3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-2-methylpyridin-4(1H)-one | 1219111-72-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-2-methylpyridin-4(1H)-one
• 英文别名: 2-Methyl-3-phenylmethoxy-1-(2-phenylmethoxyethyl)pyridin-4-one
• CAS: 1219111-72-4
• 化学式: C₂₂H₂₃NO₃
• 分子量: 349.43
• InChiKey: RTCFWNJDGNZULC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-2-methylpyridin-4(1H)-one 在 selenium(IV) oxide 、 sodium tetrahydroborate 、 乙酸酐 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 7.0h， 生成 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-2-(hydroxymethyl)pyridine-4(1H)-one
  参考文献：
  名称：

  Novel 3-hydroxypyridin-4-one hexadentate ligand-based polymeric iron chelator: synthesis, characterization and antimicrobial evaluation

  摘要：

  一种新型的基于3-羟基吡啶-4-酮的六齿螯合聚合物铁螯合剂被制备出来。发现该聚合物具有高铁亲和力，并对革兰氏阳性和革兰氏阴性细菌均具有可观的抑制活性。

  DOI：

  10.1039/c5md00264h
• 作为产物：
  描述：

  麦芽醇 在 sodium hydride 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 15.5h， 生成 3-(benzyloxy)-1-(2-(benzyloxy)ethyl)-2-methylpyridin-4(1H)-one
  参考文献：
  名称：

  Novel 3-hydroxypyridin-4-one hexadentate ligand-based polymeric iron chelator: synthesis, characterization and antimicrobial evaluation

  摘要：

  一种新型的基于3-羟基吡啶-4-酮的六齿螯合聚合物铁螯合剂被制备出来。发现该聚合物具有高铁亲和力，并对革兰氏阳性和革兰氏阴性细菌均具有可观的抑制活性。

  DOI：

  10.1039/c5md00264h

文献信息

• PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDONE CARBOXYLIC ACIDS
  申请人：KULANGARA VIJAYA RAJ KUNIYIL

  公开号：US20100076199A1

  公开（公告）日：2010-03-25

  The present invention relates to methods for the preparation of pyridone carboxylic acids for use as intermediates in the preparation of various synthetic organic compounds. The pyridone carboxylic acids can for example be used as intermediates in the production of potent antitumor agents, antifungal agents, antiviral agents, psychotherapeutic agents or contrast imaging agents for MRI.

  本发明涉及用于制备吡啶酮羧酸的方法，用作合成各种有机化合物时的中间体。吡啶酮羧酸可以作为强效抗肿瘤药物、抗真菌药物、抗病毒药物、心理治疗药物或MRI对比成像剂的中间体。
• Design, Synthesis, and Antimicrobial Evaluation of Hexadentate Hydroxypyridinones with High Iron(III) Affinity
  作者：Ming-Xia Zhang、Chun-Feng Zhu、Ying-Jun Zhou、Xiao-Le Kong、Robert C Hider、Tao Zhou

  DOI：10.1111/cbdd.12358

  日期：2014.12

  A range of hexadentate 3‐hydroxypyridin‐4‐ones (HPOs) with high affinity for iron(III) has been synthesized. The log stability constants of two HPO–iron complexes (logK1) were determined to be over 34, and pFe values of the two HPOs were determined to be over 31. Antimicrobial assay indicated that they are able to markedly inhibit the growth of both Gram‐positive and Gram‐negative bacteria. Compounds 14a and 14e were found to exhibit the strongest inhibitory activity against Staphyloccocus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli, with MIC values of 8, 8, 16, and 8 μg/mL, respectively. These results indicate that hexadentate 3‐hydroxypyridin‐4‐ones have potential application as antimicrobial agents, especially in the treatment of wound infection.
• Novel 3-hydroxypyridin-4-one hexadentate ligand-based polymeric iron chelator: synthesis, characterization and antimicrobial evaluation
  作者：Ying-Jun Zhou、Xiao-Le Kong、Jun-Pei Li、Yong-Min Ma、Robert C Hider、Tao Zhou

  DOI：10.1039/c5md00264h

  日期：——

  A novel 3-hydroxypyridin-4-one hexadentate-based copolymeric iron chelator was prepared. The polymer was found to possess high iron affinity and appreciable inhibitory activity against both Gram-positive and Gram-negative bacteria.

  一种新型的基于3-羟基吡啶-4-酮的六齿螯合聚合物铁螯合剂被制备出来。发现该聚合物具有高铁亲和力，并对革兰氏阳性和革兰氏阴性细菌均具有可观的抑制活性。