9,10-epoxy-18-hydroxyoctadecanoic acid, sodium salt

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9,10-epoxy-18-hydroxyoctadecanoic acid, sodium salt
• 英文别名: Sodium;8-[3-(8-hydroxyoctyl)oxiran-2-yl]octanoate；sodium;8-[3-(8-hydroxyoctyl)oxiran-2-yl]octanoate
• 化学式: C₁₈H₃₃O₄*Na
• 分子量: 336.447
• InChiKey: NTQGDDFSTATPCB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.04
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  72.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  18-hydroxyoctadec-9-enoic acid, sodium salt 、 9,10-epoxy-18-hydroxyoctadecanoic acid, sodium salt 、 threo-9,10,18-trihydroxyoctadecanoic acid, sodium salt 、 22-hydroxydocosanoic acid, sodium salt 、 sodium betulinate 在 盐酸 作用下， 以 水 为溶剂， 生成 白桦脂酸 、 9,10-epoxy-18-hydroxy-octadecanoic acid 、 18-hydroxyoctadec-9-enoic acid 、 Phloionol-saeure 、 22-羟基二十二烷酸
  参考文献：
  名称：

  WO2007/121482

  摘要：

  公开号：

文献信息

• Anti-fungal formulation of triterpene and essential oil
  申请人：Carlson M. Robert

  公开号：US20050014730A1

  公开（公告）日：2005-01-20

  The present invention provides for pharmaceutical compositions that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides for a cosmetic formulation that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides a method of treating a fungal infection that includes administering (e.g., topically applying) an effective amount of the pharmaceutical composition to the tissue afflicted with the fungal infection, or the tissue at risk of being afflicted with the fungal infection.

  本发明提供的药物组合物包括一种三萜（如白桦脂）和一种精油（Vicks® Vapor Rub）。本发明还提供了一种化妆品配方，其中包括一种三萜（如白桦脂素）和一种精油（Vicks® Vapor Rub）。本发明还提供了一种治疗真菌感染的方法，该方法包括将有效量的药物组合物施用于（如局部施用）受真菌感染的组织或有受真菌感染风险的组织。
• Compositions that include a triterpene and a carrier
  申请人：Krasutsky A. Pavel

  公开号：US20060003948A1

  公开（公告）日：2006-01-05

  The present invention provides for compositions that includes a triterpene (e.g., betulin) and a carrier (e.g., lanolin). The compositions are useful for skin care (e.g., as cosmetic formulations), and as therapeutic formulations, e.g., for treating topical fungal infections.

  本发明提供了包括三萜（如白桦脂）和载体（如羊毛脂）的组合物。这些组合物可用于皮肤护理（如化妆品配方）和治疗配方，如治疗局部真菌感染。
• [EN] ANTI-FUNGAL FORMULATION OF TRITERPENE AND ESSENTIAL OIL<br/>[FR] PREPARATION ANTIFONGIQUE A BASE DE TRITERPENE ET D'HUILE ESSENTIELLE
  申请人：UNIV MINNESOTA

  公开号：WO2004089357A2

  公开（公告）日：2004-10-21

  The present invention provides for pharmaceutical compositions that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides for a cosmetic formulation that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides a method of treating a fungal infection that includes administering (e.g., topically applying) an effective amount of the pharmaceutical composition to the tissue afflicted with the fungal infection, or the tissue at risk of being afflicted with the fungal infection.
• [EN] COMPOSITIONS THAT INCLUDE A TRITERPENE AND A CARRIER<br/>[FR] COMPOSITIONS COMPRENANT UN TRITERPENE ET UN EXCIPIENT
  申请人：UNIV MINNESOTA

  公开号：WO2005077377A1

  公开（公告）日：2005-08-25

  The present invention provides for compositions that includes a triterpene (e.g., betulin) and a carrier (e.g., lanolin). The compositions are useful for skin care (e.g., as cosmetic formulations), and as therapeutic formulations, e.g., for treating topical fungal infections.
• WO2007/121482
  申请人：——

  公开号：——

  公开（公告）日：——