sodium N^α-lauramide lysine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: sodium N^α-lauramide lysine
• 英文别名: N-Lauroyl-DL-lysinesodiumsalt；sodium;(2S)-6-amino-2-(dodecanoylamino)hexanoate
• 化学式: C₁₈H₃₅N₂O₃*Na
• 分子量: 350.477
• InChiKey: HYXYVOOPTRUMSN-NTISSMGPSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.72
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L-赖氨酸 在 水 、 sodium carbonate 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 、 正己醇 为溶剂， 反应 8.0h， 生成 sodium N^α-lauramide lysine
  参考文献：
  名称：

  Nα-酰化赖氨酸衍生物的设计、合成和性能研究†

  摘要：

  氨基酸类化合物作为环境友好的生物基材料引起了人们的关注。我们小组最近开发了一个新的基于N α -酰化赖氨酸的衍生物家族。我们通过避免氨基保护和脱保护过程的新合成路线选择性地在N α位置引入长链酰基。N α -辛酰胺赖氨酸钠(C8)、N α -己酰胺赖氨酸钠 (C10) 和N α钠-月桂酰胺赖氨酸（C12）可以自发自组装成囊泡。因此，它们不仅在药物传递系统方面具有潜力，而且可以作为生物基表面活性剂应用于化妆品和其他行业。

  DOI：

  10.1039/c9ra00213h

文献信息

• Aqueous solution containing bis(N epsilon lauroyllysine)dicarboxylic acid diamide and/or salt thereof, and method for producing same
  申请人：AJINOMOTO CO., INC.

  公开号：US10202333B2

  公开（公告）日：2019-02-12

  The present invention provides a method of producing an aqueous solution containing bis(Nε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, and having a pH of 9-11, which includes a first step of reacting Nε-lauroyl lysine and/or a salt thereof with dicarboxylic acid dichloride in a water solvent having a pH of 12-14 to form bis(Nε-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, a second step of adjusting the aqueous solution obtained in the first step to pH 7.5-8.5, a third step of adding Nε-lauroyl lysine to the aqueous solution obtained in the second step and filtering the mixture, and a fourth step of adjusting the aqueous solution obtained in the third step to pH 9-11.

  本发明提供了一种生产含有双(Nε-月桂酰赖氨酸)二羧酸二酰胺和/或其盐的水溶液且 pH 值为 9-11 的方法、其中包括第一步将 Nε-月桂酰赖氨酸和/或其盐与二羧酸二氯化物在 pH 值为 12-14 的水溶剂中反应生成双(Nε-月桂酰赖氨酸)二羧酸二酰胺和/或其盐，第二步将第一步得到的水溶液调节至 pH 值为 7.5-8.5，第三步将Nε-月桂酰赖氨酸加入到第二步得到的水溶液中并过滤混合物，第四步将第三步得到的水溶液调节到pH 9-11。
• EP3205641A1
  申请人：——

  公开号：EP3205641A1

  公开（公告）日：2017-08-16
• Fatty Acid Acylated Amino Acids for Growth Hormone Delivery
  申请人：Novo Nordisk Health Care AG

  公开号：US20150250882A1

  公开（公告）日：2015-09-10

  The present invention relates to growth hormone compositions comprising a fatty acid acylated amino acids (FA-aa's), which may be used in pharmaceutical compositions such as pharmaceutical compositions for oral administration of growth hormone.
• AQUEOUS SOLUTION CONTAINING BIS(N EPSILON LAUROYLLYSINE)DICARBOXYLIC ACID DIAMIDE AND/OR SALT THEREOF, AND METHOD FOR PRODUCING SAME
  申请人：AJINOMOTO CO., INC.

  公开号：US20170260127A1

  公开（公告）日：2017-09-14

  The present invention provides a method of producing an aqueous solution containing bis(N ε -lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, and having a pH of 9-11, which includes a first step of reacting N ε -lauroyl lysine and/or a salt thereof with dicarboxylic acid dichloride in a water solvent having a pH of 12-14 to form bis(N ε -lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, a second step of adjusting the aqueous solution obtained in the first step to pH 7.5-8.5, a third step of adding N ε -lauroyl lysine to the aqueous solution obtained in the second step and filtering the mixture, and a fourth step of adjusting the aqueous solution obtained in the third step to pH 9-11.
• [EN] COMPACT POWDER FREE OF BINDER IN FREE FORM<br/>[FR] POUDRE COMPACTE EXEMPTE DE LIANT SOUS FORME LIBRE
  申请人：OREAL

  公开号：WO2010061242A1

  公开（公告）日：2010-06-03

  The present invention relates to a cosmetic composition in the form of a compact powder for making up and/or caring for the skin, comprising less than 5% by weight, preferably less than 3% by weight of binder in a free form relative to the total weight of the composition and at least one surface treated powder in an amount of at least 35% by weight relative to the total weight of the composition, said powder being a filler and/or a pigment, wherein said at least one surface treated powder is coated with a fat ester oil. The present invention further relates to a cosmetic process for making up and/or caring for the skin comprising at least one step of applying to the skin at least one composition according to the present invention.