| 36400-86-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 36400-86-9
• 化学式: C₁₆H₃₂O₁₀S₂
• 分子量: 448.556
• InChiKey: KWEAENDJBSIFAP-ICPDPVJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.92
• 重原子数：
  28.0
• 可旋转键数：
  12.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  180.3
• 氢给体数：
  8.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  在 吡啶 、 高碘酸 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 20.0h， 生成 octa-O-acetyl D-lactose
  参考文献：
  名称：

  Synthesis of peracetylated C-1-deoxyalditol- and C-glycoside-dipyrranes via dithioacetal derivatives

  摘要：

  Dipyrranes bearing peracetylated mono- or disaccharidic C-1-deoxyalditol moieties were prepared from D-galactose, c-glucose, c-mannose, and lactose. A partially hydrolyzed polysaccharide (agarose) was also used as starting material for the synthesis of a disaccharide-containing C-glycoside dipyrrane. These compounds were synthesized as follows: the sugar starting materials were first submitted to a mercaptolysis-acetylation one-pot procedure (EtSH/HCl-Ac2O/pyridine). The resulting peracetylated diethyl dithioacetals were converted into dipyrranes through carbonyl deprotection (H5IO6, THF-Et2O) followed by TFA-catalyzed pyrrole condensation with yields up to 62%. Overall yields from sugar starting materials were up to 49%. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.12.048
• 作为产物：
  描述：

  Lactose 、 乙硫醇 在 盐酸 作用下， 以 水 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Synthesis of peracetylated C-1-deoxyalditol- and C-glycoside-dipyrranes via dithioacetal derivatives

  摘要：

  Dipyrranes bearing peracetylated mono- or disaccharidic C-1-deoxyalditol moieties were prepared from D-galactose, c-glucose, c-mannose, and lactose. A partially hydrolyzed polysaccharide (agarose) was also used as starting material for the synthesis of a disaccharide-containing C-glycoside dipyrrane. These compounds were synthesized as follows: the sugar starting materials were first submitted to a mercaptolysis-acetylation one-pot procedure (EtSH/HCl-Ac2O/pyridine). The resulting peracetylated diethyl dithioacetals were converted into dipyrranes through carbonyl deprotection (H5IO6, THF-Et2O) followed by TFA-catalyzed pyrrole condensation with yields up to 62%. Overall yields from sugar starting materials were up to 49%. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2012.12.048