<(4-biphenylyl)methyl>triphenylphosphonium chloride | 114854-76-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <(4-biphenylyl)methyl>triphenylphosphonium chloride
• 英文别名: ([1,1'-biphenyl]-4-ylmethyl)triphenylphosphonium chloride；Biphenylmethylenetriphenylphosphonium chloride；Triphenyl-[(4-phenylphenyl)methyl]phosphanium;chloride
• CAS: 114854-76-1
• 化学式: C₃₁H₂₆P*Cl
• 分子量: 464.974
• InChiKey: ARIZCIJOEMTYBC-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.85
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  <(4-biphenylyl)methyl>triphenylphosphonium chloride 在 potassium tert-butylate 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.5h， 生成 (2S,3R)-2,3-di([1,1'-biphenyl]-4-yl)oxirane
  参考文献：
  名称：

  y光氧化还原催化剂的重新设计及其在羰基叶立德化学反应中的应用

  摘要：

  我们报告探索photoredox代从苄环氧化物羰基叶立德采用全新设计的4-三甲-2,6- diphenylpyrylium四氟硼酸盐（MDPT）和4-三甲-2,6-二p -tolylpyrylium四氟硼酸盐（MD（p甲苯基）PT）催化剂。这些催化剂在可见光波长下被激发，具有很高的鲁棒性，并且表现出某些报道的最高氧化电位。在从苄基环氧化物温和而有效地生成羰基化物中证明了它们的效用，否则当前的普通光氧化还原催化剂无法实现。

  DOI：

  10.1021/acs.orglett.7b01222

文献信息

• Synthesis and Activity of a Novel Series of 3-Biarylquinuclidine Squalene Synthase Inhibitors
  作者：George R. Brown、David S. Clarke、Alan J. Foubister、Susan Freeman、Peter J. Harrison、Michael C. Johnson、Keith B. Mallion、John McCormick、Fergus McTaggart、Alan C. Reid、Graham J. Smith、Melvyn J. Taylor

  DOI：10.1021/jm950907l

  日期：1996.1.1

  Quinuclidines with a 3-biaryl substituent are a new class of potent, orally active squalene synthase (SQS) inhibitors. Variants around these rigid structures indicate key structural requirements for cationic SQS inhibitors. Thus the lower in vitro potency found for quinuclidines bearing 3-substituents, which did not overlay the biphenyl group of 3-(biphenyl-4-yl)-3-hydroxyquinuclidine (2) (IC50 = 16

  具有3-联芳基取代基的喹核苷是一类新的有效的，口服活性的角鲨烯合酶（SQS）抑制剂。这些刚性结构周围的变化指示出阳离子SQS抑制剂的关键结构要求。因此，暗示了带有3个取代基的喹核苷的体外效价较低，该奎尼啶没有覆盖3-（联苯基-4-基）-3-羟基喹核苷（2）的联苯基团（IC50 = 16 nM，大鼠微粒体SQS）。 3取代基的方向性要求。类似地，3-三联苯类似物6的较低效能（IC50 = 370 nM）表明该取代基的尺寸受到限制。在具有奎宁环和联苯环之间连接基团的化合物中，亲脂性较低的连接基团的耐受性较差（例如，17，CH2CH2，IC50 = 5 nM与19，NHCO，IC50 = 1.2 microM）。用更具极性的吡啶杂环取代2的远端苯环会导致体外效能降低。通常，大鼠体内的良好体内活性仅限于3-羟基类似物，其中3- [4-（吡啶-4-基）苯基]衍生物39（IC50 = 161 nM）显示出最佳的抑制作用（口服给药后）
• AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0882699A1

  公开（公告）日：1998-12-09

  The present invention provides an amino compound represented by Formula: wherein X is CH2NH or CONH, Y is CH2NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R4)R5, CH2CH(R4)R5 or an alkoxycarbonyl group, R1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R2 and R3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R4 and R5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.

  本发明提供了一种由式表示的氨基化合物： 其中X是CH2NH或CONH，Y是CH2NH或CONH，但X和Y不能同时是CONH；Z是CH=C(R4)R5，CH2CH(R4)R5或烷氧基羰基，R1是氢原子；一个低级烷基、一个环烷基、一个环烷基取代的烷基、一个芳烷基或一个芳基，其中每个基团都是取代或未取代的，R2 和 R3 各自独立地是一个低级烷基或一个芳烷基，其中每个基团都是取代或未取代的，R4 和 R5 各自独立地是一个氢原子；烷基、芳烷基、芳基或杂芳基，其中每个基团被取代或未被取代，或其药学上可接受的盐； 包含式（1）的氨基化合物或其药学上可接受的盐的药物；和一种血管紧张素 IV 受体激动剂，其中含有作为有效成分的血管紧张素 IV 受体激动剂，它们尤其可作为治疗药物（拮抗剂或激动剂），用于治疗血管紧张素 IV 参与的各种疾病，例如加速肾血流、扩张脑血管、抑制细胞增殖和记忆力减退。
• A search for photoresolvable mesogens: synthesis and properties of a series of liquid crystalline, axially chiral 1-benzylidene-4-[4'-[(p-alkylphenyl)ethynyl]phenyl]cyclohexanes
  作者：Yifan Zhang、Gary B. Schuster

  DOI：10.1021/jo00086a042

  日期：1994.4

  A series of axially chiral 1-benzylidene-4-[4'-[(p-alkylphenyl)ethynyl] phenyl]cyclohexanes was prepared in racemic form and as optically active mixtures by application of the Hanessian olefination reaction. These compounds have two spectrally overlapping groups which leads to enhanced circular dichroism. And, with appropriate substituents, they form liquid crystal phases when heated above room temperature. The photochemical and material properties of these compounds were studied to assess their suitability for formation of a chiroptical liquid crystal switch. It was found that the Kuhn anisotropy factor (g(lambda)) is too small for this application.
• Listvan, V. N.; Stasyuk, A. P.; Kornilov, M. Yu., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 11.2, p. 2168 - 2171
  作者：Listvan, V. N.、Stasyuk, A. P.、Kornilov, M. Yu.、Komarov, I. V.

  DOI：——

  日期：——
• Bicyclische Peroxide
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0311955B1

  公开（公告）日：1993-04-21