3-羟基-3,4,4-三甲基-戊酸 | 16466-40-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3-羟基-3,4,4-三甲基-戊酸
• 英文名称: 3-hydroxy-3,4,4-trimethyl-valeric acid
• 英文别名: 3-Hydroxy-3,4,4-trimethyl-valeriansaeure；3-Hydroxy-2.2.3-trimethyl-pentansaeure-(5)；2-Oxy-2.3.3-trimethyl-butan-carbonsaeure-(1)；β-Oxy-tert.-butyl-buttersaeure；β-Oxy-β.γ.γ-trimethyl-butan-α-carbonsaeure；β-Oxy-β.γ.γ-trimethyl-n-valeriansaeure；3-Hydroxy-3,4,4-trimethylpentanoic acid
• CAS: 16466-40-3
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: RTKITZIRJNYAPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2918199090

反应信息

• 作为反应物：
  描述：

  3-羟基-3,4,4-三甲基-戊酸 在 乙酸酐 作用下， 生成 3-tert.-Butyl-crotonsaeure
  参考文献：
  名称：

  THE DEHYDRATION OF 3-HYDROXY-3,4,4-TRIMETHYLPENTANOIC ACID¹

  摘要：

  DOI：

  10.1021/jo01185a003
• 作为产物：
  描述：

  Ethyl 3-hydroxy-3,4,4-trimethylpentanoate 生成 3-羟基-3,4,4-三甲基-戊酸
  参考文献：
  名称：

  Sung, Annales de Chimie (Cachan, France), 1924, vol. <10>1, p. 364

  摘要：

  DOI：

文献信息

• Stereoselective Syntheses of α-Substituted Cyclic Ethers and<i>syn</i>-1,3-Diols
  作者：Koichi Homma、Haruhiro Takenoshita、Teruaki Mukaiyama

  DOI：10.1246/bcsj.63.1898

  日期：1990.7

  system of antimony pentachloride, chlorotrimethylsilane and tin(II) iodide, α-substituted cyclic ethers are stereoselectively prepared from lactones by successive treatment with 1-(t-butyldimethylsiloxy)-1-ethoxyethene and silyl nucleophiles such as triethylsilane, allyltrimethylsilane and trimethylsilyl cyanide. These catalysts also promote the reaction of γ-, δ-, and e-trimethylsiloxy carbonyl compounds

  在催化量的三苯基甲基六氯锑酸盐或五氯化锑、氯三甲基硅烷和碘化锡(II)的催化体系存在下，通过1-(叔丁基二甲基甲硅烷氧基)-1-连续处理，由内酯立体选择性地制备α-取代环醚乙氧基乙烯和甲硅烷基亲核试剂，例如三乙基硅烷、烯丙基三甲基硅烷和三甲基硅烷基氰化物。这些催化剂还促进 γ-、δ-和 e-三甲基甲硅烷氧基羰基化合物与甲硅烷基亲核试剂的反应，从而形成 α-取代的环醚。前一种程序有效地应用于 (-)-顺式玫瑰氧化物和 (cis-6-methyltetrahydro-2-pyranyl) 乙酸（一种麝猫香的成分）的短程合成。此外，syn-1,3-二醇也由内酯类似物立体选择性地制备，
• Selenium Regulates Expression in Rat Liver of Genes for Proteins Involved in Iron Metabolism
  作者：Merrill J. Christensen、Cari A. Olsen、David V. Hansen、Blake C. Ballif

  DOI：10.1385/bter:74:1:55

  日期：——

  Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Se-deficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in Se adequacy and deficiency. Weanling male Sprague-Dawley rats were fed Torula yeast diets supplemented with 0 or 0.15 mu g Se/kg diet as sodium selenite for 15 wk. Activity of cellular glutathione peroxidase was virtually abolished in Se-deficient rat liver, whereas activity of glutathione S-transferase was 43% higher than in Se-adequate liver. There were no differences in hematocrit, hemoglobin, or liver iron content. To examine differential gene expression, we used a multiplex relative reverse transcriptase-polymerase chain reaction method. Three of the six genes examined showed modest but consistent upregulation in Se deficiency. Transferrin mRNA was 30% more abundant in Se-deficient than in Se-adequate liver. For the transferrin receptor, the difference was 32%, and for iron regulatory protein 1, it was 63%. No consistent differences were observed for iron regulatory protein 2 or for ferritin light or heavy chain. These findings suggest a possible role for dietary Se in moderating iron metabolism.
• Metzger,C. et al., Chemische Berichte, 1967, vol. 100, p. 1817 - 1823
  作者：Metzger,C. et al.

  DOI：——

  日期：——
• Dubois; Maroni-Barnaud, Bulletin de la Societe Chimique de France, 1953, p. 946,948
  作者：Dubois、Maroni-Barnaud

  DOI：——

  日期：——
• Gnedin, Journal fur praktische Chemie (Leipzig 1954), 1898, vol. <2> 57, p. 107 - 110
  作者：Gnedin

  DOI：——

  日期：——