methyl 6-bromo-1H-benzo[d]imidazole-4-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 6-bromo-1H-benzo[d]imidazole-4-carboxylate
• 英文别名: Methyl 5-bromo-1H-benzo[d]imidazole-7-carboxylate；methyl 6-bromo-1H-benzimidazole-4-carboxylate
• 化学式: C₉H₇BrN₂O₂
• 分子量: 255.071
• InChiKey: DHWXTUDTTDQFJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 6-bromo-1H-benzo[d]imidazole-4-carboxylate 在 N-甲基吗啉 、 锂硼氢 、 甲基磺酰氯 、 N,N-二异丙基乙胺 、 lithium chloride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 15.0h， 生成 6-Bromo-4-(chloromethyl)-1-tritylbenzimidazole
  参考文献：
  名称：

  NRF2-ACTIVATING COMPOUND

  摘要：

  A compound having Nrf2-activating action is provided. The compound is represented by formula (I), a salt of the compound, or a solvate of the compound or salt: wherein R 1a and R 1b are identical or different and represent a hydrogen atom, an alkyl group, or a halogen atom; R 2 represents an optionally substituted group derived from a heterocycle, and the heterocycle represents thiophene, furan, pyrrole, thiazole, or a fused ring including any of these heterocycles; R 4 and R 5 are identical or different and represent a hydrogen atom or an optionally substituted alkyl group, or R 4 and R 5 bind with each other to form —NH—CH—N—; R 6 represents an optionally substituted alkyl group; A 1 , A 2 , A 3 , and A 4 are identical or different and represent CH or N wherein the number of N is 1 or less; and Z represents a hydrogen atom or a halogen atom.

  公开号：

  US20230024995A1
• 作为产物：
  描述：

  2-氨基-5-溴-3-硝基硼酸甲酯 在 tin(ll) chloride 作用下， 以 甲醇 为溶剂， 反应 2.5h， 生成 methyl 6-bromo-1H-benzo[d]imidazole-4-carboxylate
  参考文献：
  名称：

  NRF2-ACTIVATING COMPOUND

  摘要：

  A compound having Nrf2-activating action is provided. The compound is represented by formula (I), a salt of the compound, or a solvate of the compound or salt: wherein R 1a and R 1b are identical or different and represent a hydrogen atom, an alkyl group, or a halogen atom; R 2 represents an optionally substituted group derived from a heterocycle, and the heterocycle represents thiophene, furan, pyrrole, thiazole, or a fused ring including any of these heterocycles; R 4 and R 5 are identical or different and represent a hydrogen atom or an optionally substituted alkyl group, or R 4 and R 5 bind with each other to form —NH—CH—N—; R 6 represents an optionally substituted alkyl group; A 1 , A 2 , A 3 , and A 4 are identical or different and represent CH or N wherein the number of N is 1 or less; and Z represents a hydrogen atom or a halogen atom.

  公开号：

  US20230024995A1

文献信息

• HETEROBICYCLIC AMIDES AS INHIBITORS OF CD38
  申请人：Ribon Therapeutics, Inc.

  公开号：US20210032251A1

  公开（公告）日：2021-02-04

  The present invention relates to heterobicyclic amides and related compounds which are inhibitors of CD38 and are useful in the treatment of cancer.

  本发明涉及杂环酰胺及相关化合物，它们是CD38的抑制剂，可用于治疗癌症。
• [EN] BENZIMIDAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2021209484A1

  公开（公告）日：2021-10-21

  The invention relates to a compound of formula (I) wherein R1-R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

  本发明涉及一种式为（I）的化合物，其中R1-R4如说明书和权利要求中所定义。该式（I）的化合物可用作药物。
• [EN] SUBSTITUTED HETEROCYCLIC AMIDE COMPOUND AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF<br/>[FR] COMPOSÉ AMIDE HÉTÉROCYCLIQUE SUBSTITUÉ AINSI QUE SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION PHARMACEUTIQUE<br/>[ZH] 取代的杂环酰胺类化合物，其制法与医药上的用途
  申请人：GENFLEET THERAPEUTICS SHANGHAI INC

  公开号：WO2020192562A1

  公开（公告）日：2020-10-01

  一种对RIPK1具有选择抑制作用的取代的杂环酰胺类化合物及其药学上可接受的盐、立体异构体、溶剂化合物或前药，包含该化合物的药物组合物，及其在制备治疗RIPK1相关疾病或病症药物中的应用。
• Nrf2 활성화 화합물
  申请人：센주 세이야꾸 가부시키가이샤

  公开号：KR20230127268A

  公开（公告）日：2023-08-31

  Nrf2 활성화 작용을 갖는 화합물을 제공하는 것. 일반식 (I)로 표시되는 화합물, 혹은 일반식 (II)의 식 중 *로 나타내지는 탄소 원자를 비대칭 탄소 원자로 하는 2군의 디아스테레오머 중, 극성이 낮은 쪽의 군의 화합물, 그들의 염, 및 그들의 용매화물.

  提供具有Nrf2活化作用的化合物。一种一般式(I)表示的化合物，或者一般式(II)的式中用*表示的碳原子作为非对映碳原子的两类中极性较低的类别的化合物，它们的盐，以及它们的溶剂化物。
• EP3943488
  申请人：——

  公开号：——

  公开（公告）日：——