残基被羟基或羧酸阴离子取代的离去基团也是新颖的。 其中 R 是某些取代的环丙基之一，A 和 B 是某些卤代、卤代烷基、烷基和烷氧基，a 和 b 是 0、1、2、3、4 或 5，这些都是新型的，可包含在杀虫和杀螨组合物中，用于杀虫和杀螨。它们可以是顺式或反式构型。 其中