4-((4-methoxybenzyloxy)methyl)benzaldehyde | 1333080-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-((4-methoxybenzyloxy)methyl)benzaldehyde
• 英文别名: 4-[(4-Methoxyphenyl)methoxymethyl]benzaldehyde
• CAS: 1333080-48-0
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: DWQRFPYLULOKKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-((4-methoxybenzyloxy)methyl)benzaldehyde 在 草酰氯 、 dimethyl sulfide borane 、 potassium tert-butylate 、 二甲基亚砜 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 9.0h， 生成 2-(4-((4-methoxybenzyloxy)methyl)phenyl)propan-1-ol
  参考文献：
  名称：

  Asymmetric synthesis of the active form of loxoprofen and its analogue

  摘要：

  The asymmetric synthesis of the active form of the antiinflammatory drug loxoprofen has been reported in this article. Enzymatic kinetic resolution/racemization of a substituted homo-benzylic primary alcohol with lipase-PS, asymmetric alkylation of cyclic ketones using either Enders' or Meyers' strategy followed by a stereoselective biocatalytic reduction of carbonyl group are the key reactions employed successfully to achieve the target molecule and one of its analogue. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.06.019
• 作为产物：
  描述：

  对苯二甲醇 在 草酰氯 、 sodium hydride 、 二甲基亚砜 作用下， 以 四氢呋喃 、 二氯甲烷 、 mineral oil 为溶剂， 反应 3.75h， 生成 4-((4-methoxybenzyloxy)methyl)benzaldehyde
  参考文献：
  名称：

  Asymmetric synthesis of the active form of loxoprofen and its analogue

  摘要：

  The asymmetric synthesis of the active form of the antiinflammatory drug loxoprofen has been reported in this article. Enzymatic kinetic resolution/racemization of a substituted homo-benzylic primary alcohol with lipase-PS, asymmetric alkylation of cyclic ketones using either Enders' or Meyers' strategy followed by a stereoselective biocatalytic reduction of carbonyl group are the key reactions employed successfully to achieve the target molecule and one of its analogue. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.06.019

文献信息

• [EN] PEPTIDE DRUG CONJUGATES<br/>[FR] CONJUGUÉS PEPTIDES-MÉDICAMENTS
  申请人：EISAI R&D MAN CO LTD

  公开号：WO2017136769A1

  公开（公告）日：2017-08-10

  Embodiments provide protein-drug conjugates for treatment of cancer. Protein-drug conjugates may include protein-drug conjugates of Formula I: Ctx-L-Cp (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: Ctx is chlorotoxin or a chlorotoxin analog; Cp is a cryptophycin amide, and L is a linker wherein the linker is bound to Ctx at an X2 moiety of the linker and at one of a lysine residue and the N-terminus of the chlorotoxin or chlorotoxin analog.
• Asymmetric synthesis of the active form of loxoprofen and its analogue
  作者：Rajib Bhuniya、Samik Nanda

  DOI：10.1016/j.tetasy.2011.06.019

  日期：2011.5

  The asymmetric synthesis of the active form of the antiinflammatory drug loxoprofen has been reported in this article. Enzymatic kinetic resolution/racemization of a substituted homo-benzylic primary alcohol with lipase-PS, asymmetric alkylation of cyclic ketones using either Enders' or Meyers' strategy followed by a stereoselective biocatalytic reduction of carbonyl group are the key reactions employed successfully to achieve the target molecule and one of its analogue. (C) 2011 Elsevier Ltd. All rights reserved.