2-bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one | 1315610-98-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one
• 英文别名: 2-bromo-7-hydroxy-10,11-dihydroindenol[5,4-c]chromen-6(9H)-one；2-Bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9h)-one；2-bromo-7-hydroxy-10,11-dihydro-9H-indeno[5,4-c]chromen-6-one
• CAS: 1315610-98-0
• 化学式: C₁₆H₁₁BrO₃
• 分子量: 331.166
• InChiKey: PDXPNZFYCGCRPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  copper(II) nitrate trihydrate 、 2-bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one 、 ciprofloxacin 在 NaOH 作用下， 以 甲醇 、 水 为溶剂， 以59.5%的产率得到[Cu(H2O)2(2-bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one(-1H))(ciprofloxacin(-1H))]*3H2O
  参考文献：
  名称：

  Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin

  摘要：

  Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. The structure of mixed-ligand complexes was investigated using spectroscopic method, physicochemical and elemental analyses. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.03.032
• 作为产物：
  描述：

  6-bromo-3-coumarinoylmethylpyridinium 、 环戊酮 在 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 以63%的产率得到2-bromo-7-hydroxy-10,11-dihydroindeno[5,4-c]chromen-6(9H)-one
  参考文献：
  名称：

  Antitubercular and fluorescence studies of copper(II) complexes with quinolone family member, ciprofloxacin

  摘要：

  Four new mixed-ligand complexes of Cu(II) with ciprofloxacin (Cip) and uninegative bidentate ligands have been synthesized and characterized. The structure of mixed-ligand complexes was investigated using spectroscopic method, physicochemical and elemental analyses. The fluorescence spectra of complexes show red shift, which may be due to the chelation by the ligands to the metal ion. It enhances ligand ability to accept electrons and decreases the electron transition energy. Antimycobacterial screening of ligand and its copper compound against Mycobacterium tuberculosis shows clear enhancement in the antitubercular activity upon copper complexation. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.03.032

文献信息

• Effect of the Thermal Decomposition and <i>In Vitro</i> Antimicrobial Activity of Mixed Ligand Copper(II) Complexes
  作者：G. J. Kharadi

  DOI：10.1080/15533174.2011.611846

  日期：2012.3.1

  indicate octahedral stereochemistry. TGA and DSC determined thermal stability, order of kinetics, heat capacity, and activation energy of thermal degradation for these complexes. Order of stability of complexes was found to be [Cu(L1)(CQ)(H2O)2].4H2O > [Cu(L2)(CQ)(H2O)2].5H2O > [Cu(L3)(CQ)(H2O)2].3H2O. The ligands, metal salts, complexes, control, and standard drug were tested for their in vitro antibacterial

  作者旨在确定在[Cu（L n）（CQ）（H 2 O）2 ] .xH 2 O（其中L 1 = 2-的类型）的混合配体铜（II）配合物上热分解的活化能。溴7-羟基-10,11-二氢茚并[5,4-c] chromen-6（9H）-one，L 2 = 2-溴-7-羟基-9,10,11,12-四氢-6H- naphtho [2,1-c] chromen-6-one，L 3 = 5-bromo-14-hydroxy-7,8-dihydro-1H-phenanthro [2,1-c] chromen-1-one，x = 4，5，3）在室温下进行研究。所有化合物均已通过元素分析，磁化率，FT-IR，1 H-NMR，13表征C-NMR，电子光谱和FAB-质谱。电子光谱和磁化率测量表明八面体立体化学。TGA和DSC确定了这些配合物的热稳定性，动力学顺序，热容量和热降解活化能。发现络合物的稳定性顺序为[Cu（L