4-methoxyphenyl ethyl carbonate | 22719-84-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-methoxyphenyl ethyl carbonate
• 英文别名: ethyl 4-methoxyphenyl carbonate；carbonic acid ethyl ester-(4-methoxy-phenyl ester)；Hydrochinon-methylaether-O-carbonsaeureaethylester；Kohlensaeure-aethylester-(4-methoxy-phenylester)；Aethyl-(4-methoxy-phenyl)-carbonat；Aethyl-<4-methoxy-phenyl>-carbonat；ethyl (4-methoxyphenyl) carbonate
• CAS: 22719-84-2
• 化学式: C₁₀H₁₂O₄
• 分子量: 196.203
• InChiKey: GBSOFIMKLOZOHN-UHFFFAOYSA-N

物化性质

• 保留指数：
  1505

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methoxyphenyl ethyl carbonate 以 异丙醇 为溶剂， 生成 2-羟基-5-甲氧基苯甲酸乙酯
  参考文献：
  名称：

  Photochemistry of aryl alkyl carbonates. II. Methoxyphenyl ethyl carbonates

  摘要：

  DOI：

  10.1021/jo00985a026
• 作为产物：
  描述：

  对苯二酚 在 sodium hydroxide 、 alkaline solution 作用下， 生成 4-methoxyphenyl ethyl carbonate
  参考文献：
  名称：

  Robinson; Smith, Journal of the Chemical Society, 1926, p. 393

  摘要：

  DOI：

文献信息

• Alkyl and Aryl 4,5-Dichloro-6-oxopyridazin-1(6H)-carboxylates: A Practical Alternative to Chloroformates for the Synthesis of Symmetric and Asymmetric Carbonates
  作者：Yong-Jin Yoon、Hyo Yoon、Hyun Moon、Gi Sung

  DOI：10.1055/s-0035-1561411

  日期：——

  Symmetric and asymmetric carbonates were synthesized by using alkyl or aryl 4,5-dichloro-6-oxopyridazin-1(6 H )-carboxylates. Five aryl 4,5-dichloro-6-oxopyridazin-1(6 H )-carboxylates were converted into the corresponding diaryl carbonates in good to excellent yields by treatment with potassium carbonate in refluxing THF. When the 4,5-dichloro-6-oxopyridazin-1(6 H )-carboxylates were treated with

  通过使用烷基或芳基 4,5-dichloro-6-oxopyridazin-1(6 H)-carboxylates 合成对称和不对称碳酸酯。通过在回流的四氢呋喃中用碳酸钾处理，五种芳基 4,5-二氯-6-氧代哒嗪-1(6 H)-羧酸酯以良好到极好的产率转化为相应的碳酸二芳基酯。当 4,5-二氯-6-氧代哒嗪-1(6 H )-羧酸酯在叔丁醇钾的存在下在甲苯中在室温下用脂肪族或芳香族醇处理时，它们得到相应的对称或不对称碳酸酯。以优异的产量。因此，烷基和芳基 4,5-二氯-6-氧代哒嗪-1(6 H )-羧酸酯是氯甲酸酯的高效、稳定且环保的替代品。
• Synthesis of Organic Carbonates with Alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates and ROH/AlCl₃under Ambient Condition
  作者：Gi Hyeon Sung、Bo Ram Kim、Ki Eun Ryu、Jeum-Jong Kim、Yong-Jin Yoon

  DOI：10.5012/bkcs.2014.35.9.2758

  日期：2014.9.20

  demonstrated the synthesis of organic carbonates using alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)carboxylates and alcohol in the presence of aluminum chloride. Alkyl/aryl 4,5-dichloro-6-oxopyridazine1(6H)-carboxylates were reacted with alcohol in the presence of AlCl3 in toluene at room temperature to afford the corresponding unsymmetric and symmetric organic carbonates in good to excellent yields. These

  我们展示了在氯化铝存在下使用烷基/芳基 4,5-二氯-6-氧代哒嗪-1(6H) 羧酸盐和醇合成有机碳酸酯。烷基/芳基 4,5-二氯-6-氧代哒嗪1(6H)-羧酸盐与醇在 AlCl3 存在下于甲苯中在室温下反应，以良好至优异的收率得到相应的不对称和对称有机碳酸酯。这些都是高效和方便的过程。烷基/芳基 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates 是固体、稳定和无毒的 CO2/CO2R(Ar) 源。值得注意的是，该反应是在环境和酸性条件下进行的，起始原料易于制备和易得，可定量分离出可重复使用的4,5-二氯哒嗪-3(2H)-one。
• DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：US20130079313A1

  公开（公告）日：2013-03-28

  The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

  这项发明涉及磷酸二酯酶4（PDE4）的抑制剂。更具体地，该发明涉及1-苯基-2-吡啶基烷基醇衍生物，制备这类化合物的方法，含有它们的组合物以及它们的治疗用途。
• [EN] DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS<br/>[FR] DÉRIVÉS D'ALCOOLS ALKYLIQUES DE 1-PHÉNYL-2-PYRIDINYLE EN TANT QU'INHIBITEURS DE PHOSPHODIESTÉRASE
  申请人：CHIESI FARMA SPA

  公开号：WO2013045280A1

  公开（公告）日：2013-04-04

  The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

  这项发明涉及磷酸二酯酶4（PDE4）的抑制剂。更具体地，该发明涉及1-苯基-2-吡啶基烷基醇衍生物，制备这类化合物的方法，含有它们的组合物以及它们的治疗用途。
• A New Versatile Synthesis of Esters from Grignard Reagents and Chloroformates
  作者：Angela Punzi、Daniela Bottalico、Vito Fiandanese、Giuseppe Marchese

  DOI：10.1055/s-2007-973861

  日期：2007.4

  Cross-coupling reactions of chloroformates with organocopper reagents, derived from Grignard reagents, cuprous bromide and lithium bromide, provide a rapid and straightforward method for the synthesis of esters.

  氯甲酸酯与衍生自格氏试剂、溴化亚铜和溴化锂的有机铜试剂的交叉偶联反应为酯的合成提供了一种快速而直接的方法。